Abstract
The microstructure and properties of amorphous D,L-polylactide subjected to different treatments in supercritical carbon dioxide (SC-CO2) were investigated. Atomic force microscopy analysis demonstrated that plasticization and subsequent foaming of the polymer in SC-CO2 leads to significant changes in its internal structure, which are caused by the rearrangement of the supramolecular structure of polylactic acid. The formation of micro and meso pores and an accompanying increase of polylactide void volume are directly related to the destruction of polymer initial intermolecular bonds during the release of SC-CO2. These changes facilitate the formation of thermodynamically more stable conformations, which is manifested in a significant (1.7–5.0-fold) increase of the values of exothermic effects registered by differential scanning calorimetry in the temperature range from −30 to −10°C and near 30–40°C.
Similar content being viewed by others
References
Biocompatible Materials, Ed. by V. I. Sevast’yanov and M. P. Kirpichnikov (MIA, Moscow, 2011) [in Russian].
M. I. Shtil’man, Polymers of Medical-Biological Purposes (Akademkniga, Moscow, 2006) [in Russian].
C. Wischke and S. P. Schwendeman, Int. J. Pharmaceut. 364, 298 (2008).
J. Jagur-Grodzinski, Polym. Adv. Technol. 17, 395 (2006).
Y. Xu, Q. Pei Liub, A. El Ghzaouia, and S. Lia, Int. J. Pharmaceut. 394, 43 (2010).
H. Yoshizawa, S. Hishino, K. Shiomori, S. Natsugoe, T. Aiko, and Y. Kitamura, Int. J. Pharmaceut. 296, 112 (2005).
H. Tai, V. K. Popov, K. M. Shakesheff, and S. M. Howdle, Biochem. Soc. Trans. 35, 516 (2007).
R. Pini, G. Storti, M. Mazzotti, H. Tai, K. M. Shakesheff, and S. M. Howdle, Macromol. Symp. 259, 197 (2007).
H. Tai, C. E. Upton, L. J. White, R. Pini, G. Storti, M. Mazzotti, K. M. Shakesheff, and S. M. Howdle, Polymer 51, 1425 (2010).
P. H. S. Picciani, E. S. Medeiros, L. H. C. Mattoso, L. H. Capparelli, and B. G. Soares, LNLS Activity Report (Brazilian Synchrotron Light Laboratory, 2009).
Q. X. Hou, X. S. Chai, R. Yang, T. Elder, and A. J. Ragauskas, J. Appl. Polym. Sci. 99, 1346 (2006).
V. K. Popov, A. P. Krasnov, A. I. Volozhin, and S. M. Howdle, Perspekt. Mater., No. 4, 49 (2004).
V. N. Bagratashvili, S. E. Bogorodskii, A. N. Konovalov, A. P. Kubyshkin, A. A. Novitskii, V. K. Popov, K. Upton, and S. M. Howdle, Sverkhkrit. Fluidy Teor. Prakt. 2(1), 53 (2007).
Q. Zhong, D. Inniss, K. Kjoller, and V. B. Elings, Surf. Sci. Lett. 290, 688 (1993).
S. N. Magonov, V. Elings, and M.-H. Whangbo, Surf. Sci. Lett. 375, 385 (1997).
D. Qin and R. T. Kean, Appl. Spectrosc. 52, 488 (1998).
J. J. A. Barry, M. M. C. G. Silva, V. K. Popov, K. M. Shakeheff, and S. M. Howdle, Philos. Trans. R. Soc. A 364, 249 (2006).
W. Zhai, Y. Ko, W. Zhu, A. Wong, and C. B. Park, Int. J. Mol. Sci. 10, 5381 (2009).
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © S.E. Bogorodskii, T.S. Zarkhina, E.V. Kuznetsov, S.A. Minaeva, V.K. Popov, A.B. Solov’eva, P.S. Timashev, 2013, published in Sverkhkriticheskie Flyuidy: Teoriya i Praktika, 2013, Vol. 8, No. 2, pp. 84–93.
Rights and permissions
About this article
Cite this article
Bogorodskii, S.E., Zarkhina, T.S., Kuznetsov, E.V. et al. Morphological changes of the polylactic acid microstructure under the action of supercritical carbon dioxide. Russ. J. Phys. Chem. B 8, 924–931 (2014). https://doi.org/10.1134/S1990793114070057
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1990793114070057