Abstract
SEVERAL peptidases which are active around neutral pH have been described in polymorphonuclear (PMN) leucocytes. One of these, which we have found concentrated within the lysosomes of rabbit peritoneal exudate PMN cells, hydrolyses histone but not haemoglobin at neutral pH1,2. Here we compare the subcellular distribution of this enzyme with that of three peptidases active at near-neutral pH in rabbit PMN cells. Hydrolysis of their respective substrates seems to be due to separate activities, and this distinction must precede any attempts to ascribe a function to the enzymes in tissue injury3–6.
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DAVIES, P., KRAKAUER, K. & WEISSMANN, G. Subcellular Distribution of Neutral Protease and Peptidases in Rabbit Polymorphonuclear Leucocytes. Nature 228, 761–762 (1970). https://doi.org/10.1038/228761a0
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DOI: https://doi.org/10.1038/228761a0
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