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Reduce the risk of adverse events associated with disease-modifying therapies for multiple sclerosis by following appropriate mitigation strategies

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Abstract

A number of disease-modifying therapy options are available to treat multiple sclerosis. Careful consideration of the benefits and risks of each agent, as well as the preferences and characteristics of the individual patient, is needed when selecting the most appropriate treatment approach for each patient. Risk migration strategies should be followed to reduce the likelihood and severity of potential adverse effects.

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References

  1. Subei AM, Ontaneda D. Risk mitigation strategies for adverse reactions associated with the disease-modifying drugs in multiple sclerosis. CNS Drugs. 2015;29(9):759–71.

    Article  CAS  PubMed  Google Scholar 

  2. Vartanian T. An examination of the results of the EVIDENCE, INCOMIN, and phase III studies of interferon beta products in the treatment of multiple sclerosis. Clin Ther. 2003;25(1):105–18.

    Article  CAS  PubMed  Google Scholar 

  3. Klawiter EC, Cross AH, Naismith RT. The present efficacy of multiple sclerosis therapeutics: is the new 66 % just the old 33%? Neurology. 2009;73(12):984–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Cohen JA, Barkhof F, Comi G, et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med. 2010;362(5):402–15.

    Article  CAS  PubMed  Google Scholar 

  5. Vermersch P, Czlonkowska A, Grimaldi LM, et al. Teriflunomide versus subcutaneous interferon beta-1a in patients with relapsing multiple sclerosis: a randomised, controlled phase 3 trial. Mult Scler. 2014;20(6):705–16.

    Article  CAS  PubMed  Google Scholar 

  6. Fox RJ, Miller DH, Phillips JT, et al. Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. N Engl J Med. 2012;367(12):1087–97.

    Article  CAS  PubMed  Google Scholar 

  7. Freedman MS, Selchen D, Arnold DL, et al. Treatment optimization in MS: Canadian MS Working Group updated recommendations. Can J Neurol Sci. 2013;40(3):307–23.

    Article  PubMed  Google Scholar 

  8. Kappos L, O’Connor P, Radue EW, et al. Long-term effects of fingolimod in multiple sclerosis: the randomized FREEDOMS extension trial. Neurology. 2015;84(15):1582–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Young PJ, Lederer C, Eder K, et al. Relapses and subsequent worsening of disability in relapsing-remitting multiple sclerosis. Neurology. 2006;67(5):804–8.

    Article  CAS  PubMed  Google Scholar 

  10. Ontaneda D, Fox RJ, Chataway J. Clinical trials in progressive multiple sclerosis: lessons learned and future perspectives. Lancet Neurol. 2015;14(2):208–23.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Cocco E, Marrosu MG. The current role of mitoxantrone in the treatment of multiple sclerosis. Expert Rev Neurother. 2014;14(6):607–16.

    Article  CAS  PubMed  Google Scholar 

  12. Goffette S, van Pesch V, Vanoverschelde JL, et al. Severe delayed heart failure in three multiple sclerosis patients previously treated with mitoxantrone. J Neurol. 2005;252(10):1217–22.

    Article  CAS  PubMed  Google Scholar 

  13. Ellis R, Brown S, Boggild M. Therapy-related acute leukaemia with mitoxantrone: four years on, what is the risk and can it be limited? Mult Scler. 2015;21(5):642–5.

    Article  CAS  PubMed  Google Scholar 

  14. Plavina T, Subramanyam M, Bloomgren G, et al. Anti-JC virus antibody levels in serum or plasma further define risk of natalizumab-associated progressive multifocal leukoencephalopathy. Ann Neurol. 2014;76(6):802–12.

    Article  CAS  PubMed  Google Scholar 

  15. Clifford DB, De Luca A, Simpson DM, et al. Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: lessons from 28 cases. Lancet Neurol. 2010;9(4):438–46.

    Article  CAS  PubMed  Google Scholar 

  16. Confavreux C, O’Connor P, Comi G, et al. Oral teriflunomide for patients with relapsing multiple sclerosis (TOWER): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Neurol. 2014;13(3):247–56.

    Article  CAS  PubMed  Google Scholar 

  17. O’Connor P, Wolinsky JS, Confavreux C, et al. Randomized trial of oral teriflunomide for relapsing multiple sclerosis. N Engl J Med. 2011;365(14):1293–303.

    Article  PubMed  Google Scholar 

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The article was adapted from CNS Drugs 2015;29(9):759–71 [1] by salaried/contracted employees of Adis/Springer and was not supported by any external funding.

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Adis Medical Writers. Reduce the risk of adverse events associated with disease-modifying therapies for multiple sclerosis by following appropriate mitigation strategies. Drugs Ther Perspect 32, 197–202 (2016). https://doi.org/10.1007/s40267-016-0293-6

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  • DOI: https://doi.org/10.1007/s40267-016-0293-6

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