Abstract
Treatment of cutaneous sarcoidosis is associated with substantial improvements in the condition in clinical practice; however, robust clinical trial data regarding the efficacy of various treatments are lacking. Topical agents should be considered first-line options in all patients, with the addition of systemic immunomodulators and/or immunosuppressants if required.
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Wanat KA, Rosenbach M. A practical approach to cutaneous sarcoidosis. Am J Clin Dermatol. 2014;15(4):283–97.
Rybicki BA, Iannuzzi MC. Epidemiology of sarcoidosis: recent advances and future prospects. Semin Respir Crit Care Med. 2007;28(1):22–35.
Rybicki BA, Maliarik MJ, Major M, et al. Epidemiology, demographics, and genetics of sarcoidosis. Semin Respir Infect. 1998;13(3):166–73.
Iannuzzi MC, Fontana JR. Sarcoidosis: clinical presentation, immunopathogenesis, and therapeutics. JAMA. 2011;305(4):391–9.
Haimovic A, Sanchez M, Judson MA, et al. Sarcoidosis: a comprehensive review and update for the dermatologist: part I. Cutaneous disease. J Am Acad Dermatol. 2012;66(5):699. e1–18.
Haimovic A, Sanchez M, Judson MA, et al. Sarcoidosis: a comprehensive review and update for the dermatologist: part II. Extracutaneous disease. J Am Acad Dermatol. 2012;66(5):719. e1–10.
Marcoval J, Mañá J, Rubio M. Specific cutaneous lesions in patients with systemic sarcoidosis: relationship to severity and chronicity of disease. Clin Exp Dermatol. 2011;36(7):734–44.
Volden G. Successful treatment of chronic skin diseases with clobetasol propionate and a hydrocolloid occlusive dressing. Acta Derm Venereol. 1992;72(1):69–71.
Callen JP. Intralesional corticosteroids. J Am Acad Dermatol. 1981;4(2):149–51.
Katoh N, Mihara H, Yasuno H. Cutaneous sarcoidosis successfully treated with topical tacrolimus. Br J Dermatol. 2002;147(1):154–6.
Penrose C, Mercer SE, Shim-Chang H. Photodynamic therapy for the treatment of cutaneous sarcoidosis. J Am Acad Dermatol. 2011;65(1):e12–4.
Kondo C, Watanabe D, Nakaseko H, et al. Photodynamic therapy for recurrent sarcoid flexor tenosynovitis of the finger. J Am Acad Dermatol. 2006;55(5 Suppl):S99–101.
Holzmann RD, Astner S, Forschner T, et al. Scar sarcoidosis in a child: case report of successful treatment with the pulsed dye laser. Dermatol Surg. 2008;34(3):393–6.
Green JJ, Lawrence N, Heymann WR. Generalized ulcerative sarcoidosis induced by therapy with the flashlamp-pumped pulsed dye laser. Arch Dermatol. 2001;137(4):507–8.
Roos S, Raulin C, Ockenfels HM, et al. Successful treatment of cutaneous sarcoidosis lesions with the flashlamp pumpled pulsed dye laser: a case report. Dermatol Surg. 2009;35(7):1139–40.
Gleeson CM, Morar N, Staveley I, et al. Treatment of cutaneous sarcoid with topical gel psoralen and ultraviolet A. Br J Dermatol. 2011;164(4):892–4.
Modi S, Rosen T. Micropapular cutaneous sarcoidosis: case series successfully managed with hydroxychloroquine sulfate. Cutis. 2008;81(4):351–4.
Zic JA, Horowitz DH, Arzubiaga C, et al. Treatment of cutaneous sarcoidosis with chloroquine: review of the literature. Arch Dermatol. 1991;127(7):1034–40.
Bachelez H, Senet P, Cadranet J, et al. The use of tetracyclines for the treatment of sarcoidosis. Arch Dermatol. 2001;137(1):69–73.
Park MK, Fontana JR, Babaali H, et al. Steroid-sparing effects of pentoxifylline in pulmonary sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2009;26(2):121–31.
Baughman RP, Judson MA, Ingledue R, et al. Efficacy and safety of apremilast in chronic cutaneous sarcoidosis. Arch Dermatol. 2012;148(2):262–4.
Badgwell C, Rosen T. Cutaneous sarcoidosis therapy updated. J Am Acad Dermatol. 2007;56(1):69–83.
Baughman RP, Nunes H. Therapy for sarcoidosis: evidence-based recommendations. Expert Rev Clin Immunol. 2012;8(1):95–103.
Fazzi P, Manni E, Cristofani R, et al. Thalidomide for improving cutaneous and pulmonary sarcoidosis in patients resistant or with contraindications to corticosteroids. Biomed Pharmacother. 2012;66(4):300–4.
Tu J, Chan J. Cutaneous sarcoidosis and infliximab: evidence for efficacy in refractory disease. Australas J Dermatol. 2013. doi:10.1111/ajd.12056.
Thielen AM, Barde C, Saurat JH, et al. Refractory chronic cutaneous sarcoidosis responsive to dose escalation of TNF-alpha antagonists. Dermatology. 2009;219(1):59–62.
Stagaki E, Mountford WK, Lackland DT, et al. The treatment of lupus pernio: results of 116 treatment courses in 54 patients. Chest. 2009;135(2):468–76.
Pariser RJ, Paul J, Hirano S, et al. A double-blind, randomized, placebo-controlled trial of adalimumab in the treatment of cutaneous sarcoidosis. J Am Acad Dermatol. 2013;68(5):765–73.
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This article was adapted from the American Journal of Clinical Dermatology 2014;15(4):283–97 [1] by salaried/contracted employees of Adis/Springer, and was not supported by any external funding.
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Adis Medical Writers. Use a stepwise approach when selecting treatment for cutaneous sarcoidosis. Drugs Ther Perspect 31, 23–26 (2015). https://doi.org/10.1007/s40267-014-0168-7
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DOI: https://doi.org/10.1007/s40267-014-0168-7