Abstract
The aim of this study was to introduce new ionic liquid (IL)-based microemulsions and microemulgels as topical delivery systems for celecoxib. Ex-vivo diffusion of celecoxib loaded in IL-based microemulsions and microemulgels through the rat skin by using Franz diffusion cell was investigated and compared with traditional microemulsions. The investigated systems composed of the same nonionic surfactant/co-surfactant of tween-80/transcutol®P, and different oil phases of [BMIM][PF6], [OMIM][PF6] and isopropyl myristate, for construction of ILs/W and O/W microemulsions. The particle size of the ILs/W and O/W microemulsion systems was determined by DLS method. The ex-vivo release results of ILs/W and O/W formulations, at similar conditions, showed that the celecoxib permeability of the ILs/W formulations is more than that of the O/W formulation, either as microemulsion or as microemulgel. As an interesting result, the celecoxib release percent and release rate from the ILs/W systems was more and faster than the O/W system. The kinetic mechanism for ILs/W systems had followed from first-order model and for O/W systems followed Higuchi zero-order model.
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The financial support from Arak University Research Council is gratefully acknowledged (Grant No. 97-37).
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Salabat, A., Parsi, E. Ex vivo evaluation of celecoxib release from ionic liquid-based microemulsions and microemulgels for topical applications. J IRAN CHEM SOC 18, 1355–1361 (2021). https://doi.org/10.1007/s13738-020-02122-7
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DOI: https://doi.org/10.1007/s13738-020-02122-7