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Epigenetic modulation of ferroptosis in cancer: Identifying epigenetic targets for novel anticancer therapy

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Abstract

Ferroptosis is a newly recognized form of oxidative-regulated cell death resulting from iron-mediated lipid peroxidation accumulation. Radical-trapping antioxidant systems can eliminate these oxidized lipids and prevent disrupting the integrity of cell membranes. Epigenetic modifications can regulate ferroptosis by altering gene expression or cell phenotype without permanent sequence changes. These mechanisms include DNA methylation, histone modifications, RNA modifications, and noncoding RNAs. Epigenetic alterations in cancer can control the expression of ferroptosis regulators or related pathways, leading to changes in cell sensitivity to ferroptosis inducers or cancer progression. Epigenetic alterations in cancer are influenced by a wide range of cancer hallmarks, contributing to therapeutic resistance. Targeting epigenetic alterations is a promising approach to overcoming cancer resilience. However, the exact mechanisms involved in different types of cancer remain unresolved. Discovering more ferroptosis-associated epigenetic targets and interventions can help overcome current barriers in anticancer therapy. Many papers on epigenetic modifications of ferroptosis have been continuously published, making it essential to summarize the current state-of-the-art in the epigenetic regulation of ferroptosis in human cancer.

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Abbreviations

ACSL4:

Acyl-CoA synthetase long-chain family member 4

ALOX12:

Arachidonate 12-lipoxygenase

AML:

Acute myeloid leukemia

AP-1:

Activator protein-1

ARE:

Antioxidant response element

ATF4:

Activating transcription factor 4

AURKA:

Aurora kinase A

BAP1:

BRCA1‑associated protein‑1

BETf:

Bromodomain and extraterminal domain

BH4 :

Tetrahydrobiopterin

BRD4:

Bromodomain-containing protein 4

ccRCC:

Clear cell renal cell carcinoma

CD44v:

CD44 variant

CDH1:

E-cadherin

ceRNA:

Competing endogenous RNA

CHMP:

Charged multivesicular body protein

CGIs:

CpG islands

CoQ:

Ubiquinone

CoQ10:

Coenzyme Q10

CoQH2 :

Ubiquinol

CoA:

Coenzyme A

circRNAs:

Circular non-coding RNAs

CRC:

Colorectal cancer

DHODH:

Dihydroorotate dehydrogenase

DNMTs:

DNA methyltransferases;

DPP4:

Dipeptidyl-peptidase-4;

EMT:

Epithelial-mesenchymal transition

ESCRT:

Endosomal sorting complexes required for transport

FABP3:

Fatty acid-binding protein 3

FADS2:

Fatty acid desaturase 2

FAS1:

FAS-associated factor 1

FSP1:

Ferroptosis suppressor protein 1

FTH1:

Ferritin heavy chain 1

GBM:

Glioblastoma multiforme

GCH1:

Guanosine triphosphate cyclohydrolase 1

GLUT1:

Glucose transporter type 1

GPX4:

Glutathione peroxidase 4

GSH:

Glutathione

GSSG:

Glutathione disulfide

H2Aub:

Histone H2A monoubiquitylation

HATs:

Histone acetyltransferases

HCC:

Hepatocellular carcinoma

HDACi:

Histone deacetylase inhibitors

HMGCR:

3-Hydroxy-3-methylglutaryl-CoA reductase

HNC:

Head and neck cancer

IDH:

Isocitrate dehydrogenase

iPLA2β:

Ca2+-independent phospholipase A2β

IPP:

Isopentenyl pyrophosphate

IREB2:

Iron-responsive element-binding protein 2

Keap1:

Kelch-like ECH-associated protein 1

5mC:

5-Methylcytosine

lncRNAs:

Long non-coding RNAs

LSH:

Lymphoid-specific helicase

m6A:

N6-Methyladenosine

miRNAs:

MicroRNAs

METTL:

Methyltransferases-like

NADP:

Nicotinamide adenine dinucleotide phosphate

ncRNAs:

Non-coding RNAs

NF2:

Merlin

Nrf2:

Nuclear factor erythroid 2-related factor 2

NSCLC:

Non-small cell lung cancer

OTUB1:

Ubiquitin hydrolase otubain-1

PCBP3:

Poly(rC)-binding protein 3

PUFA:

Polyunsaturated fatty acid

RCD:

Regulated cell death

ROS:

Reactive oxygen species

RTA:

Radical-trapping antioxidant

SCD1:

Stearoyl-coenzyme A desaturase 1

SIRT1:

Sirtuin 1

SLC7A11 (xCT):

Solute carrier family 7 member 11

SLC40A1:

Ferroportin

system xc– :

Cystine/glutamate exchange transporter

SUV39H1:

Suppressor of variegation 3–9 homolog 1

TET:

Ten-eleven translocation

TFR1:

Transferrin receptor 1

References

  1. S. Tulsyan, M. Aftab, S. Sisodiya, A. Khan, A. Chikara, P. Tanwar, S. Hussain, Front. Genet. 13, 885635 (2022). https://doi.org/10.3389/fgene.2022.885635

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. X. Yang, X. Hu, J. Liu, R. Wang, C. Zhang, F. Han, Y. Chen, D. Ma, Biomark. Res. 8, 61 (2020). https://doi.org/10.1186/s40364-020-00244-x

    Article  PubMed  PubMed Central  Google Scholar 

  3. H. Easwaran, H.C. Tsai, S.B. Baylin, Mol. Cell 54, 716–727 (2014). https://doi.org/10.1016/j.molcel.2014.05.015

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Y. Lu, Y.T. Chan, H.Y. Tan, S. Li, N. Wang, Y. Feng, Mol. Cancer 19, 79 (2020). https://doi.org/10.1186/s12943-020-01197-3

    Article  PubMed  PubMed Central  Google Scholar 

  5. B.R. Stockwell, J.P. Friedmann Angeli, H. Bayir, A.I. Bush, M. Conrad, S.J. Dixon, S. Fulda, S. Gascón, S.K. Hatzios, V.E. Kagan, K. Noel, X. Jiang, A. Linkermann, M.E. Murphy, M. Overholtzer, A. Oyagi, G.C. Pagnussat, J. Park, Q. Ran, C.S. Rosenfeld, K. Salnikow, D. Tang, F.M. Torti, S.V. Torti, S. Toyokuni, K.A. Woerpel, D.D. Zhang, Cell 171, 273–285 (2017). https://doi.org/10.1016/j.cell.2017.09.021

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. S.J. Dixon, K.M. Lemberg, M.R. Lamprecht, R. Skouta, E.M. Zaitsev, C.E. Gleason, D.N. Patel, A.J. Bauer, A.M. Cantley, W.S. Yang, B. Morrison 3rd., B.R. Stockwell, Cell 149, 1060–1072 (2012). https://doi.org/10.1016/j.cell.2012.03.042

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. L. Galluzzi, I. Vitale, S.A. Aaronson, J.M. Abrams, D. Adam, P. Agostinis, E.S. Alnemri, L. Altucci, I. Amelio, D.W. Andrews, M. Annicchiarico-Petruzzelli, A.V. Antonov, E. Arama, E.H. Baehrecke, N.A. Barlev, N.G. Bazan, F. Bernassola, M.J.M. Bertrand, K. Bianchi, M.V. Blagosklonny, K. Blomgren, C. Borner, P. Boya, C. Brenner, M. Campanella, E. Candi, D. Carmona-Gutierrez, F. Cecconi, F.K. Chan, N.S. Chandel, E.H. Cheng, J.E. Chipuk, J.A. Cidlowski, A. Ciechanover, G.M. Cohen, M. Conrad, J.R. Cubillos-Ruiz, P.E. Czabotar, V. D’Angiolella, T.M. Dawson, V.L. Dawson, V. De Laurenzi, R. De Maria, K.M. Debatin, R.J. DeBerardinis, M. Deshmukh, N. Di Daniele, F. Di Virgilio, V.M. Dixit, S.J. Dixon, C.S. Duckett, B.D. Dynlacht, W.S. El-Deiry, J.W. Elrod, G.M. Fimia, S. Fulda, A.J. García-Sáez, A.D. Garg, C. Garrido, E. Gavathiotis, P. Golstein, E. Gottlieb, D.R. Green, L.A. Greene, H. Gronemeyer, A. Gross, G. Hajnoczky, J.M. Hardwick, I.S. Harris, M.O. Hengartner, C. Hetz, H. Ichijo, M. Jäättelä, B. Joseph, P.J. Jost, P.P. Juin, W.J. Kaiser, M. Karin, T. Kaufmann, O. Kepp, A. Kimchi, R.N. Kitsis, D.J. Klionsky, R.A. Knight, S. Kumar, S.W. Lee, J.J. Lemasters, B. Levine, A. Linkermann, S.A. Lipton, R.A. Lockshin, C. López-Otín, S.W. Lowe, T. Luedde, E. Lugli, M. MacFarlane, F. Madeo, M. Malewicz, W. Malorni, G. Manic, J.C. Marine, S.J. Martin, J.C. Martinou, J.P. Medema, P. Mehlen, P. Meier, S. Melino, E.A. Miao, J.D. Molkentin, U.M. Moll, C. Muñoz-Pinedo, S. Nagata, G. Nuñez, A. Oberst, M. Oren, M. Overholtzer, M. Pagano, T. Panaretakis, M. Pasparakis, J.M. Penninger, D.M. Pereira, S. Pervaiz, M.E. Peter, M. Piacentini, P. Pinton, J.H.M. Prehn, H. Puthalakath, G.A. Rabinovich, M. Rehm, R. Rizzuto, C.M.P. Rodrigues, D.C. Rubinsztein, T. Rudel, K.M. Ryan, E. Sayan, L. Scorrano, F. Shao, Y. Shi, J. Silke, H.U. Simon, A. Sistigu, B.R. Stockwell, A. Strasser, G. Szabadkai, S.W.G. Tait, D. Tang, N. Tavernarakis, A. Thorburn, Y. Tsujimoto, B. Turk, T. Vanden Berghe, P. Vandenabeele, M.G. Vander Heiden, A. Villunger, H.W. Virgin, K.H. Vousden, D. Vucic, E.F. Wagner, H. Walczak, D. Wallach, Y. Wang, J.A. Wells, W. Wood, J. Yuan, Z. Zakeri, B. Zhivotovsky, L. Zitvogel, G. Melino, G. Kroemer, Cell Death Differ. 25, 486–541 (2018). https://doi.org/10.1038/s41418-017-0012-4

    Article  PubMed  PubMed Central  Google Scholar 

  8. D. Galaris, A. Barbouti, K. Pantopoulos, Biochim. Biophys. Acta Mol. Cell Res. 1866, 118535 (2019). https://doi.org/10.1016/j.bbamcr.2019.118535

    Article  CAS  PubMed  Google Scholar 

  9. H. Feng, B.R. Stockwell, PLoS Biol 16, e2006203 (2018). https://doi.org/10.1371/journal.pbio.2006203

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. H. Bayır, T.S. Anthonymuthu, Y.Y. Tyurina, S.J. Patel, A.A. Amoscato, A.M. Lamade, Q. Yang, G.K. Vladimirov, C.C. Philpott, V.E. Kagan, Cell Chem. Biol. 27, 387–408 (2020). https://doi.org/10.1016/j.chembiol.2020.03.014

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. B. Hassannia, P. Vandenabeele, T. Vanden Berghe, Cancer Cell 35, 830–849 (2019). https://doi.org/10.1016/j.ccell.2019.04.002

    Article  CAS  PubMed  Google Scholar 

  12. Y. Zhang, M. Li, Y. Guo, S. Liu, Y. Tao, Front. Pharmacol. 13, 905501 (2022). https://doi.org/10.3389/fphar.2022.905501

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Y. Wu, S. Zhang, X. Gong, S. Tam, D. Xiao, S. Liu, Y. Tao, Mol Cancer 19, 39 (2020). https://doi.org/10.1186/s12943-020-01157-x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Y. Pei, Y. Qian, H. Wang, L. Tan, Front Oncol 12, 771870 (2022). https://doi.org/10.3389/fonc.2022.771870

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. J. Luo, Y. Hong, Y. Lu, S. Qiu, B.K. Chaganty, L. Zhang, X. Wang, Q. Li, Z. Fan, Cancer Lett. 384, 39–49 (2017). https://doi.org/10.1016/j.canlet.2016.09.020

    Article  CAS  PubMed  Google Scholar 

  16. D. Liang, A.M. Minikes, X. Jiang, Mol. Cell 82, 2215–2227 (2022). https://doi.org/10.1016/j.molcel.2022.03.022

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. S. Doll, B. Proneth, Y.Y. Tyurina, E. Panzilius, S. Kobayashi, I. Ingold, M. Irmler, J. Beckers, M. Aichler, A. Walch, H. Prokisch, D. Trümbach, G. Mao, F. Qu, H. Bayir, J. Füllekrug, C.H. Scheel, W. Wurst, J.A. Schick, V.E. Kagan, J.P. Angeli, M. Conrad, Nat. Chem. Biol. 13, 91–98 (2017). https://doi.org/10.1038/nchembio.2239

    Article  CAS  PubMed  Google Scholar 

  18. D.A. Pratt, K.A. Tallman, N.A. Porter, Acc. Chem. Res. 44, 458–467 (2011). https://doi.org/10.1021/ar200024c

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. T. Nishida Xavier da Silva, J.P. Friedmann Angeli, I. Ingold, Biochem. Soc. Trans. 50, 1205–1213 (2022). https://doi.org/10.1042/bst20220682

    Article  CAS  PubMed  Google Scholar 

  20. X. Liu, Y. Zhang, L. Zhuang, K. Olszewski, B. Gan, Genes Dis. 8, 731–745 (2021). https://doi.org/10.1016/j.gendis.2020.11.010

    Article  CAS  PubMed  Google Scholar 

  21. H. Sato, M. Tamba, K. Kuriyama-Matsumura, S. Okuno, S. Bannai, Antioxid. Redox Signal. 2, 665–671 (2000). https://doi.org/10.1089/ars.2000.2.4-665

    Article  CAS  PubMed  Google Scholar 

  22. W.S. Yang, R. SriRamaratnam, M.E. Welsch, K. Shimada, R. Skouta, V.S. Viswanathan, J.H. Cheah, P.A. Clemons, A.F. Shamji, C.B. Clish, L.M. Brown, A.W. Girotti, V.W. Cornish, S.L. Schreiber, B.R. Stockwell, Cell 156, 317–331 (2014). https://doi.org/10.1016/j.cell.2013.12.010

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. J. Lee, J.L. Roh, Antioxidants (Basel) 11, (2022). https://doi.org/10.3390/antiox11122444

  24. D. Chen, Z. Fan, M. Rauh, M. Buchfelder, I.Y. Eyupoglu, N. Savaskan, Oncogene 36, 5593–5608 (2017). https://doi.org/10.1038/onc.2017.146

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. J.Y. Cao, A. Poddar, L. Magtanong, J.H. Lumb, T.R. Mileur, M.A. Reid, C.M. Dovey, J. Wang, J.W. Locasale, E. Stone, S.P.C. Cole, J.E. Carette, S.J. Dixon, Cell Rep. 26, 1544-1556.e1548 (2019). https://doi.org/10.1016/j.celrep.2019.01.043

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. L. Jiang, N. Kon, T. Li, S.J. Wang, T. Su, H. Hibshoosh, R. Baer, W. Gu, Nature 520, 57–62 (2015). https://doi.org/10.1038/nature14344

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Y. Zhang, J. Shi, X. Liu, L. Feng, Z. Gong, P. Koppula, K. Sirohi, X. Li, Y. Wei, H. Lee, L. Zhuang, G. Chen, Z.D. Xiao, M.C. Hung, J. Chen, P. Huang, W. Li, B. Gan, Nat. Cell Biol. 20, 1181–1192 (2018). https://doi.org/10.1038/s41556-018-0178-0

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. S. Sui, J. Zhang, S. Xu, Q. Wang, P. Wang, D. Pang, Cell Death Dis. 10, 331 (2019). https://doi.org/10.1038/s41419-019-1564-7

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. T. Liu, L. Jiang, O. Tavana, W. Gu, Cancer Res. 79, 1913–1924 (2019). https://doi.org/10.1158/0008-5472.can-18-3037

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. X. Song, S. Zhu, P. Chen, W. Hou, Q. Wen, J. Liu, Y. Xie, J. Liu, D.J. Klionsky, G. Kroemer, M.T. Lotze, H.J. Zeh, R. Kang, D. Tang, Curr. Biol.: CB 28, 2388-2399.e2385 (2018). https://doi.org/10.1016/j.cub.2018.05.094

    Article  CAS  PubMed  Google Scholar 

  31. Y. Gu, C.P. Albuquerque, D. Braas, W. Zhang, G.R. Villa, J. Bi, S. Ikegami, K. Masui, B. Gini, H. Yang, T.C. Gahman, A.K. Shiau, T.F. Cloughesy, H.R. Christofk, H. Zhou, K.L. Guan, P.S. Mischel, Mol. Cell 67, 128-138.e127 (2017). https://doi.org/10.1016/j.molcel.2017.05.030

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. M.A. Badgley, D.M. Kremer, H.C. Maurer, K.E. DelGiorno, H.J. Lee, V. Purohit, I.R. Sagalovskiy, A. Ma, J. Kapilian, C.E.M. Firl, A.R. Decker, S.A. Sastra, C.F. Palermo, L.R. Andrade, P. Sajjakulnukit, L. Zhang, Z.P. Tolstyka, T. Hirschhorn, C. Lamb, T. Liu, W. Gu, E.S. Seeley, E. Stone, G. Georgiou, U. Manor, A. Iuga, G.M. Wahl, B.R. Stockwell, C.A. Lyssiotis, K.P. Olive, Science (New York, N.Y.) 368, 85–89 (2020). https://doi.org/10.1126/science.aaw9872

    Article  CAS  PubMed  Google Scholar 

  33. H. Sato, A. Shiiya, M. Kimata, K. Maebara, M. Tamba, Y. Sakakura, N. Makino, F. Sugiyama, K. Yagami, T. Moriguchi, S. Takahashi, S. Bannai, J. Biol. Chem. 280, 37423–37429 (2005). https://doi.org/10.1074/jbc.M506439200

    Article  CAS  PubMed  Google Scholar 

  34. L.J. Yant, Q. Ran, L. Rao, H. Van Remmen, T. Shibatani, J.G. Belter, L. Motta, A. Richardson, T.A. Prolla, Free Radic. Biol. Med. 34, 496–502 (2003). https://doi.org/10.1016/s0891-5849(02)01360-6

    Article  CAS  PubMed  Google Scholar 

  35. K. Bersuker, J.M. Hendricks, Z. Li, L. Magtanong, B. Ford, P.H. Tang, M.A. Roberts, B. Tong, T.J. Maimone, R. Zoncu, M.C. Bassik, D.K. Nomura, S.J. Dixon, J.A. Olzmann, Nature 575, 688–692 (2019). https://doi.org/10.1038/s41586-019-1705-2

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. S. Doll, F.P. Freitas, R. Shah, M. Aldrovandi, M.C. da Silva, I. Ingold, A. Goya Grocin, T.N. Xavier da Silva, E. Panzilius, C.H. Scheel, A. Mourão, K. Buday, M. Sato, J. Wanninger, T. Vignane, V. Mohana, M. Rehberg, A. Flatley, A. Schepers, A. Kurz, D. White, M. Sauer, M. Sattler, E.W. Tate, W. Schmitz, A. Schulze, V. O’Donnell, B. Proneth, G.M. Popowicz, D.A. Pratt, J.P.F. Angeli, M. Conrad, Nature 575, 693–698 (2019). https://doi.org/10.1038/s41586-019-1707-0

    Article  CAS  PubMed  Google Scholar 

  37. R. Banerjee, J. Purhonen, J. Kallijärvi, FEBS J. (2021). https://doi.org/10.1111/febs.16164

    Article  PubMed  PubMed Central  Google Scholar 

  38. M.M. Santoro, Cell Metab. 31, 13–15 (2020). https://doi.org/10.1016/j.cmet.2019.12.007

    Article  CAS  PubMed  Google Scholar 

  39. S. Boukalova, S. Hubackova, M. Milosevic, Z. Ezrova, J. Neuzil, J. Rohlena, Biochim. Biophys. Acta Mol. Basis Dis. 1866, 165759 (2020). https://doi.org/10.1016/j.bbadis.2020.165759

    Article  CAS  PubMed  Google Scholar 

  40. Y. Zhou, L. Tao, X. Zhou, Z. Zuo, J. Gong, X. Liu, Y. Zhou, C. Liu, N. Sang, H. Liu, J. Zou, K. Gou, X. Yang, Y. Zhao, Cancer Metab. 9, 22 (2021). https://doi.org/10.1186/s40170-021-00250-z

    Article  PubMed  PubMed Central  Google Scholar 

  41. C. Mao, X. Liu, Y. Zhang, G. Lei, Y. Yan, H. Lee, P. Koppula, S. Wu, L. Zhuang, B. Fang, M.V. Poyurovsky, K. Olszewski, B. Gan, Nature 593, 586–590 (2021). https://doi.org/10.1038/s41586-021-03539-7

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. V.A.N. Kraft, C.T. Bezjian, S. Pfeiffer, L. Ringelstetter, C. Müller, F. Zandkarimi, J. Merl-Pham, X. Bao, N. Anastasov, J. Kössl, S. Brandner, J.D. Daniels, P. Schmitt-Kopplin, S.M. Hauck, B.R. Stockwell, K. Hadian, J.A. Schick, ACS Cent. Sci. 6, 41–53 (2020). https://doi.org/10.1021/acscentsci.9b01063

    Article  CAS  PubMed  Google Scholar 

  43. Q. Hu, W. Wei, D. Wu, F. Huang, M. Li, W. Li, J. Yin, Y. Peng, Y. Lu, Q. Zhao, L. Liu, Front. Cell Dev. Biol. 10, 810327 (2022). https://doi.org/10.3389/fcell.2022.810327

    Article  PubMed  PubMed Central  Google Scholar 

  44. V.S. Viswanathan, M.J. Ryan, H.D. Dhruv, S. Gill, O.M. Eichhoff, B. Seashore-Ludlow, S.D. Kaffenberger, J.K. Eaton, K. Shimada, A.J. Aguirre, S.R. Viswanathan, S. Chattopadhyay, P. Tamayo, W.S. Yang, M.G. Rees, S. Chen, Z.V. Boskovic, S. Javaid, C. Huang, X. Wu, Y.Y. Tseng, E.M. Roider, D. Gao, J.M. Cleary, B.M. Wolpin, J.P. Mesirov, D.A. Haber, J.A. Engelman, J.S. Boehm, J.D. Kotz, C.S. Hon, Y. Chen, W.C. Hahn, M.P. Levesque, J.G. Doench, M.E. Berens, A.F. Shamji, P.A. Clemons, B.R. Stockwell, S.L. Schreiber, Nature 547, 453–457 (2017). https://doi.org/10.1038/nature23007

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. J.P.F. Angeli, F.P. Freitas, P. Nepachalovich, L. Puentes, O. Zika, A. Inague, S. Lorenz, Preprint in Research Square, (2021). https://doi.org/10.21203/rs.3.rs-943221/v1

  46. O. Beharier, V.A. Tyurin, J.P. Goff, J. Guerrero-Santoro, K. Kajiwara, T. Chu, Y.Y. Tyurina, C.M. St Croix, C.T. Wallace, S. Parry, W.T. Parks, V.E. Kagan, Y. Sadovsky, Proc. Natl. Acad. Sci. U. S. A. 117, 27319–27328 (2020). https://doi.org/10.1073/pnas.2009201117

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. W.Y. Sun, V.A. Tyurin, K. Mikulska-Ruminska, I.H. Shrivastava, T.S. Anthonymuthu, Y.J. Zhai, M.H. Pan, H.B. Gong, D.H. Lu, J. Sun, W.J. Duan, S. Korolev, A.Y. Abramov, P.R. Angelova, I. Miller, O. Beharier, G.W. Mao, H.H. Dar, A.A. Kapralov, A.A. Amoscato, T.G. Hastings, T.J. Greenamyre, C.T. Chu, Y. Sadovsky, I. Bahar, H. Bayır, Y.Y. Tyurina, R.R. He, V.E. Kagan, Nat. Chem. Biol. 17, 465–476 (2021). https://doi.org/10.1038/s41589-020-00734-x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. D. Chen, B. Chu, X. Yang, Z. Liu, Y. Jin, N. Kon, R. Rabadan, X. Jiang, B.R. Stockwell, W. Gu, Nat. Commun. 12, 3644 (2021). https://doi.org/10.1038/s41467-021-23902-6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. E. Dai, L. Meng, R. Kang, X. Wang, D. Tang, Biochem. Biophys. Res. Commun. 522, 415–421 (2020). https://doi.org/10.1016/j.bbrc.2019.11.110

    Article  CAS  PubMed  Google Scholar 

  50. L. Pedrera, R.A. Espiritu, U. Ros, J. Weber, A. Schmitt, J. Stroh, S. Hailfinger, S. von Karstedt, A.J. García-Sáez, Cell Death Differ. 28, 1644–1657 (2021). https://doi.org/10.1038/s41418-020-00691-x

    Article  CAS  PubMed  Google Scholar 

  51. S. Cui, G. Simmons Jr., G. Vale, Y. Deng, J. Kim, H. Kim, R. Zhang, J.G. McDonald, J. Ye, Proc. Natl. Acad. Sci. U. S. A. 119, e2107189119 (2022). https://doi.org/10.1073/pnas.2107189119

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. M. Rojo de la Vega, E. Chapman, D.D. Zhang, Cancer Cell 34, 21–43 (2018). https://doi.org/10.1016/j.ccell.2018.03.022

    Article  CAS  PubMed  Google Scholar 

  53. A. Anandhan, M. Dodson, C.J. Schmidlin, P. Liu, D.D. Zhang, Cell Chem. Biol. 27, 436–447 (2020). https://doi.org/10.1016/j.chembiol.2020.03.011

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. H. Nishizawa, M. Matsumoto, T. Shindo, D. Saigusa, H. Kato, K. Suzuki, M. Sato, Y. Ishii, H. Shimokawa, K. Igarashi, J. Biol. Chem. 295, 69–82 (2020). https://doi.org/10.1074/jbc.RA119.009548

    Article  CAS  PubMed  Google Scholar 

  55. H. Nishizawa, M. Yamanaka, K. Igarashi, FEBS J 290, 1688–1704 (2023). https://doi.org/10.1111/febs.16382

    Article  CAS  PubMed  Google Scholar 

  56. P. Koppula, G. Lei, Y. Zhang, Y. Yan, C. Mao, L. Kondiparthi, J. Shi, X. Liu, A. Horbath, M. Das, W. Li, M.V. Poyurovsky, K. Olszewski, B. Gan, Nat. Commun. 13, 2206 (2022). https://doi.org/10.1038/s41467-022-29905-1

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. L. Wang, S. Ouyang, B. Li, H. Wu, F. Wang, Cell Death Discov. 7, 334 (2021). https://doi.org/10.1038/s41420-021-00726-3

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. D.S. Liu, C.P. Duong, S. Haupt, K.G. Montgomery, C.M. House, W.J. Azar, H.B. Pearson, O.M. Fisher, M. Read, G.R. Guerra, Y. Haupt, C. Cullinane, K.G. Wiman, L. Abrahmsen, W.A. Phillips, N.J. Clemons, Nat. Commun. 8, 14844 (2017). https://doi.org/10.1038/ncomms14844

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. T. Li, N. Kon, L. Jiang, M. Tan, T. Ludwig, Y. Zhao, R. Baer, W. Gu, Cell 149, 1269–1283 (2012). https://doi.org/10.1016/j.cell.2012.04.026

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. S.J. Wang, D. Li, Y. Ou, L. Jiang, Y. Chen, Y. Zhao, W. Gu, Cell Rep. 17, 366–373 (2016). https://doi.org/10.1016/j.celrep.2016.09.022

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. B. Chu, N. Kon, D. Chen, T. Li, T. Liu, L. Jiang, S. Song, O. Tavana, W. Gu, Nat. Cell Biol. 21, 579–591 (2019). https://doi.org/10.1038/s41556-019-0305-6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. S.C. Wu, Y. Zhang, Nat. Rev. Mol. Cell Biology 11, 607–620 (2010). https://doi.org/10.1038/nrm2950

    Article  CAS  Google Scholar 

  63. Y. Xu, M. Hong, D. Kong, J. Deng, Z. Zhong, J. Liang, BMC Genomics 23, 63 (2022). https://doi.org/10.1186/s12864-022-08296-z

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. P. López-Nieva, I. González-Vasconcellos, L. González-Sánchez, M.A. Cobos-Fernández, S. Ruiz-García, R. Sánchez Pérez, Á. Aroca, J. Fernández-Piqueras, J. Santos, Sci. Rep. 12, 3144 (2022). https://doi.org/10.1038/s41598-022-07166-8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. W. Li, W. Li, Y. Wang, Y. Leng, Z. Xia, Cell Death Discov. 7, 267 (2021). https://doi.org/10.1038/s41420-021-00656-0

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Y. Jiang, C. Mao, R. Yang, B. Yan, Y. Shi, X. Liu, W. Lai, Y. Liu, X. Wang, D. Xiao, H. Zhou, Y. Cheng, F. Yu, Y. Cao, S. Liu, Q. Yan, Y. Tao, Theranostics 7, 3293–3305 (2017). https://doi.org/10.7150/thno.19988

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. W.J. Jeong, J.C. Park, W.S. Kim, E.J. Ro, S.H. Jeon, S.K. Lee, Y.N. Park, D.S. Min, K.Y. Choi, Nat. Commun. 10, 295 (2019). https://doi.org/10.1038/s41467-018-08230-6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. E.L. LaGory, A.J. Giaccia, Nat. Cell Biol. 18, 356–365 (2016). https://doi.org/10.1038/ncb3330

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. L.B. Pontel, A. Bueno-Costa, A.E. Morellato, J. Carvalho Santos, G. Roué, M. Esteller, Redox Biol 55, 102408 (2022). https://doi.org/10.1016/j.redox.2022.102408

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. M.J. Hangauer, V.S. Viswanathan, M.J. Ryan, D. Bole, J.K. Eaton, A. Matov, J. Galeas, H.D. Dhruv, M.E. Berens, S.L. Schreiber, F. McCormick, M.T. McManus, Nature 551, 247–250 (2017). https://doi.org/10.1038/nature24297

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  71. T. Sun, J.T. Chi, Genes Dis. 8, 241–249 (2021). https://doi.org/10.1016/j.gendis.2020.05.004

    Article  CAS  PubMed  Google Scholar 

  72. J. Wu, A.M. Minikes, M. Gao, H. Bian, Y. Li, B.R. Stockwell, Z.N. Chen, X. Jiang, Nature 572, 402–406 (2019). https://doi.org/10.1038/s41586-019-1426-6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. J. Lee, J.H. You, M.S. Kim, J.L. Roh, Redox Biol 37, 101697 (2020). https://doi.org/10.1016/j.redox.2020.101697

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. X. Zhang, Z. Huang, Z. Xie, Y. Chen, Z. Zheng, X. Wei, B. Huang, Z. Shan, J. Liu, S. Fan, J. Chen, F. Zhao, Free Radic. Biol. Med. 160, 552–565 (2020). https://doi.org/10.1016/j.freeradbiomed.2020.08.029

    Article  CAS  PubMed  Google Scholar 

  75. A. Seethy, K. Pethusamy, I. Chattopadhyay, R. Sah, A. Chopra, R. Dhar, S. Karmakar, Appl. Biochem. Biotechnol. 193, 1701–1726 (2021). https://doi.org/10.1007/s12010-021-03537-5

    Article  CAS  PubMed  Google Scholar 

  76. S. Ito, L. Shen, Q. Dai, S.C. Wu, L.B. Collins, J.A. Swenberg, C. He, Y. Zhang, Science 333, 1300–1303 (2011). https://doi.org/10.1126/science.1210597

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. E.M. Michalak, M.L. Burr, A.J. Bannister, M.A. Dawson, Nat. Rev. Mol. Cell Biol. 20, 573–589 (2019). https://doi.org/10.1038/s41580-019-0143-1

    Article  CAS  PubMed  Google Scholar 

  78. M.D. Ricketts, J. Han, M.R. Szurgot, R. Marmorstein, Protein Sci. 28, 329–343 (2019). https://doi.org/10.1002/pro.3535

    Article  CAS  PubMed  Google Scholar 

  79. A.J. Bannister, T. Kouzarides, Cell Res. 21, 381–395 (2011). https://doi.org/10.1038/cr.2011.22

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. J.S. Becker, D. Nicetto, K.S. Zaret, Trends Genet. 32, 29–41 (2016). https://doi.org/10.1016/j.tig.2015.11.001

    Article  CAS  PubMed  Google Scholar 

  81. J. Wang, X. Yin, W. He, W. Xue, J. Zhang, Y. Huang, Acta Pharm. Sin. B 11, 406–419 (2021). https://doi.org/10.1016/j.apsb.2020.09.015

    Article  CAS  PubMed  Google Scholar 

  82. Y. Xie, S. Zhu, X. Song, X. Sun, Y. Fan, J. Liu, M. Zhong, H. Yuan, L. Zhang, T.R. Billiar, M.T. Lotze, H.J. Zeh 3rd., R. Kang, G. Kroemer, D. Tang, Cell Rep. 20, 1692–1704 (2017). https://doi.org/10.1016/j.celrep.2017.07.055

    Article  CAS  PubMed  Google Scholar 

  83. Y. Wang, Y. Zhao, H. Wang, C. Zhang, M. Wang, Y. Yang, X. Xu, Z. Hu, FEBS Open Bio 10, 637–643 (2020). https://doi.org/10.1002/2211-5463.12823

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  84. M. Chen, Y. Jiang, Y. Sun, Biochem. Biophys. Res. Commun. 550, 77–83 (2021). https://doi.org/10.1016/j.bbrc.2021.02.137

    Article  CAS  PubMed  Google Scholar 

  85. M.J. Edelmann, A. Iphöfer, M. Akutsu, M. Altun, K. di Gleria, H.B. Kramer, E. Fiebiger, S. Dhe-Paganon, B.M. Kessler, Biochem. J. 418, 379–390 (2009). https://doi.org/10.1042/bj20081318

    Article  CAS  PubMed  Google Scholar 

  86. Y. Wang, L. Yang, X. Zhang, W. Cui, Y. Liu, Q.R. Sun, Q. He, S. Zhao, G.A. Zhang, Y. Wang, S. Chen, EMBO Rep 20, e47563 (2019). https://doi.org/10.15252/embr.201847563

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  87. X. Zhao, M. Zhou, Y. Yang, M. Luo, Bioengineered 12, 12636–12645 (2021). https://doi.org/10.1080/21655979.2021.2011633

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. X. Wang, Y. Chen, X. Wang, H. Tian, Y. Wang, J. Jin, Z. Shan, Y. Liu, Z. Cai, X. Tong, Y. Luan, X. Tan, B. Luan, X. Ge, H. Ji, X. Jiang, P. Wang, Cancer Res. 81, 5217–5229 (2021). https://doi.org/10.1158/0008-5472.Can-21-0567

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  89. K. Struhl, Genes Dev. 12, 599–606 (1998). https://doi.org/10.1101/gad.12.5.599

    Article  CAS  PubMed  Google Scholar 

  90. R. Marmorstein, M.M. Zhou, Cold Spring Harb. Perspect. Biol. 6, a018762 (2014). https://doi.org/10.1101/cshperspect.a018762

    Article  PubMed  PubMed Central  Google Scholar 

  91. J. Zeng, J. Guo, S. Huang, Y. Cheng, F. Luo, X. Xu, R. Chen, G. Ma, Y. Wang, Front. Physiol. 14, 1131201 (2023). https://doi.org/10.3389/fphys.2023.1131201

    Article  PubMed  PubMed Central  Google Scholar 

  92. X. Jiang, B. Liu, Z. Nie, L. Duan, Q. Xiong, Z. Jin, C. Yang, Y. Chen, Signal Transduct. Target. Ther. 6, 74 (2021). https://doi.org/10.1038/s41392-020-00450-x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  93. X.Y. Chen, J. Zhang, J.S. Zhu, Mol. Cancer 18, 103 (2019). https://doi.org/10.1186/s12943-019-1033-z

    Article  PubMed  PubMed Central  Google Scholar 

  94. H. Huang, H. Weng, J. Chen, Cancer Cell 37, 270–288 (2020). https://doi.org/10.1016/j.ccell.2020.02.004

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  95. Y. Xu, X.D. Yuan, J.J. Wu, R.Y. Chen, L. Xia, M. Zhang, C.H. Han, S. Mou, J. Cell Biochem. 121, 524–533 (2020). https://doi.org/10.1002/jcb.29258

    Article  CAS  PubMed  Google Scholar 

  96. L. Ma, T. Chen, X. Zhang, Y. Miao, X. Tian, K. Yu, X. Xu, Y. Niu, S. Guo, C. Zhang, S. Qiu, Y. Qiao, W. Fang, L. Du, Y. Yu, J. Wang, Redox Biol 38, 101801 (2021). https://doi.org/10.1016/j.redox.2020.101801

    Article  CAS  PubMed  Google Scholar 

  97. F.H. Ji, X.H. Fu, G.Q. Li, Q. He, X.G. Qiu, Front. Endocrinol. (Lausanne) 13, 857765 (2022). https://doi.org/10.3389/fendo.2022.857765

    Article  PubMed  Google Scholar 

  98. W.M. Huang, Z.X. Li, Y.H. Wu, Z.L. Shi, J.L. Mi, K. Hu, R.S. Wang, Transl. Oncol. 27, 101576 (2022). https://doi.org/10.1016/j.tranon.2022.101576

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  99. P. Zhang, W. Wu, Q. Chen, M. Chen, J. Integr. Bioinform. 16, (2019). https://doi.org/10.1515/jib-2019-0027

  100. A.F. Palazzo, E.V. Koonin, Cell 183, 1151–1161 (2020). https://doi.org/10.1016/j.cell.2020.09.047

    Article  CAS  PubMed  Google Scholar 

  101. B. Chen, M.P. Dragomir, C. Yang, Q. Li, D. Horst, G.A. Calin, Signal Transduct. Target. Ther. 7, 121 (2022). https://doi.org/10.1038/s41392-022-00975-3

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  102. J. Wu, S. Zhu, P. Wang, J. Wang, J. Huang, T. Wang, L. Guo, D. Liang, Q. Meng, H. Pan, Oncol. Rep. 48, (2022). https://doi.org/10.3892/or.2022.8430

  103. D.P. Bartel, Cell 173, 20–51 (2018). https://doi.org/10.1016/j.cell.2018.03.006

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  104. G.A. Calin, C.D. Dumitru, M. Shimizu, R. Bichi, S. Zupo, E. Noch, H. Aldler, S. Rattan, M. Keating, K. Rai, L. Rassenti, T. Kipps, M. Negrini, F. Bullrich, C.M. Croce, Proc. Natl. Acad. Sci. U. S. A. 99, 15524–15529 (2002). https://doi.org/10.1073/pnas.242606799

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  105. B.M. Hussen, H.J. Hidayat, A. Salihi, D.K. Sabir, M. Taheri, S. Ghafouri-Fard, Biomed. Pharmacother. 138, 111528 (2021). https://doi.org/10.1016/j.biopha.2021.111528

    Article  CAS  PubMed  Google Scholar 

  106. S.M. Dai, F.J. Li, H.Z. Long, Z.W. Zhou, H.Y. Luo, S.G. Xu, L.C. Gao, Front. Pharmacol. 13, 977062 (2022). https://doi.org/10.3389/fphar.2022.977062

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  107. H. Ni, H. Qin, C. Sun, Y. Liu, G. Ruan, Q. Guo, T. Xi, Y. Xing, L. Zheng, Stem Cell Res. Ther. 12, 325 (2021). https://doi.org/10.1186/s13287-021-02394-7

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  108. P. Yadav, P. Sharma, S. Sundaram, G. Venkatraman, A.K. Bera, D. Karunagaran, Cancer Lett. 522, 211–224 (2021). https://doi.org/10.1016/j.canlet.2021.09.033

    Article  CAS  PubMed  Google Scholar 

  109. Y. Yu, H. MohamedAl-Sharani, B. Zhang, Oral Dis. (2021). https://doi.org/10.1111/odi.14040

    Article  PubMed  Google Scholar 

  110. K. Sun, W. Ren, S. Li, J. Zheng, Y. Huang, K. Zhi, L. Gao, Pathol. Res. Pract. 231, 153778 (2022). https://doi.org/10.1016/j.prp.2022.153778

    Article  CAS  PubMed  Google Scholar 

  111. P. Wu, C. Li, D.M. Ye, K. Yu, Y. Li, H. Tang, G. Xu, S. Yi, Z. Zhang, Aging (Albany NY) 13, 4663–4673 (2021). https://doi.org/10.18632/aging.202518

    Article  CAS  PubMed  Google Scholar 

  112. N. Lyu, Y. Zeng, Y. Kong, Q. Chen, H. Deng, S. Ou, Y. Bai, H. Tang, X. Wang, M. Zhao, Ann. Transl. Med. 9, 675 (2021). https://doi.org/10.21037/atm-21-997

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  113. X. Jiang, S. Guo, M. Xu, B. Ma, R. Liu, Y. Xu, Y. Zhang, Front. Oncol. 12, 862015 (2022). https://doi.org/10.3389/fonc.2022.862015

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  114. Y.Z. Li, H.C. Zhu, Y. Du, H.C. Zhao, L. Wang, Technol. Cancer Res. Treat. 21, 15330338221077804 (2022). https://doi.org/10.1177/15330338221077803

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  115. L. Liu, H. Yao, X. Zhou, J. Chen, G. Chen, X. Shi, G. Wu, G. Zhou, S. He, Mol. Carcinog. 61, 301–310 (2022). https://doi.org/10.1002/mc.23367

    Article  CAS  PubMed  Google Scholar 

  116. Y. Yang, Z. Lin, Z. Han, Z. Wu, J. Hua, R. Zhong, R. Zhao, H. Ran, K. Qu, H. Huang, H. Tang, J. Huang, Z. Liu, X. Hong, Z. Peng, G. Zhuang, Cell Death Discov. 7, 272 (2021). https://doi.org/10.1038/s41420-021-00659-x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  117. A. Gomaa, D. Peng, Z. Chen, M. Soutto, K. Abouelezz, A. Corvalan, W. El-Rifai, Sci. Rep. 9, 16970 (2019). https://doi.org/10.1038/s41598-019-53174-6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  118. S.H. Deng, D.M. Wu, L. Li, T. Liu, T. Zhang, J. Li, Y. Yu, M. He, Y.Y. Zhao, R. Han, Y. Xu, Biochem. Biophys. Res. Commun. 549, 54–60 (2021). https://doi.org/10.1016/j.bbrc.2021.02.077

    Article  CAS  PubMed  Google Scholar 

  119. Z. Xu, L. Chen, C. Wang, L. Zhang, W. Xu, Free Radic. Res. 55, 1119–1129 (2021). https://doi.org/10.1080/10715762.2021.2024816

    Article  CAS  PubMed  Google Scholar 

  120. P. Xu, Y. Wang, Z. Deng, Z. Tan, X. Pei, Oncol. Lett. 23, 67 (2022). https://doi.org/10.3892/ol.2022.13186

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  121. Q. Xu, L. Zhou, G. Yang, F. Meng, Y. Wan, L. Wang, L. Zhang, Cell Biol. Int. 44, 2344–2356 (2020). https://doi.org/10.1002/cbin.11444

    Article  CAS  PubMed  Google Scholar 

  122. W. Shanshan, M. Hongying, F. Jingjing, Y. Yiming, R. Yu, Y. Rui, Front. Genet. 12, 743505 (2021). https://doi.org/10.3389/fgene.2021.743505

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  123. B. Han, Y. Liu, Q. Zhang, L. Liang, J. Proteomics, 104777 (2022). https://doi.org/10.1016/j.jprot.2022.104777

  124. Z. Song, G. Jia, P. Ma, S. Cang, Life Sci. 276, 119399 (2021). https://doi.org/10.1016/j.lfs.2021.119399

    Article  CAS  PubMed  Google Scholar 

  125. M. Bazhabayi, X. Qiu, X. Li, A. Yang, W. Wen, X. Zhang, X. Xiao, R. He, P. Liu, J. Cell Mol. Med. 25, 10248–10256 (2021). https://doi.org/10.1111/jcmm.16963

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  126. M. Lu, J. Li, X. Fan, F. Xie, J. Fan, Y. Xiong, Front. Genet. 13, 829384 (2022). https://doi.org/10.3389/fgene.2022.829384

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  127. T. Bai, R. Liang, R. Zhu, W. Wang, L. Zhou, Y. Sun, J. Cell Physiol. 235, 5637–5648 (2020). https://doi.org/10.1002/jcp.29496

    Article  CAS  PubMed  Google Scholar 

  128. L. Guan, F. Wang, M. Wang, S. Han, Z. Cui, S. Xi, H. Xu, S. Li, Oxid. Med. Cell Longev. 2022, 9613095 (2022). https://doi.org/10.1155/2022/9613095

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  129. H. Zhang, T. Deng, R. Liu, T. Ning, H. Yang, D. Liu, Q. Zhang, D. Lin, S. Ge, M. Bai, X. Wang, L. Zhang, H. Li, Y. Yang, Z. Ji, H. Wang, G. Ying, Y. Ba, Mol. Cancer 19, 43 (2020). https://doi.org/10.1186/s12943-020-01168-8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  130. K. Tomita, T. Nagasawa, Y. Kuwahara, S. Torii, K. Igarashi, M.H. Roudkenar, A.M. Roushandeh, A. Kurimasa, T. Sato, Int. J. Mol. Sci. 22, (2021). https://doi.org/10.3390/ijms22158300

  131. X. Yang, J. Liu, C. Wang, K.K. Cheng, H. Xu, Q. Li, T. Hua, X. Jiang, L. Sheng, J. Mao, Z. Liu, Oncogenesis 10, 15 (2021). https://doi.org/10.1038/s41389-021-00304-3

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  132. C. Bao, J. Zhang, S.Y. Xian, F. Chen, Free Radic Res 55, 853–864 (2021). https://doi.org/10.1080/10715762.2021.1962009

    Article  CAS  PubMed  Google Scholar 

  133. L.L. Ma, L. Liang, D. Zhou, S.W. Wang, Neoplasma 68, 165–173 (2021). https://doi.org/10.4149/neo_2020_200707N705

    Article  CAS  PubMed  Google Scholar 

  134. R. Ou, S. Lu, L. Wang, Y. Wang, M. Lv, T. Li, Y. Xu, J. Lu, R.S. Ge, Front. Oncol. 12, 858598 (2022). https://doi.org/10.3389/fonc.2022.858598

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  135. Y. Lu, Y.T. Chan, H.Y. Tan, C. Zhang, W. Guo, Y. Xu, R. Sharma, Z.S. Chen, Y.C. Zheng, N. Wang, Y. Feng, J. Exp. Clin. Cancer Res. 41, 3 (2022). https://doi.org/10.1186/s13046-021-02208-x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  136. G. Bi, J. Liang, M. Zhao, H. Zhang, X. Jin, T. Lu, Y. Zheng, Y. Bian, Z. Chen, Y. Huang, V. Besskaya, C. Zhan, Q. Wang, L. Tan, Mol. Ther. Nucleic Acids 28, 366–386 (2022). https://doi.org/10.1016/j.omtn.2022.03.020

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  137. W. Huang, G. Shi, Z. Yong, J. Li, J. Qiu, Y. Cao, Y. Zhao, L. Yuan, Cell Death Dis. 11, 504 (2020). https://doi.org/10.1038/s41419-020-2695-6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  138. Y. Liao, X. Jia, Y. Ren, Z. Deji, Y. Gesang, N. Ning, H. Feng, H. Yu, A. Wei, Hum. Cell 34, 1532–1544 (2021). https://doi.org/10.1007/s13577-021-00557-5

    Article  CAS  PubMed  Google Scholar 

  139. C. Gai, C. Liu, X. Wu, M. Yu, J. Zheng, W. Zhang, S. Lv, W. Li, Cell Death Dis. 11, 751 (2020). https://doi.org/10.1038/s41419-020-02939-3

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  140. M. Luo, L. Wu, K. Zhang, H. Wang, T. Zhang, L. Gutierrez, D. O’Connell, P. Zhang, Y. Li, T. Gao, W. Ren, Y. Yang, Cell Death Differ. 25, 1457–1472 (2018). https://doi.org/10.1038/s41418-017-0053-8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  141. J. Zhou, C. Sun, X. Dong, H. Wang, J. Mol. Histol. 53, 561–571 (2022). https://doi.org/10.1007/s10735-022-10070-0

    Article  CAS  PubMed  Google Scholar 

  142. M. Gao, J. Yi, J. Zhu, A.M. Minikes, P. Monian, C.B. Thompson, X. Jiang, Mol. Cell 73, 354-363.e353 (2019). https://doi.org/10.1016/j.molcel.2018.10.042

    Article  CAS  PubMed  Google Scholar 

  143. S. Okazaki, K. Umene, J. Yamasaki, K. Suina, Y. Otsuki, M. Yoshikawa, Y. Minami, T. Masuko, S. Kawaguchi, H. Nakayama, K. Banno, D. Aoki, H. Saya, O. Nagano, Cancer Sci. 110, 3453–3463 (2019). https://doi.org/10.1111/cas.14182

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  144. F.J. Xiao, D. Zhang, Y. Wu, Q.H. Jia, L. Zhang, Y.X. Li, Y.F. Yang, H. Wang, C.T. Wu, L.S. Wang, Biochem. Biophys. Res. Commun. 515, 448–454 (2019). https://doi.org/10.1016/j.bbrc.2019.05.147

    Article  CAS  PubMed  Google Scholar 

  145. K. Zhang, L. Wu, P. Zhang, M. Luo, J. Du, T. Gao, D. O’Connell, G. Wang, H. Wang, Y. Yang, Mol. Carcinog. 57, 1566–1576 (2018). https://doi.org/10.1002/mc.22878

    Article  CAS  PubMed  Google Scholar 

  146. S. Zheng, L. Hu, Q. Song, Y. Shan, G. Yin, H. Zhu, W. Kong, C. Zhou, Aging (Albany NY) 13, 26137–26147 (2021). https://doi.org/10.18632/aging.203801

    Article  CAS  PubMed  Google Scholar 

  147. H. Fan, R. Ai, S. Mu, X. Niu, Z. Guo, L. Liu, Bioengineered 13, 12021–12029 (2022). https://doi.org/10.1080/21655979.2022.2054194

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  148. C. Zhu, Z. Song, Z. Chen, T. Lin, H. Lin, Z. Xu, F. Ai, S. Zheng, Anal. Cell Pathol. (Amst) 2022, 4213401 (2022). https://doi.org/10.1155/2022/4213401

    Article  CAS  PubMed  Google Scholar 

  149. P. Xu, F.H. Ge, W.X. Li, Z. Xu, X.L. Wang, J.L. Shen, A.B. Xu, R.R. Hao, Anal. Cell Pathol. (Amst) 2022, 2843990 (2022). https://doi.org/10.1155/2022/2843990

    Article  CAS  PubMed  Google Scholar 

  150. D. Wei, Y.Q. Ke, P. Duan, L. Zhou, C.Y. Wang, P. Cao, Free Radic. Res. 55, 821–830 (2021). https://doi.org/10.1080/10715762.2021.1947503

    Article  CAS  PubMed  Google Scholar 

  151. K. Tomita, M. Fukumoto, K. Itoh, Y. Kuwahara, K. Igarashi, T. Nagasawa, M. Suzuki, A. Kurimasa, T. Sato, Biochem. Biophys. Res. Commun. 518, 712–718 (2019). https://doi.org/10.1016/j.bbrc.2019.08.117

    Article  CAS  PubMed  Google Scholar 

  152. J. Carlevaro-Fita, R. Johnson, Mol. Cell 73, 869–883 (2019). https://doi.org/10.1016/j.molcel.2019.02.008

    Article  CAS  PubMed  Google Scholar 

  153. P. Ji, S. Diederichs, W. Wang, S. Böing, R. Metzger, P.M. Schneider, N. Tidow, B. Brandt, H. Buerger, E. Bulk, M. Thomas, W.E. Berdel, H. Serve, C. Müller-Tidow, Oncogene 22, 8031–8041 (2003). https://doi.org/10.1038/sj.onc.1206928

    Article  CAS  PubMed  Google Scholar 

  154. W. Shi, G. Sethi, J. Cell Physiol. 238, 880–895 (2023). https://doi.org/10.1002/jcp.30992

    Article  CAS  PubMed  Google Scholar 

  155. M. Wang, C. Mao, L. Ouyang, Y. Liu, W. Lai, N. Liu, Y. Shi, L. Chen, D. Xiao, F. Yu, X. Wang, H. Zhou, Y. Cao, S. Liu, Q. Yan, Y. Tao, B. Zhang, Cell Death Differ. 26, 2329–2343 (2019). https://doi.org/10.1038/s41418-019-0304-y

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  156. G.N. He, N.R. Bao, S. Wang, M. Xi, T.H. Zhang, F.S. Chen, Drug Des. Devel. Ther. 15, 3965–3978 (2021). https://doi.org/10.2147/dddt.s332847

    Article  PubMed  PubMed Central  Google Scholar 

  157. Y. Wang, X. Li, W. Chen, W. Wu, Eur. J. Cancer Prev. 30, 389–392 (2021). https://doi.org/10.1097/cej.0000000000000642

    Article  CAS  PubMed  Google Scholar 

  158. S. Lei, W. Cao, Z. Zeng, Z. Zhang, B. Jin, Q. Tian, Y. Wu, T. Zhang, D. Li, C. Hu, J. Lan, J. Zhang, T. Chen, Cell Death Dis. 13, 967 (2022). https://doi.org/10.1038/s41419-022-05412-5

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  159. C. Pan, G. Chen, X. Zhao, X. Xu, J. Liu, Eur. J. Pharmacol. 934, 175317 (2022). https://doi.org/10.1016/j.ejphar.2022.175317

    Article  CAS  PubMed  Google Scholar 

  160. B. Zhang, W. Bao, S. Zhang, B. Chen, X. Zhou, J. Zhao, Z. Shi, T. Zhang, Z. Chen, L. Wang, X. Zheng, G. Chen, Y. Wang, Cell Death Dis. 13, 734 (2022). https://doi.org/10.1038/s41419-022-05173-1

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  161. X. Kang, Y. Huo, S. Jia, F. He, H. Li, Q. Zhou, N. Chang, D. Liu, R. Li, Y. Hu, P. Zhang, A. Xu, Front. Oncol. 12, 939605 (2022). https://doi.org/10.3389/fonc.2022.939605

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  162. J. Hou, Q. Huang, Z. Fan, H. Sang, S. Wu, S. Cheng, Q. Li, Comput. Math. Methods Med. 2022, 8103198 (2022). https://doi.org/10.1155/2022/8103198

    Article  PubMed  PubMed Central  Google Scholar 

  163. L. An, J. Huang, S. Ge, X. Zhang, J. Wang, Comput. Math. Methods Med. 2022, 1972516 (2022). https://doi.org/10.1155/2022/1972516

    Article  PubMed  PubMed Central  Google Scholar 

  164. L. Cai, X. Hu, L. Ye, P. Bai, Y. Jie, K. Shu, Bioengineered 13, 8226–8239 (2022). https://doi.org/10.1080/21655979.2022.2049470

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  165. Y. Zhang, S. Guo, S. Wang, X. Li, D. Hou, H. Li, L. Wang, Y. Xu, B. Ma, H. Wang, X. Jiang, Ecotoxicol. Environ. Saf. 220, 112376 (2021). https://doi.org/10.1016/j.ecoenv.2021.112376

    Article  CAS  PubMed  Google Scholar 

  166. Z. Wang, X. Chen, N. Liu, Y. Shi, Y. Liu, L. Ouyang, S. Tam, D. Xiao, S. Liu, F. Wen, Y. Tao, Mol. Ther. 29, 263–274 (2021). https://doi.org/10.1016/j.ymthe.2020.09.024

    Article  CAS  PubMed  Google Scholar 

  167. S. Li, Z. Lu, R. Sun, S. Guo, F. Gao, B. Cao, J. Aa, Cancers (Basel) 14, (2022). https://doi.org/10.3390/cancers14133059

  168. H. Fu, Z. Zhang, D. Li, Q. Lv, S. Chen, Z. Zhang, M. Wu, Front. Oncol. 12, 817737 (2022). https://doi.org/10.3389/fonc.2022.817737

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  169. C. Mao, X. Wang, Y. Liu, M. Wang, B. Yan, Y. Jiang, Y. Shi, Y. Shen, X. Liu, W. Lai, R. Yang, D. Xiao, Y. Cheng, S. Liu, H. Zhou, Y. Cao, W. Yu, K. Muegge, H. Yu, Y. Tao, Cancer Res. 78, 3484–3496 (2018). https://doi.org/10.1158/0008-5472.can-17-3454

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  170. Y. Han, X. Gao, N. Wu, Y. Jin, H. Zhou, W. Wang, H. Liu, Y. Chu, J. Cao, M. Jiang, S. Yang, Y. Shi, X. Xie, F. Chen, Y. Han, W. Qin, B. Xu, J. Liang, Cell Death Dis. 13, 742 (2022). https://doi.org/10.1038/s41419-022-05192-y

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  171. J. Luo, R. Bai, Y. Liu, H. Bi, X. Shi, C. Qu, Brain Res. Bull. 186, 27–37 (2022). https://doi.org/10.1016/j.brainresbull.2022.04.005

    Article  CAS  PubMed  Google Scholar 

  172. Y. Yang, W. Tai, N. Lu, T. Li, Y. Liu, W. Wu, Z. Li, L. Pu, X. Zhao, T. Zhang, Z. Dong, Aging (Albany NY) 12, 9085–9102 (2020). https://doi.org/10.18632/aging.103176

    Article  CAS  PubMed  Google Scholar 

  173. L. Liu, S. Su, D. Ye, Z. Yu, W. Lu, X. Li, Anticancer Drugs 33, 826–839 (2022). https://doi.org/10.1097/cad.0000000000001328

    Article  CAS  PubMed  Google Scholar 

  174. W. Qi, Z. Li, L. Xia, J. Dai, Q. Zhang, C. Wu, S. Xu, Sci. Rep. 9, 16185 (2019). https://doi.org/10.1038/s41598-019-52837-8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  175. J. Lu, F. Xu, H. Lu, Life Sci. 260, 118305 (2020). https://doi.org/10.1016/j.lfs.2020.118305

    Article  CAS  PubMed  Google Scholar 

  176. H. Gong, M. Gao, Y. Lin, J. Liu, Z. Hu, J. Liu, Oxid. Med. Cell Longev. 2022, 7843863 (2022). https://doi.org/10.1155/2022/7843863

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  177. R. Zhang, T. Pan, Y. Xiang, M. Zhang, H. Xie, Z. Liang, B. Chen, C. Xu, J. Wang, X. Huang, Q. Zhu, Z. Zhao, Q. Gao, C. Wen, W. Liu, W. Ma, J. Feng, X. Sun, T. Duan, E. Lai-Han Leung, T. Xie, Q. Wu, X. Sui, Bioact. Mater. 13, 23–36 (2022). https://doi.org/10.1016/j.bioactmat.2021.11.013

    Article  CAS  PubMed  Google Scholar 

  178. X. Qiu, Q. Shi, X. Zhang, X. Shi, H. Jiang, S. Qin, Mol. Cancer Res. 20, 1636–1645 (2022). https://doi.org/10.1158/1541-7786.mcr-22-0024

    Article  CAS  PubMed  Google Scholar 

  179. W. Luo, J. Wang, W. Xu, C. Ma, F. Wan, Y. Huang, M. Yao, H. Zhang, Y. Qu, D. Ye, Y. Zhu, Cell Death Dis. 12, 1043 (2021). https://doi.org/10.1038/s41419-021-04296-1

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  180. Y. Zhang, M. Luo, X. Cui, D. O’Connell, Y. Yang, Cell Death Differ. 29, 1850–1863 (2022). https://doi.org/10.1038/s41418-022-00970-9

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  181. X. Zhang, L. Wang, H. Li, L. Zhang, X. Zheng, W. Cheng, Cell Death Dis. 11, 580 (2020). https://doi.org/10.1038/s41419-020-02772-8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  182. H. Yang, Y. Hu, M. Weng, X. Liu, P. Wan, Y. Hu, M. Ma, Y. Zhang, H. Xia, K. Lv, J. Adv. Res. 37, 91–106 (2022). https://doi.org/10.1016/j.jare.2021.10.001

    Article  CAS  PubMed  Google Scholar 

  183. Y. Luo, S. Huang, J. Wei, H. Zhou, W. Wang, J. Yang, Q. Deng, H. Wang, Z. Fu, Clin. Transl. Med. 12, e752 (2022). https://doi.org/10.1002/ctm2.752

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  184. Z. Lin, J. Song, Y. Gao, S. Huang, R. Dou, P. Zhong, G. Huang, L. Han, J. Zheng, X. Zhang, S. Wang, B. Xiong, Redox Biol. 52, 102312 (2022). https://doi.org/10.1016/j.redox.2022.102312

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  185. G. Huang, Z. Xiang, H. Wu, Q. He, R. Dou, Z. Lin, C. Yang, S. Huang, J. Song, Z. Di, S. Wang, B. Xiong, Int. J. Biol. Sci. 18, 1415–1433 (2022). https://doi.org/10.7150/ijbs.69454

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  186. A.T. He, J. Liu, F. Li, B.B. Yang, Signal Transduct. Target Ther. 6, 185 (2021). https://doi.org/10.1038/s41392-021-00569-5

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  187. W.Y. Zhou, Z.R. Cai, J. Liu, D.S. Wang, H.Q. Ju, R.H. Xu, Mol. Cancer 19, 172 (2020). https://doi.org/10.1186/s12943-020-01286-3

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  188. X. Tang, H. Ren, M. Guo, J. Qian, Y. Yang, C. Gu, Comput. Struct. Biotechnol. J. 19, 910–928 (2021). https://doi.org/10.1016/j.csbj.2021.01.018

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  189. C.F. Pan, K. Wei, Z.J. Ma, Y.Z. He, J.J. Huang, Z.Z. Guo, Z.P. Chen, M.P. Barr, R.E. Shackelford, Y. Xia, J. Wang, Transl Lung Cancer Res 11, 366–380 (2022). https://doi.org/10.21037/tlcr-22-138

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  190. H.H. Wang, J.N. Ma, X.R. Zhan, Front. Endocrinol. (Lausanne) 12, 670031 (2021). https://doi.org/10.3389/fendo.2021.670031

    Article  PubMed  Google Scholar 

  191. Y. Liu, L. Li, Z. Yang, D. Wen, Z. Hu, J. Oncol. 2022, 5228874 (2022). https://doi.org/10.1155/2022/5228874

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  192. W. Yao, J. Wang, F. Meng, Z. Zhu, X. Jia, L. Xu, Q. Zhang, L. Wei, Front. Oncol. 11, 780938 (2021). https://doi.org/10.3389/fonc.2021.780938

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  193. W. Chen, J. Fu, Y. Chen, Y. Li, L. Ning, D. Huang, S. Yan, Q. Zhang, Aging (Albany NY) 13, 16500–16512 (2021). https://doi.org/10.18632/aging.203172

    Article  CAS  PubMed  Google Scholar 

  194. Z. Liu, Q. Wang, X. Wang, Z. Xu, X. Wei, J. Li, Cell Death Discov. 6, 72 (2020). https://doi.org/10.1038/s41420-020-00306-x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  195. J. Zhang, S. Chen, S. Wei, S. Cheng, R. Shi, R. Zhao, W. Zhang, Q. Zhang, T. Hua, D. Feng, Z. Yu, H. Wang, Redox Biol. 57, 102493 (2022). https://doi.org/10.1016/j.redox.2022.102493

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  196. X. Zhang, Y. Xu, L. Ma, K. Yu, Y. Niu, X. Xu, Y. Shi, S. Guo, X. Xue, Y. Wang, S. Qiu, J. Cui, H. Wang, X. Tian, Y. Miao, F. Meng, Y. Qiao, Y. Yu, J. Wang, Cancer Commun. (Lond) 42, 287–313 (2022). https://doi.org/10.1002/cac2.12275

    Article  PubMed  Google Scholar 

  197. Y. Wang, H. Chen, X. Wei, Eur. J. Clin. Invest. 51, e13541 (2021). https://doi.org/10.1111/eci.13541

    Article  CAS  PubMed  Google Scholar 

  198. S. Chen, Z. Zhang, B. Zhang, Q. Huang, Y. Liu, Y. Qiu, X. Long, M. Wu, Z. Zhang, Int. J. Biol. Sci. 18, 841–857 (2022). https://doi.org/10.7150/ijbs.66114

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  199. H.Y. Zhang, B.W. Zhang, Z.B. Zhang, Q.J. Deng, Eur. Rev. Med. Pharmacol. Sci. 24, 2585–2600 (2020). https://doi.org/10.26355/eurrev_202003_20528

    Article  PubMed  Google Scholar 

  200. H. Zhang, Z. Ge, Z. Wang, Y. Gao, Y. Wang, X. Qu, Aging (Albany NY) 13, 8115–8126 (2021). https://doi.org/10.18632/aging.202608

    Article  CAS  PubMed  Google Scholar 

  201. Y. Jiang, J. Zhao, R. Li, Y. Liu, L. Zhou, C. Wang, C. Lv, L. Gao, D. Cui, J. Exp. Clin. Cancer Res 41, 307 (2022). https://doi.org/10.1186/s13046-022-02518-8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  202. X. Yang, Y. Li, Y. Zhang, J. Liu, Hematology 27, 11–22 (2022). https://doi.org/10.1080/16078454.2021.2008590

    Article  CAS  PubMed  Google Scholar 

  203. Z.Y. Xian, B. Hu, T. Wang, J.L. Cai, J.Y. Zeng, Q. Zou, P.X. Zhu, Neoplasma 67, 1063–1073 (2020). https://doi.org/10.4149/neo_2020_191024N1084

    Article  CAS  PubMed  Google Scholar 

  204. Q. Babar, A. Saeed, T.A. Tabish, S. Pricl, H. Townley, N. Thorat, Biochim. Biophys. Acta Mol. Basis Dis. 1868, 166552 (2022). https://doi.org/10.1016/j.bbadis.2022.166552

    Article  CAS  PubMed  Google Scholar 

  205. S. Feng, D.D. De Carvalho, FEBS J 289, 1214–1239 (2022). https://doi.org/10.1111/febs.15750

    Article  CAS  PubMed  Google Scholar 

  206. H.C. Tsai, S.B. Baylin, Cell Res. 21, 502–517 (2011). https://doi.org/10.1038/cr.2011.24

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  207. H. Yang, L. Zhao, Y. Gao, F. Yao, T.M. Marti, R.A. Schmid, R.W. Peng, Cancers (Basel) 12, (2020). https://doi.org/10.3390/cancers12113273

  208. Y. Du, M. Han, K. Cao, Q. Li, J. Pang, L. Dou, S. Liu, Z. Shi, F. Yan, S. Feng, ACS Nano 15, 17689–17704 (2021). https://doi.org/10.1021/acsnano.1c05547

    Article  CAS  PubMed  Google Scholar 

  209. Y. Cheng, Y. Xie, Y. Chen, X. Liu, Oxid. Med. Cell Longev. 2021, 8854790 (2021). https://doi.org/10.1155/2021/8854790

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  210. C. Zhang, X. Liu, S. Jin, Y. Chen, R. Guo, Mol. Cancer 21, 47 (2022). https://doi.org/10.1186/s12943-022-01530-y

    Article  PubMed  PubMed Central  Google Scholar 

  211. X. Jiang, B.R. Stockwell, M. Conrad, Nat. Rev. Mol. Cell Biol. 22, 266–282 (2021). https://doi.org/10.1038/s41580-020-00324-8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  212. G. Lei, L. Zhuang, B. Gan, Nat. Rev. Cancer 22, 381–396 (2022). https://doi.org/10.1038/s41568-022-00459-0

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  213. C. Gorrini, I.S. Harris, T.W. Mak, Nat. Rev. Drug Discov. 12, 931–947 (2013). https://doi.org/10.1038/nrd4002

    Article  CAS  PubMed  Google Scholar 

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Funding

This study was supported by the National Research Foundation of Korea (NRF) grant, funded by the Ministry of Science and ICT (MSIT), Republic of Korea (No. 2019R1A2C2002259).

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Authors and Affiliations

  1. Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, 13496, Republic of Korea

    Jaewang Lee & Jong-Lyel Roh

  2. Department of Biomedical Science, General Graduate School, CHA University, Seongnam, Republic of Korea

    Jaewang Lee & Jong-Lyel Roh

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JL: Conceived the structure of the article and wrote the manuscript; JLR: Contributed to planning and manuscript writing, and acquired funding.

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Highlights

• Ferroptosis is a form of oxidative-regulated cell death caused by iron-mediated lipid peroxidation.

• Epigenetic modifications can regulate ferroptosis by altering gene expression or cell phenotype.

• Epigenetic mechanisms include DNA methylation, histone modifications, RNA modifications, and noncoding RNAs.

• Epigenetic modifications can affect cell sensitivity to ferroptosis inducers.

• Targeting epigenetic alterations is a promising approach to tackling cancer resilience.

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Lee, J., Roh, JL. Epigenetic modulation of ferroptosis in cancer: Identifying epigenetic targets for novel anticancer therapy. Cell Oncol. 46, 1605–1623 (2023). https://doi.org/10.1007/s13402-023-00840-7

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