Abstract
Ferroptosis is a regulated form of cell death characterized by iron-catalyzed and reactive oxygen species (ROS)-mediated lipid peroxidation. It plays a crucial role in tumorigenesis, tumor progression, and cancer therapy. Epigenetic regulation has emerged as a promising target for cancer treatment, but the regulatory mechanisms involved in ferroptosis are complex and diverse. In this chapter, we provide a comprehensive summary of the key mechanisms and regulators that are primarily associated with iron metabolism, ROS signaling, and lipid metabolism in ferroptosis. Additionally, we delve into the epigenetic aspects of ferroptosis regulation, including chromatin remodeling, DNA methylation, histone modifications, and non-coding RNAs, and their impact on ferroptosis-related factors. Furthermore, we highlight the growing interest in utilizing epigenetic drugs to target ferroptosis as a therapeutic strategy in cancer treatment. We emphasize the significance of understanding the role of epigenetic regulation in ferroptosis, as it holds the potential to enhance the effectiveness of cancer therapy by combining epigenetic inhibition with ferroptosis induction.
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Wang, Z., Tao, T., Tao, Y. (2023). Targeting Epigenetic Regulation of Ferroptosis in Cancer Therapy. In: Tang, D. (eds) Ferroptosis in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-031-39171-2_3
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