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MiRNAs-mediated cisplatin resistance in breast cancer

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Tumor Biology

Abstract

Cisplatin is a widely used chemotherapeutic agent in breast cancer treatments with inevitable rapidly acquired resistance or intrinsically resistance. Enormous evidence points to the bioprocesses of resistant formation consisting of diverse miRNAs direct and indirect actions on relevant encoding genes. In this report, we overview detailed information on the miRNAs effect on cisplatin-induced resistance, including alterations in cell survival, modification of DNA damage response, changes in cellular uptake or efflux of the drug, altered DNA methylation, and perturbations in the miRNA biogenesis pathway. This will provide potential miRNA-targeted strategies for the treatment of breast cancer therapy and requires further clinical application.

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Acknowledgments

This study was funded by the National Natural Science Foundation of China (grant number 81272470). We thank Shan-liang Zhong for his help in revision of the present paper.

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Authors and Affiliations

  1. The Fourth Clinical School of Nanjing Medical University, Baiziting42, Nanjing, China

    Xiu Chen, Su-jin Yang & Hong-Yu Shen

  2. Department of General Surgery, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University and First Affiliated Hospital of Nanjing Medical University, 210009, Baiziting42, Nanjing, China

    Xiu Chen, Dan-dan Wang, Siying Zhou, Su-jin Yang, Hong-Yu Shen & Jin-hai Tang

  3. School of Public Health Nanjing Medical University, Longmiandadao101, Nanjing, China

    Peng Lu

  4. The First Clinical School of Nanjing Medical University, Baiziting42, Nanjing, China

    Ying Wu

  5. Center of Clinical Laboratory Science, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Baiziting42, Nanjing, China

    Xiao-hui Zhang & Jian-hua Zhao

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  1. Xiu Chen
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  6. Su-jin Yang
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  7. Hong-Yu Shen
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  10. Jin-hai Tang
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Correspondence to Jin-hai Tang.

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Xiu Chen and Peng Lu contributed equally to this work.

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Chen, X., Lu, P., Wu, Y. et al. MiRNAs-mediated cisplatin resistance in breast cancer. Tumor Biol. 37, 12905–12913 (2016). https://doi.org/10.1007/s13277-016-5216-6

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  • DOI: https://doi.org/10.1007/s13277-016-5216-6

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