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PDGF: the nuts and bolts of signalling toolbox

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Tumor Biology

Abstract

PDGF is a growth factor and is extensively involved in multi-dimensional cellular dynamics. It switches on a plethora of molecules other than its classical pathway. It is engaged in various transitions of development; however, if the unleashed potentials lead astray, it brings forth tumourigenesis. Conventionally, it has been assumed that the components of this signalling pathway show fidelity and act with a high degree of autonomy. However, as illustrated by the PDGF signal transduction, reinterpretation of recent data suggests that machinery is often shared between multiple pathways, and other components crosstalk to each other through multiple mechanisms. It is important to note that metastatic cascade is an intricate process that we have only begun to understand in recent years. Many of the early steps of this PDGF cascade are not readily targetable in the clinic. In this review, we will unravel the paradoxes with reference to mitrons and cellular plasticity and discuss how disruption of signalling cascade triggers cellular proliferation phase transition and metastasis. We will also focus on the therapeutic interventions to counteract resultant molecular disorders.

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Authors and Affiliations

  1. Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, 1 km defence road, Lahore, Pakistan

    Ammad Ahmad Farooqi, Salman Waseem, Asma M. Riaz, Bilal Ahmed Dilawar, Shahzeray Mukhtar, Sehrish Minhaj, Makhdoom Saad Waseem, Suneel Daniel, Beenish Ali Malik, Ali Nawaz & Shahzad Bhatti

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  1. Ammad Ahmad Farooqi
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  2. Salman Waseem
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Correspondence to Ammad Ahmad Farooqi or Shahzad Bhatti.

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Farooqi, A.A., Waseem, S., Riaz, A.M. et al. PDGF: the nuts and bolts of signalling toolbox. Tumor Biol. 32, 1057–1070 (2011). https://doi.org/10.1007/s13277-011-0212-3

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  • DOI: https://doi.org/10.1007/s13277-011-0212-3

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