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Poly(ε-caprolactone)/gelatin nanofibrous scaffolds for wound dressing

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Abstract

Porous poly(ε-caprolactone)/gelatin (P/g) scaffolds were electrospun at 18 wt% polymer concentration using a common solvent of diluted acetic acid and ethyl acetate to evaluate the effect of P/g weight ratio in the range of 9/1–5/5 on mechanical properties, porosity, moisture vapor transmission rate (MVTR), and biocompatibility of scaffolds. The precursor solution exhibited a gelatin concentration-dependent decrease in viscosity and increase in conductivity in the range of P/g ratios from 9/1 to 5/5 in the scaffolds. Fourier transform infrared spectroscopy (FT-IR) results showed an interaction of hydrogen (H) bond between the ester group (–COO) of PCL and the amine group (–NH2) of gelatin molecule in the P/g scaffold. The highest water uptake capacity (541%) and MVTR values (1522.3 ± 13.48 g/m2·24 h) were observed on the 7/3 P/g scaffold. The highest strength of 4.8 ± 0.6 MPa was observed on the 6/4 scaffold. The P/g scaffolds showed no evidence of causing cell lysis or toxicity. Among the scaffolds, 7/3 and 6/4 P/g scaffolds appeared to be suitable as wound dressings due to their excellent MVTR, water uptake capacity, cell viability, proliferation, attachment and mechanical strength.

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Acknowledgements

This work was supported by the Materials & Components Technology Development Program (Project No. 20003560), funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea).

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Ministry of Trade, Industry and Energy, 20003560, Deuk Yong Lee.

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Authors and Affiliations

  1. Department of Materials Science and Engineering, Korea Aerospace University, Goyang, 10540, Korea

    Yo-Seung Song

  2. Department of Materials Science and Engineering, Incheon National University, Incheon, 22012, Korea

    Bae-Yeon Kim

  3. Institute of Cell and Tissue Engineering, College of Medicine, The Catholic University of Korea, Seoul, 06591, Korea

    Dae Hyeok Yang

  4. Department of Biomedical Engineering, Daelim University, Anyang, 13916, Korea

    Deuk Yong Lee

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  1. Yo-Seung Song
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  2. Bae-Yeon Kim
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Correspondence to Deuk Yong Lee.

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Song, YS., Kim, BY., Yang, D.H. et al. Poly(ε-caprolactone)/gelatin nanofibrous scaffolds for wound dressing. Appl Nanosci 12, 3261–3270 (2022). https://doi.org/10.1007/s13204-021-02265-w

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  • DOI: https://doi.org/10.1007/s13204-021-02265-w

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