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Mechanical properties and cytotoxicity of PLA/PCL films

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Abstract

Thermodynamically immiscible poly(lactic acid) (PLA) and poly(ε-caprolactone) (PCL) were blended and solution-cast by adding the 3% compatibilizer (tributyl citrate, TBC) of the PCL weight. In the PLA/PCL composition range of 99/1–95/5 wt%, mechanical properties of the PLA/PCL films with TBC were always superior to those of the films without TBC. The tensile strength of 42.9 ± 3.5 MPa and the elongation at break of 10.3 ± 2.7% were observed for the 93/7 PLA/PCL films without TBC, indicating that PCL addition is effective for strength and ductility. However, the tensile strength of 54.1 ± 3.4 MPa and the elongation at break of 8.8 ± 1.8% were found for the 95/5 PLA/PCL with TBC, indicating that the effect of co-addition of PCL and TBC on mechanical properties of the films is more pronounced. No cytotoxicity was observed for the PLA/PCL films regardless of TBC addition.

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Acknowledgements

KJK and TH would like to acknowledge this material is based upon work supported in part by the National Science Foundation under Grant No. IIA-1301726.

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Authors and Affiliations

  1. Convergence Institute of Biomedical Engineering and Biomaterials, Seoul National University of Science and Technology, Seoul, 01811, Korea

    Heeseok Jeong

  2. Department of Biomedical Engineering, Daelim University, Anyang, 13916, Korea

    Jeongwon Rho, Ji-Yeon Shin & Deuk Yong Lee

  3. Department of Mechanical Engineering, University of Nevada, Las Vegas, NV, 89154, USA

    Taeseon Hwang & Kwang J. Kim

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  1. Heeseok Jeong
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  2. Jeongwon Rho
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  3. Ji-Yeon Shin
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  4. Deuk Yong Lee
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Correspondence to Deuk Yong Lee.

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Jeong, H., Rho, J., Shin, JY. et al. Mechanical properties and cytotoxicity of PLA/PCL films. Biomed. Eng. Lett. 8, 267–272 (2018). https://doi.org/10.1007/s13534-018-0065-4

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  • DOI: https://doi.org/10.1007/s13534-018-0065-4

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