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MicroRNA-126 (MiR-126): key roles in related diseases

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Abstract

In eukaryotes such as humans, some non-coding single-stranded RNAs (ncRNAs) help to regulate the pre- and post-transcriptional expression of certain genes, which in turn control many important physiological processes, such as cell proliferation, distinctions, invasion, angiogenesis, and embryonic development. microRNA-126 is an important member of these miRNAs that can be directly or indirectly involved in the control of angiogenesis. Recently, numerous studies have expounded that microRNA-126 can inhibit or promote angiogenesis as well as attenuate inflammatory responses through complex molecular mechanisms. As such, it serves as a biomarker or potential therapeutic target for the prediction, diagnosis, and treatment of relevant diseases. In this review, we present the advancements in research regarding microRNA-126’s role in the diagnosis and treatment of related diseases, aiming to provide innovative therapeutic options for the diagnosis and treatment of clinically relevant diseases.

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Acknowledgements

Dear Editor, The “potential human face” detected by the initial technical check in the manuscript is hand-drawn portrait and is not real human beings. Therefore, no personal likeness or privacy rights are involved. I understand and accept that the image may be used for academic and educational purposes and published in your journal. Please feel free to contact me if there are any further questions or requests. Best wishes. Sincerely yours, Liao Li, et al. 4th, December, 2023

Funding

The study was supported by the Chengdu Medical Research Project (NO.2022655), the Sichuan Provincial Medical Youth Innovation Research Project (NO.Q20027), and the Sichuan Hospital Association Young Pharmacist Research Special Fund Project (NO.22047).

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Authors and Affiliations

  1. The Second People’s Hospital of Yibin-Yibin Hospital of West China Hospital of Sichuan University, Yibin, 644000, China

    Li Liao, Yan Tang, Yanping Zhou, Xianglin Meng & Xiaochun Zhang

  2. Third Affiliated Hospital of Chengdu Medical College-Chengdu Pidu District People’s Hospital, Chengdu, 611700, China

    Bo Li

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  1. Li Liao
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Li Liao and Xiaochun Zhang conceived and designed the manuscript. Li Liao wrote the manuscript. Yan Tang, Yanping Zhou, Xianglin Meng and Bo Li participated in revising and drawing the manuscript. Yan Tang and Xiaochun Zhang provided critical revision of the manuscript for important intellectual content and language editing. All the authors read and approved the final manuscript.

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Liao, L., Tang, Y., Zhou, Y. et al. MicroRNA-126 (MiR-126): key roles in related diseases. J Physiol Biochem (2024). https://doi.org/10.1007/s13105-024-01017-y

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