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Targets and regulation of microRNA-652-3p in homoeostasis and disease

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Abstract

microRNA are small non-coding RNA molecules which inhibit gene expression by binding mRNA, preventing its translation. As important regulators of gene expression, there is increasing interest in microRNAs as potential diagnostic biomarkers and therapeutic targets. Studies investigating the role of one of the miRNA—miR-652-3p—detail diverse roles for this miRNA in normal cell homoeostasis and disease states, including cancers, cardiovascular disease, mental health, and central nervous system diseases. Here, we review recent literature surrounding miR-652-3p, discussing its known target genes and their relevance to disease progression. These studies demonstrate that miR-652-3p targets LLGL1 and ZEB1 to modulate cell polarity mechanisms, with impacts on cancer metastasis and asymmetric cell division. Inhibition of the NOTCH ligand JAG1 by miR-652-3p can have diverse effects on angiogenesis and immune cell regulation. Investigation of miR-652-3p and other dysregulated miRNAs identified a number of pathways potentially regulated by miR-652-3p. This review demonstrates that miR-652-3p has great promise as a diagnostic or therapeutic target due to its activity across multiple cellular systems.

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MS was a recipient of a UTS Research Excellence Scholarship.

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  1. School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia

    Maxwell T. Stevens & Bernadette M. Saunders

  2. Centenary Institute, The University of Sydney, Sydney, NSW, Australia

    Bernadette M. Saunders

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MS performed the literature search and data analysis and wrote the manuscript; BS supervised and reviewed the work. All authors have read and approved this final version of the review.

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Stevens, M.T., Saunders, B.M. Targets and regulation of microRNA-652-3p in homoeostasis and disease. J Mol Med 99, 755–769 (2021). https://doi.org/10.1007/s00109-021-02060-8

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