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RETRACTED ARTICLE: MicroRNA-126 inhibits osteosarcoma cells proliferation by targeting Sirt1

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Tumor Biology

This article was retracted on 20 April 2017

Abstract

Numerous studies have recently suggested that miRNAs contribute to the development of various types of human cancer as well as to their proliferation and metastasis. The aim of this study was to investigate the functional significance of miR-126 and to identify its possible target genes in osteosarcoma (OS) cells. Here, we found that expression level of miR-126 was reduced in osteosarcoma cells in comparison with the adjacent normal tissues. The enforced expression of miR-126 was able to inhibit cell proliferation in U2OS and MG62 cells, while miR-126 antisense oligonucleotides (antisense miR-126) promoted cell proliferation. At the molecular level, our results further revealed that expression of Sirt1, a member of histone deacetylase, was negatively regulated by miR-126. Therefore, the data reported here demonstrate that miR-126 is an important regulator in osteosarcoma, which will contribute to better understanding of the important misregulated miRNAs in osteosarcoma cells.

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Acknowledgments

This work was supported by The National Natural Science Foundation of China (81072188).

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Authors and Affiliations

  1. Department of Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine No.197, Ruijin 2nd Road, Shanghai, China, 200025

    Jian-Qiang Xu

  2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China

    Ping Liu

  3. Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine No.197, Ruijin 2nd Road, Shanghai, China, 200025

    Ming-Jue Si & Xiao-Yi Ding

Authors
  1. Jian-Qiang Xu
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  2. Ping Liu
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  4. Xiao-Yi Ding
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Corresponding author

Correspondence to Xiao-Yi Ding.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article can be found online at http://dx.doi.org/10.1007/s13277-017-5487-6.

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Xu, JQ., Liu, P., Si, MJ. et al. RETRACTED ARTICLE: MicroRNA-126 inhibits osteosarcoma cells proliferation by targeting Sirt1. Tumor Biol. 34, 3871–3877 (2013). https://doi.org/10.1007/s13277-013-0974-x

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  • DOI: https://doi.org/10.1007/s13277-013-0974-x

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