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Immunomodulation by Exosomes in Myocardial Infarction

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Abstract

Exosomes are important carriers of biological information that facilitate intercellular communication and participate in the pathophysiology of different cardiovascular diseases. Myocardial infarction is among the leading causes of death worldwide. Upon myocardial infarction, massive cardiomyocyte death triggers a strong inflammatory response which is a vital process of cardiac injury, repair, and remodeling. Increasing evidence has unveiled that exosomes are involved in the inflammatory response and immune regulation after myocardial infarction. In this review, we will summarize the biological function of exosomes in the pathophysiology of myocardial infarction, especially focusing on their roles in the modulation of inflammation and immune response after myocardial infarction which further influences myocardial repair and remodeling. We will also discuss the immunomodulation by exosomes derived from stem and progenitor cells in the treatment of myocardial infarction. A deep understanding of immunomodulation by exosomes may represent a promising therapeutic option for the treatment of myocardial infarction.

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Funding

This work was supported by the grants from National Natural Science Foundation of China (81770401 to Y.B.) and National Key Research and Development Program of China (2017YFC1700401 to Y.B.)

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Authors and Affiliations

  1. Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China

    Wen Pan, Yujiao Zhu, Xiangmin Meng & Yihua Bei

  2. Shanghai Key Laboratory of Bio-Energy Crops, School of Life Sciences, Shanghai University, Shanghai, 200444, China

    Yujiao Zhu

  3. Department of Anesthesiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200082, China

    Chenlin Zhang

  4. Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, China

    Yan Yang

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  1. Wen Pan
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  3. Xiangmin Meng
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  4. Chenlin Zhang
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  5. Yan Yang
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Correspondence to Yan Yang or Yihua Bei.

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Pan, W., Zhu, Y., Meng, X. et al. Immunomodulation by Exosomes in Myocardial Infarction. J. of Cardiovasc. Trans. Res. 12, 28–36 (2019). https://doi.org/10.1007/s12265-018-9836-7

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