Abstract
Bifidobacteria as a strictly anaerobic gram-positive bacteria, is widely distributed in the intestine, vagina and oral cavity, and is one of the first gut flora to colonize the early stages of life. Intestinal flora is closely related to health, and dysbiosis of intestinal flora, especially Bifidobacteria, has been found in a variety of diseases. Numerous studies have shown that in addition to maintaining intestinal homeostasis, Bifidobacteria may be involved in diseases covering all parts of the body, including the nervous system, respiratory system, genitourinary system and so on. This review collects evidence for the variation of Bifidobacteria in typical diseases among various systems, provides mild and effective therapeutic options for those diseases that are difficult to cure, and moves Bifidobacteria from basic research to further clinical applications.
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Acknowledgements
This work was supported by the Health Commission of Shandong Province (202012010629, 202112010222, M-20222055), Ji’nan Science and Technology Bureau (202019108), National Natural Science Foundation of China (81573198; 30901214), the Innovation Project of Shandong Academy of Medical Sciences, Academic Promotion Programme of Shandong First Medical University (2019QL001), Ministry of Science and Technology of PRC (2018ZX09711001–011). I have to thank Mr. Cui for his support and encouragement in both material and spiritual aspects, which made my every day full of sunshine. And thanks to Ms. Guo and Professor Sun of Shanxi Agricultural University for their kindness, which gave me great courage to go on when I am confused and lost.
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All authors contributed to the study conception and design. Original draft writing was performed by Weiliang Zhang and Linlin Sai; manuscript editing was performed by Xin Zhang, Ru Han, Shichao Sun and Mingming Han; manuscript reviewing was performed by Cunxiang Bo, Qiang Jia, Wenhui Yin and Limin Guo. All authors have read and approved to the published version of the manuscript.
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Zhang, W., Jia, Q., Han, M. et al. Bifidobacteria in disease: from head to toe. Folia Microbiol 69, 1–15 (2024). https://doi.org/10.1007/s12223-023-01087-3
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DOI: https://doi.org/10.1007/s12223-023-01087-3