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The effect of tropisetron on peripheral diabetic neuropathy: possible protective actions against inflammation and apoptosis

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Cell Stress and Chaperones Aims and scope

Abstract

Diabetic peripheral neuropathy (DPN) is a common nerve disorder of diabetes. The aim of this study was to explore the protective effects of tropisetron in DPN. Type 1 diabetes was created by a single injection of streptozotocin (50 mg/kg, ip). Tropisetron (3 mg/kg, ip) was administered daily for 2 weeks. Our analysis showed that nerve fibers and their myelin sheaths were thinned with decreased myelinated fiber number in diabetic animals. The intensity of Bcl-2 staining decreased and the intensity of Bax staining increased in the sciatic nerves of diabetic rats by using immunohistochemical staining. Furthermore, diabetes significantly increased tumor necrosis factor-alpha, interleukin 1-β (TNFα and IL-1β) and Bax/Bcl-2 ratio in sciatic nerves of rats. However, intraperitoneal injection of tropisetron significantly reversed these alterations induced by diabetes. These findings suggest that tropisetron attenuates diabetes-induced peripheral nerve injury through its anti-inflammatory and anti-apoptotic effects, and may provide a novel therapeutic strategy to ameliorate the process of peripheral neuropathy in diabetes.

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Acknowledgements

We are thankful to the Urmia University of Medical Sciences for supporting this project.

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Authors and Affiliations

  1. Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran

    Amir Mohammad Ghazipour

  2. Neurophysiology Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran

    Bagher Pourheydar & Roya Naderi

  3. Department of Anatomical Sciences, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran

    Bagher Pourheydar

  4. Department of Physiology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran

    Roya Naderi

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  1. Amir Mohammad Ghazipour
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Correspondence to Roya Naderi.

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Ghazipour, A.M., Pourheydar, B. & Naderi, R. The effect of tropisetron on peripheral diabetic neuropathy: possible protective actions against inflammation and apoptosis. Cell Stress and Chaperones 27, 513–521 (2022). https://doi.org/10.1007/s12192-022-01287-9

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