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Prognostic value of geriatric nutritional risk index in patients with diffuse large B-cell lymphoma: a meta-analysis

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Abstract

Background

Geriatric nutritional risk index (GNRI) on the prognosis of patients with diffuse large B-cell lymphoma (DLBCL) remains unclear. The purpose of this meta-analysis was to discuss the value of the GNRI in evaluating long-term outcomes in DLBCL.

Methods

We systematically and roundly retrieved PubMed, Cochrane Library, Embase, Scopus and Web of Science electronic databases from inception of the databases to March 20, 2023. At the same time, we calculated the pool hazard ratios (HRs) with their 95% confidence interval (CI) for overall survival and progression-free survival to assess the effect of GNRI on the prognosis of DLBCL patients.

Results

In our primary meta-analysis, 7 trials with a total of 2448 patients were enrolled. Results showed that lower level of GNRI was related to poorer overall survival (HR = 1.78, 95% CI 1.27, 2.50, p < 0.01) and worse progression-free survival (HR = 2.31, 95% CI 1.71, 3.13, p < 0.01) in DLBCL patients.

Conclusion

The results of our meta-analysis indicate that a lower GNRI significantly associated with poorer prognosis for DLBCL. It is believed that GNRI was a promisingly predictive indicator of survival outcomes in DLBCL patients. However, large multicenter prospective studies are necessary to verify the results.

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Acknowledgements

We thank all researchers and study participants for their contributions.

Funding

Key R&D Projects, Jiangxi (20181BBG70022).

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Authors and Affiliations

  1. The Second Affiliated Hospital of Nanchang University, 1 Min De Road, Nanchang, 330006, Jiangxi, China

    Chengkun Yan, Yanyou Xie, Yaqi Hua & Jiehua Wu

  2. School of Nursing, Nanchang University, 461 Ba Yi Road, Nanchang, 330006, Jiangxi, China

    Chengkun Yan, Yaqi Hua, Huanxu Fu & Zhiqiang Cheng

  3. Red Flag Hospital Affiliated to Mudanjiang Medical College, 5 Tong Xiang Road, Mudanjiang, 157011, Heilongjiang, China

    Sihui Li

  4. The First Affiliated Hospital of Nanchang University, 17, Yong Wai Zheng Road, Nanchang, 330006, Jiangxi, China

    Huanxu Fu & Zhiqiang Cheng

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  1. Chengkun Yan
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Contributions

The final manuscript was read, reviewed, and approved by all authors. CY and YX: study concept and design; literature search and acquisition of data; data analysis; preparation of manuscript. YH and SL: literature search; critical revision before submission. HF and ZC: revision of the manuscript. JW: study concept and design; critical revision of the manuscript; final approval of the version to be published.

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Correspondence to Jiehua Wu.

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Yan, C., Xie, Y., Hua, Y. et al. Prognostic value of geriatric nutritional risk index in patients with diffuse large B-cell lymphoma: a meta-analysis. Clin Transl Oncol 26, 515–523 (2024). https://doi.org/10.1007/s12094-023-03271-w

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  • DOI: https://doi.org/10.1007/s12094-023-03271-w

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