Skip to main content

Advertisement

SpringerLink
Log in

Geriatric nutritional risk index as a prognostic factor in patients with diffuse large B cell lymphoma

  • Original Article
  • Published:
Annals of Hematology Aims and scope Submit manuscript

Abstract

The geriatric nutritional risk index (GNRI) is a simple and well-established nutritional assessment tool that is a significant prognostic factor for various cancers. However, the role of the GNRI in predicting clinical outcomes of diffuse large B cell lymphoma (DLBCL) patients has not been investigated. To address this issue, we retrospectively analyzed a total of 476 patients with newly diagnosed de novo DLBCL. We defined the best cutoff value of the GNRI as 96.8 using a receiver operating characteristic curve. Patients with a GNRI < 96.8 had significantly lower overall survival (OS) and progression-free survival (PFS) than those with a GNRI ≥ 96.8 (5-year OS, 61.2 vs. 84.4%, P < 0.001; 5-year PFS, 53.7 vs. 75.8%, P < 0.001). Multivariate analysis showed that performance status, Ann Arbor stage, serum lactate dehydrogenase, and GNRI were independent prognostic factors for OS. Among patients with high-intermediate and high-risk by National Comprehensive Cancer Network-International Prognostic Index (NCCN-IPI), the 5-year OS was significantly lower in patients with a GNRI < 96.8 than in those with a GNRI ≥ 96.8 (high-intermediate risk, 59.5 vs. 75.2%, P = 0.006; high risk, 37.4 vs. 64.9%, P = 0.033). In the present study, we demonstrated that the GNRI was an independent prognostic factor in DLBCL patients. The GNRI could identify a population of poor-risk patients among those with high-intermediate and high-risk by NCCN-IPI.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (2008) World Health Organization classification of tumours of haematopoietic and lymphoid tissues, 4th edn. France IARC Press, Lyon, pp 233–237

    Google Scholar 

  2. Coiffier B, Lepage E, Briere J, Herbrecht R, Tilly H, Bouabdallah R, Morel P, Van Den Neste E, Salles G, Gaulard P, Reyes F, Lederlin P, Gisselbrecht C (2002) CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med 346(4):235–242. https://doi.org/10.1056/NEJMoa011795

    Article  CAS  PubMed  Google Scholar 

  3. Habermann TM, Weller EA, Morrison VA, Gascoyne RD, Cassileth PA, Cohn JB, Dakhil SR, Woda B, Fisher RI, Peterson BA, Horning SJ (2006) Rituximab-CHOP versus CHOP alone or with maintenance rituximab in older patients with diffuse large B-cell lymphoma. J Clin Oncol Off J Am Soc Clin Oncol 24(19):3121–3127. https://doi.org/10.1200/jco.2005.05.1003

    Article  CAS  Google Scholar 

  4. Pfreundschuh M, Kuhnt E, Trumper L, Osterborg A, Trneny M, Shepherd L, Gill DS, Walewski J, Pettengell R, Jaeger U, Zinzani PL, Shpilberg O, Kvaloy S, de Nully Brown P, Stahel R, Milpied N, Lopez-Guillermo A, Poeschel V, Grass S, Loeffler M, Murawski N (2011) CHOP-like chemotherapy with or without rituximab in young patients with good-prognosis diffuse large-B-cell lymphoma: 6-year results of an open-label randomised study of the MabThera International Trial (MInT) Group. Lancet Oncol 12(11):1013–1022. https://doi.org/10.1016/s1470-2045(11)70235-2

    Article  CAS  PubMed  Google Scholar 

  5. Pfreundschuh M, Schubert J, Ziepert M, Schmits R, Mohren M, Lengfelder E, Reiser M, Nickenig C, Clemens M, Peter N, Bokemeyer C, Eimermacher H, Ho A, Hoffmann M, Mertelsmann R, Trumper L, Balleisen L, Liersch R, Metzner B, Hartmann F, Glass B, Poeschel V, Schmitz N, Ruebe C, Feller AC, Loeffler M (2008) Six versus eight cycles of bi-weekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20+ B-cell lymphomas: a randomised controlled trial (RICOVER-60). Lancet Oncol 9(2):105–116. https://doi.org/10.1016/s1470-2045(08)70002-0

    Article  CAS  PubMed  Google Scholar 

  6. Cortelazzo S, Tarella C, Gianni AM, Ladetto M, Barbui AM, Rossi A, Gritti G, Corradini P, Di Nicola M, Patti C, Mule A, Zanni M, Zoli V, Billio A, Piccin A, Negri G, Castellino C, Di Raimondo F, Ferreri AJ, Benedetti F, La Nasa G, Gini G, Trentin L, Frezzato M, Flenghi L, Falorio S, Chilosi M, Bruna R, Tabanelli V, Pileri S, Masciulli A, Delaini F, Boschini C, Rambaldi A (2016) Randomized trial comparing R-CHOP versus high-dose sequential chemotherapy in high-risk patients with diffuse large B-cell lymphomas. J Clin Oncol 34(33):4015–4022. https://doi.org/10.1200/jco.2016.67.2980

    Article  CAS  PubMed  Google Scholar 

  7. Friedberg JW (2011) Relapsed/refractory diffuse large B-cell lymphoma. Hematol Am Soc Hematol Educ Program 2011(1):498–505. https://doi.org/10.1182/asheducation-2011.1.498

    Google Scholar 

  8. The International Non-Hodgkin's Lymphoma Prognostic Factors Project (1993) A predictive model for aggressive non-Hodgkin’s lymphoma. N Engl J Med 329(14):987–994. https://doi.org/10.1056/nejm199309303291402

    Article  Google Scholar 

  9. Sehn LH, Berry B, Chhanabhai M, Fitzgerald C, Gill K, Hoskins P, Klasa R, Savage KJ, Shenkier T, Sutherland J, Gascoyne RD, Connors JM (2007) The revised International Prognostic Index (R-IPI) is a better predictor of outcome than the standard IPI for patients with diffuse large B-cell lymphoma treated with R-CHOP. Blood 109(5):1857–1861. https://doi.org/10.1182/blood-2006-08-038257

    Article  CAS  PubMed  Google Scholar 

  10. Zhou Z, Sehn LH, Rademaker AW, Gordon LI, Lacasce AS, Crosby-Thompson A, Vanderplas A, Zelenetz AD, Abel GA, Rodriguez MA, Nademanee A, Kaminski MS, Czuczman MS, Millenson M, Niland J, Gascoyne RD, Connors JM, Friedberg JW, Winter JN (2014) An enhanced International Prognostic Index (NCCN-IPI) for patients with diffuse large B-cell lymphoma treated in the rituximab era. Blood 123(6):837–842. https://doi.org/10.1182/blood-2013-09-524108

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Hao X, Wei Y, Wei X, Zhou L, Wei Q, Zhang Y, Huang W, Feng R (2017) Glasgow prognostic score is superior to other inflammation-based scores in predicting survival of diffuse large B-cell lymphoma. Oncotarget 8(44):76740–76748. https://doi.org/10.18632/oncotarget.20832

    Article  PubMed  PubMed Central  Google Scholar 

  12. Kim Y, Kim SJ, Hwang D, Jang J, Hyun SY, Kim YR, Kim JS, Min YH, Cheong JW (2014) The modified Glasgow Prognostic Scores as a predictor in diffuse large B cell lymphoma treated with R-CHOP regimen. Yonsei Med J 55(6):1568–1575. https://doi.org/10.3349/ymj.2014.55.6.1568

    Article  PubMed  PubMed Central  Google Scholar 

  13. Li X, Zhang Y, Zhao W, Liu Z, Shen Y, Li J, Shen Z (2015) The Glasgow Prognostic Score as a significant predictor of diffuse large B cell lymphoma treated with R-CHOP in China. Ann Hematol 94(1):57–63. https://doi.org/10.1007/s00277-014-2167-0

    Article  CAS  PubMed  Google Scholar 

  14. Perisa V, Zibar L, Knezovic A, Perisa I, Sincic-Petricevic J, Aurer I (2017) Prognostic nutritional index as a predictor of prognosis in patients with diffuse large B cell lymphoma. Wien Klin Wochenschr 129(11–12):411–419. https://doi.org/10.1007/s00508-016-1077-7

    Article  CAS  PubMed  Google Scholar 

  15. Zhou Q, Wei Y, Huang F, Wei X, Wei Q, Hao X, Zhang Y, Feng R (2016) Low prognostic nutritional index predicts poor outcome in diffuse large B-cell lymphoma treated with R-CHOP. Int J Hematol 104(4):485–490. https://doi.org/10.1007/s12185-016-2052-9

    Article  CAS  PubMed  Google Scholar 

  16. Park S, Han B, Cho JW, Woo SY, Kim S, Kim SJ, Kim WS (2014) Effect of nutritional status on survival outcome of diffuse large B-cell lymphoma patients treated with rituximab-CHOP. Nutr Cancer 66(2):225–233. https://doi.org/10.1080/01635581.2014.867065

    Article  CAS  PubMed  Google Scholar 

  17. Buzby GP, Knox LS, Crosby LO, Eisenberg JM, Haakenson CM, McNeal GE, Page CP, Peterson OL, Reinhardt GF, Williford WO (1988) Study protocol: a randomized clinical trial of total parenteral nutrition in malnourished surgical patients. Am J Clin Nutr 47(2 Suppl):366–381. https://doi.org/10.1093/ajcn/47.2.366

    Article  CAS  PubMed  Google Scholar 

  18. Buzby GP, Williford WO, Peterson OL, Crosby LO, Page CP, Reinhardt GF, Mullen JL (1988) A randomized clinical trial of total parenteral nutrition in malnourished surgical patients: the rationale and impact of previous clinical trials and pilot study on protocol design. Am J Clin Nutr 47(2 Suppl):357–365. https://doi.org/10.1093/ajcn/47.2.357

    Article  CAS  PubMed  Google Scholar 

  19. Naber TH, de Bree A, Schermer TR, Bakkeren J, Bar B, de Wild G, Katan MB (1997) Specificity of indexes of malnutrition when applied to apparently healthy people: the effect of age. Am J Clin Nutr 65(6):1721–1725. https://doi.org/10.1093/ajcn/65.6.1721

    Article  CAS  PubMed  Google Scholar 

  20. Bouillanne O, Morineau G, Dupont C, Coulombel I, Vincent JP, Nicolis I, Benazeth S, Cynober L, Aussel C (2005) Geriatric Nutritional Risk Index: a new index for evaluating at-risk elderly medical patients. Am J Clin Nutr 82(4):777–783

    Article  CAS  PubMed  Google Scholar 

  21. Bo Y, Wang K, Liu Y, You J, Cui H, Zhu Y, Lu Q, Yuan L (2016) The geriatric nutritional risk index predicts survival in elderly esophageal squamous cell carcinoma patients with radiotherapy. PLoS One 11(5):e0155903. https://doi.org/10.1371/journal.pone.0155903

    Article  PubMed  PubMed Central  Google Scholar 

  22. Gu W, Zhang G, Sun L, Ma Q, Cheng Y, Zhang H, Shi G, Zhu Y, Ye D (2015) Nutritional screening is strongly associated with overall survival in patients treated with targeted agents for metastatic renal cell carcinoma. J Cachexia Sarcopenia Muscle 6(3):222–230. https://doi.org/10.1002/jcsm.12025

    Article  PubMed  PubMed Central  Google Scholar 

  23. Miyake H, Tei H, Fujisawa M (2017) Geriatric nutrition risk index is an important predictor of cancer-specific survival, but not recurrence-free survival, in patients undergoing surgical resection for non-metastatic renal cell carcinoma. Curr Urol 10(1):26–31. https://doi.org/10.1159/000447147

    Article  PubMed  PubMed Central  Google Scholar 

  24. Shoji F, Matsubara T, Kozuma Y, Haratake N, Akamine T, Takamori S, Katsura M, Toyokawa G, Okamoto T, Maehara Y (2017) Preoperative geriatric nutritional risk index: a predictive and prognostic factor in patients with pathological stage I non-small cell lung cancer. Surg Oncol 26(4):483–488. https://doi.org/10.1016/j.suronc.2017.09.006

    Article  PubMed  Google Scholar 

  25. Shoji F, Miura N, Matsubara T, Akamine T, Kozuma Y, Haratake N, Takamori S, Katsura M, Takada K, Toyokawa G, Takenaka T, Yamazaki K, Okamoto T, Takeo S, Maehara Y (2017) Prognostic significance of immune-nutritional parameters for surgically resected elderly lung cancer patients: a multicentre retrospective study. Interact Cardiovasc Thorac Surg. https://doi.org/10.1093/icvts/ivx337

  26. Mori M, Niitsu N, Takagi T, Tomiyama J, Matsue T, Nakagawa Y, Okamoto R (2001) Reduced-dose chop therapy for elderly patients with non-Hodgkin’s lymphoma. Leuk Lymphoma 41(3–4):359–366. https://doi.org/10.3109/10428190109057991

    Article  CAS  PubMed  Google Scholar 

  27. Shah B, Sucher K, Hollenbeck CB (2006) Comparison of ideal body weight equations and published height-weight tables with body mass index tables for healthy adults in the United States. Nutr Clin Pract 21(3):312–319. https://doi.org/10.1177/0115426506021003312

    Article  PubMed  Google Scholar 

  28. Yamada K, Furuya R, Takita T, Maruyama Y, Yamaguchi Y, Ohkawa S, Kumagai H (2008) Simplified nutritional screening tools for patients on maintenance hemodialysis. Am J Clin Nutr 87(1):106–113

    Article  CAS  PubMed  Google Scholar 

  29. Kanda Y (2013) Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant 48(3):452–458. https://doi.org/10.1038/bmt.2012.244

    Article  CAS  PubMed  Google Scholar 

  30. Bozzetti F, Mariani L, Lo Vullo S, Amerio ML, Biffi R, Caccialanza G, Capuano G, Correja I, Cozzaglio L, Di Leo A, Di Cosmo L, Finocchiaro C, Gavazzi C, Giannoni A, Magnanini P, Mantovani G, Pellegrini M, Rovera L, Sandri G, Tinivella M, Vigevani E (2012) The nutritional risk in oncology: a study of 1,453 cancer outpatients. Support Care Cancer 20(8):1919–1928. https://doi.org/10.1007/s00520-012-1387-x

    Article  PubMed  PubMed Central  Google Scholar 

  31. Hebuterne X, Lemarie E, Michallet M, de Montreuil CB, Schneider SM, Goldwasser F (2014) Prevalence of malnutrition and current use of nutrition support in patients with cancer. JPEN J Parenter Enteral Nutr 38(2):196–204. https://doi.org/10.1177/0148607113502674

    Article  PubMed  Google Scholar 

  32. Carson KR, Bartlett NL, McDonald JR, Luo S, Zeringue A, Liu J, Fu Q, Chang SH, Colditz GA (2012) Increased body mass index is associated with improved survival in United States veterans with diffuse large B-cell lymphoma. J Clin Oncol Off J Am Soc Clin Oncol 30(26):3217–3222. https://doi.org/10.1200/jco.2011.39.2100

    Article  Google Scholar 

  33. Jones JA, Fayad LE, Elting LS, Rodriguez MA (2010) Body mass index and outcomes in patients receiving chemotherapy for intermediate-grade B-cell non-Hodgkin lymphoma. Leuk Lymphoma 51(9):1649–1657. https://doi.org/10.3109/10428194.2010.494315

    Article  PubMed  Google Scholar 

  34. Li T, Liu ZG, Liang PQ, Wang HT (2016) Can body mass index predict the outcome of diffuse large B-cell lymphoma? A single-center retrospective study in China. Leuk Lymphoma 58(7):1–6. https://doi.org/10.1080/10428194.2016.1257793

    CAS  Google Scholar 

  35. Weiss L, Melchardt T, Habringer S, Boekstegers A, Hufnagl C, Neureiter D, Hopfinger G, Greil R, Egle A (2014) Increased body mass index is associated with improved overall survival in diffuse large B-cell lymphoma. Ann Oncol 25(1):171–176. https://doi.org/10.1093/annonc/mdt481

    Article  CAS  PubMed  Google Scholar 

  36. Boyle T, Connors JM, Gascoyne RD, Berry BR, Sehn LH, Bashash M, Spinelli JJ (2017) Physical activity, obesity and survival in diffuse large B-cell and follicular lymphoma cases. Br J Haematol 178(3):442–447. https://doi.org/10.1111/bjh.14702

    Article  CAS  PubMed  Google Scholar 

  37. Hong F, Habermann TM, Gordon LI, Hochster H, Gascoyne RD, Morrison VA, Fisher RI, Bartlett NL, Stiff PJ, Cheson BD, Crump M, Horning SJ, Kahl BS (2014) The role of body mass index in survival outcome for lymphoma patients: US intergroup experience. Ann Oncol 25(3):669–674. https://doi.org/10.1093/annonc/mdt594

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Hwang HS, Yoon DH, Suh C, Huh J (2015) Body mass index as a prognostic factor in Asian patients treated with chemoimmunotherapy for diffuse large B cell lymphoma, not otherwise specified. Ann Hematol 94(10):1655–1665. https://doi.org/10.1007/s00277-015-2438-4

    Article  PubMed  Google Scholar 

  39. Kanemasa Y, Shimoyama T, Sasaki Y, Tamura M, Sawada T, Omuro Y, Hishima T, Maeda Y (2017) Analysis of the prognostic value of BMI and the difference in its impact according to age and sex in DLBCL patients. Hematol Oncol. https://doi.org/10.1002/hon.2426

  40. Camus V, Lanic H, Kraut J, Modzelewski R, Clatot F, Picquenot JM, Contentin N, Lenain P, Groza L, Lemasle E, Fronville C, Cardinael N, Fontoura ML, Chamseddine A, Brehar O, Stamatoullas A, Lepretre S, Tilly H, Jardin F (2014) Prognostic impact of fat tissue loss and cachexia assessed by computed tomography scan in elderly patients with diffuse large B-cell lymphoma treated with immunochemotherapy. Eur J Haematol 93(1):9–18. https://doi.org/10.1111/ejh.12285

    Article  CAS  PubMed  Google Scholar 

  41. Lanic H, Kraut-Tauzia J, Modzelewski R, Clatot F, Mareschal S, Picquenot JM, Stamatoullas A, Lepretre S, Tilly H, Jardin F (2014) Sarcopenia is an independent prognostic factor in elderly patients with diffuse large B-cell lymphoma treated with immunochemotherapy. Leuk Lymphoma 55(4):817–823. https://doi.org/10.3109/10428194.2013.816421

    Article  CAS  PubMed  Google Scholar 

  42. de van der Schueren M, Elia M, Gramlich L, Johnson MP, Lim SL, Philipson T, Jaferi A, Prado CM (2014) Clinical and economic outcomes of nutrition interventions across the continuum of care. Ann N Y Acad Sci 1321(1):20–40. https://doi.org/10.1111/nyas.12498

    Article  Google Scholar 

  43. Bairey O, Shacham-Abulafia A, Shpilberg O, Gurion R (2016) Serum albumin level at diagnosis of diffuse large B-cell lymphoma: an important simple prognostic factor. Hematol Oncol 34(4):184–192. https://doi.org/10.1002/hon.2233

    Article  CAS  PubMed  Google Scholar 

  44. Dalia S, Chavez J, Little B, Bello C, Fisher K, Lee JH, Chervenick P, Sokol L, Sotomayor E, Shah B (2014) Serum albumin retains independent prognostic significance in diffuse large B-cell lymphoma in the post-rituximab era. Ann Hematol 93(8):1305–1312. https://doi.org/10.1007/s00277-014-2031-2

    Article  CAS  PubMed  Google Scholar 

  45. Ngo L, Hee SW, Lim LC, Tao M, Quek R, Yap SP, Loong EL, Sng I, Hwan-Cheong TL, Ang MK, Ngeow J, Tham CK, Tan MH, Lim ST (2008) Prognostic factors in patients with diffuse large B cell lymphoma: before and after the introduction of rituximab. Leuk Lymphoma 49(3):462–469. https://doi.org/10.1080/10428190701809156

    Article  CAS  PubMed  Google Scholar 

  46. Marian M, August DA (2014) Prevalence of malnutrition and current use of nutrition support in cancer patient study. JPEN J Parenter Enteral Nutr 38(2):163–165. https://doi.org/10.1177/0148607113506940

    Article  PubMed  Google Scholar 

  47. Forrest LM, McMillan DC, McArdle CS, Angerson WJ, Dunlop DJ (2003) Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer. Br J Cancer 89(6):1028–1030. https://doi.org/10.1038/sj.bjc.6601242

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Ignacio de Ulibarri J, Gonzalez-Madrono A, de Villar NG, Gonzalez P, Gonzalez B, Mancha A, Rodriguez F, Fernandez G (2005) CONUT: a tool for controlling nutritional status. First validation in a hospital population. Nutr Hosp 20(1):38–45

    CAS  PubMed  Google Scholar 

  49. McMillan DC, Crozier JE, Canna K, Angerson WJ, McArdle CS (2007) Evaluation of an inflammation-based prognostic score (GPS) in patients undergoing resection for colon and rectal cancer. Int J Color Dis 22(8):881–886. https://doi.org/10.1007/s00384-006-0259-6

    Article  Google Scholar 

  50. Onodera T, Goseki N, Kosaki G (1984) Prognostic nutritional index in gastrointestinal surgery of malnourished cancer patients. Nihon Geka Gakkai zasshi 85(9):1001–1005

    CAS  PubMed  Google Scholar 

  51. Iseki Y, Shibutani M, Maeda K, Nagahara H, Ohtani H, Sugano K, Ikeya T, Muguruma K, Tanaka H, Toyokawa T, Sakurai K, Hirakawa K (2015) Impact of the preoperative Controlling Nutritional Status (CONUT) score on the survival after curative surgery for colorectal cancer. PLoS One 10(7):e0132488. https://doi.org/10.1371/journal.pone.0132488

    Article  PubMed  PubMed Central  Google Scholar 

  52. Toyokawa T, Kubo N, Tamura T, Sakurai K, Amano R, Tanaka H, Muguruma K, Yashiro M, Hirakawa K, Ohira M (2016) The pretreatment Controlling Nutritional Status (CONUT) score is an independent prognostic factor in patients with resectable thoracic esophageal squamous cell carcinoma: results from a retrospective study. BMC Cancer 16(1):722. https://doi.org/10.1186/s12885-016-2696-0

    Article  PubMed  PubMed Central  Google Scholar 

  53. Thieblemont C, Coiffier B (2007) Lymphoma in older patients. J Clin Oncol Off J Am Soc Clin Oncol 25(14):1916–1923. https://doi.org/10.1200/jco.2006.10.5957

    Article  Google Scholar 

  54. Klapper W, Kreuz M, Kohler CW, Burkhardt B, Szczepanowski M, Salaverria I, Hummel M, Loeffler M, Pellissery S, Woessmann W, Schwanen C, Trumper L, Wessendorf S, Spang R, Hasenclever D, Siebert R (2012) Patient age at diagnosis is associated with the molecular characteristics of diffuse large B-cell lymphoma. Blood 119(8):1882–1887. https://doi.org/10.1182/blood-2011-10-388470

    Article  CAS  PubMed  Google Scholar 

  55. Duran Alert P, Mila Villarroel R, Formiga F, Virgili Casas N, Vilarasau Farre C (2012) Assessing risk screening methods of malnutrition in geriatric patients: Mini Nutritional Assessment (MNA) versus Geriatric Nutritional Risk Index (GNRI). Nutr Hosp 27(2):590–598. https://doi.org/10.1590/s0212-16112012000200036

    CAS  PubMed  Google Scholar 

  56. Kinugasa Y, Kato M, Sugihara S, Hirai M, Yamada K, Yanagihara K, Yamamoto K (2013) Geriatric nutritional risk index predicts functional dependency and mortality in patients with heart failure with preserved ejection fraction. Circ J 77(3):705–711

    Article  CAS  PubMed  Google Scholar 

  57. Matsumura T, Mitani Y, Oki Y, Fujimoto Y, Ohira M, Kaneko H, Kawashima T, Nishio M, Ishikawa A (2015) Comparison of Geriatric Nutritional Risk Index scores on physical performance among elderly patients with chronic obstructive pulmonary disease. Heart Lung 44(6):534–538. https://doi.org/10.1016/j.hrtlng.2015.08.004

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

We would like to thank all the patients who took part in this study.

Author information

Authors and Affiliations

  1. Department of Medical Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, Japan

    Yusuke Kanemasa, Tatsu Shimoyama & Yasushi Omuro

  2. Department of Clinical Research Support, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan

    Yuki Sasaki

  3. Department of Pathology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan

    Tsunekazu Hishima

Authors
  1. Yusuke Kanemasa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tatsu Shimoyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yuki Sasaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tsunekazu Hishima
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yasushi Omuro
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yusuke Kanemasa.

Ethics declarations

The protocol for this study was approved by the institutional ethics review board of our hospital, and informed consent for retrospective analysis was obtained from all patients.

Conflict of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kanemasa, Y., Shimoyama, T., Sasaki, Y. et al. Geriatric nutritional risk index as a prognostic factor in patients with diffuse large B cell lymphoma. Ann Hematol 97, 999–1007 (2018). https://doi.org/10.1007/s00277-018-3273-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-018-3273-1

Keywords

Search

Navigation