Abstract
We tested the role of the lymphocyte chemokine XCL1 in a murine model of chronic obstructive pulmonary disease (COPD). COPD was instigated in mice by a 12-week exposure to cigarette smoke. Some COPD animals additionally received intranasal injections of recombinant XCL1. We demonstrated that the expression of CD4+ T cells diminished, while CD8+ counts increased in the lungs of COPD mice, and that these changes were further aggravated by exogenous XCL1. The levels of XCL1 negatively correlated with CD4+/CD8+ ratio (r = −0.945, p < 0.05). In addition, the levels of this chemokine negatively correlated with the levels of interleukin-2, the lymphokine that is produced by activated CD4+. This observation further supported negative association between XCL1 and CD4+ response in an experimental model of COPD. In conclusion, murine model of COPD is characterized by elevated levels of XCL1, increased counts of CD8+ T cells and diminished ratio of CD4+/CD8+ cells, and decreased activity of CD4+ T cells. This indicates that XCL1 is involved in chronic inflammatory processes in COPD and may be an important pharmacological target in this disease.
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Zhuo, S., Li, N., Zheng, Y. et al. Expression of the Lymphocyte Chemokine XCL1 in Lung Tissue of COPD Mice, and Its Relationship to CD4+/CD8+ Ratio and IL-2. Cell Biochem Biophys 73, 505–511 (2015). https://doi.org/10.1007/s12013-015-0690-9
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DOI: https://doi.org/10.1007/s12013-015-0690-9