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Assessment of Titanium Dioxide Nanoparticles (TiO2-NPs) Induced Hepatotoxicity and Ameliorative Effects of Cinnamomum cassia in Sprague-Dawley Rats

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Abstract

This study assessed the protective effects of Cinnamomum cassia (cinnamon) bark extract in rats exposed to titanium dioxide nanoparticles or titanium dioxide bulk salt. For in vivo evaluation of the ameliorative role of the cinnamon extract, the experimental groups were orally administered with the cinnamon extract at different dose levels (50 or 100 or 150 mg/kg bodyweight) along with the subcutaneous injections of 150 mg/kg bodyweight titanium dioxide nanoparticles or titanium dioxide bulk salt. The extract showed significant ameliorative role on the antioxidant system in response to elevated levels of titanium dioxide nanoparticles or titanium dioxide bulk salt-induced oxidative stress. It aided in the recovery of the antioxidant system as well as protective role in histological damages and some haematological parameters in the rat liver treated with titanium dioxide nanoparticles or titanium dioxide bulk salt.

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Authors and Affiliations

  1. Department of Zoology, Government College University, Faisalabad, Pakistan

    Muhammad Shakeel, Farhat Jabeen, Muhammad Ali, Muhammad Saleem Khan, Adeel Khalid, Samina Shabbir & Muhammad Saleem Asghar

  2. Institute of Pure and Applied Biology, Bahauddin Zakariya University, Multan, Pakistan

    Rehana Iqbal

  3. School of Agriculture, Food and Rural Development, Newcastle University, Newcastle upon Tyne, UK

    Abdul Shakoor Chaudhry

  4. Department of Botany, Government College University, Faisalabad, Pakistan

    Sadia Zafar

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  1. Muhammad Shakeel
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Correspondence to Farhat Jabeen.

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All procedures performed in this study involving rats were in accordance with the research ethical standards of the Government College University, Faisalabad, Pakistan.

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Shakeel, M., Jabeen, F., Iqbal, R. et al. Assessment of Titanium Dioxide Nanoparticles (TiO2-NPs) Induced Hepatotoxicity and Ameliorative Effects of Cinnamomum cassia in Sprague-Dawley Rats. Biol Trace Elem Res 182, 57–69 (2018). https://doi.org/10.1007/s12011-017-1074-3

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