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Selenium and Topiramate Attenuates Blood Oxidative Toxicity in Patients with Epilepsy: A Clinical Pilot Study

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Abstract

It is well known that oxidative stress plays an important role in the etiology of epilepsy. We investigated effects of selenium (Se) and topiramate (TPM) combination supplementation on antioxidant and oxidant values in control and patients with epilepsy and refractory epilepsy. For the aim, we used control (n = 19), epilepsy + TPM (n = 19), epilepsy + TPM + Se (n = 15) groups. We also used control (n = 15), refractory epilepsy (n = 15), and refractory epilepsy + Se (n = 8) groups. TPM (0.2 mg/daily) and Se, as sodium selenite (twice daily with 0.1 mg doses), were orally supplemented to the patients for 45 days. Erythrocyte lipid peroxidation levels were higher in refractory epilepsy groups than in control although its level and seizure numbers were decreased in TPM and TPM + Se supplemented groups of the patients. The erythrocyte reduced glutathione (GSH), glutathione peroxidase (GSH-Px), plasma total antioxidant status (TAS), and vitamin E concentration in refractory epilepsy group were lower than in control. However, the erythrocyte and plasma TAS, erythrocyte GSH and GSH-Px, and plasma vitamins A and C values were increased either by Se or Se + TPM in epilepsy and refractory epilepsy groups. There were no effects of TPM and Se on plasma β-carotene values in the groups. In conclusion, TPM and selenium caused protective effects on the epilepsy and refractory epilepsy-induced oxidative injury by inhibiting free radical production and supporting antioxidant redox system.

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Abbreviations

GSH:

Glutathione

GSH-Px:

Glutathione peroxidase

LP:

Lipid peroxidation

NADH:

Nicotinamid Adenine Dinucleotide Dehydrogenase

PUFA:

Polyunsaturated fatty acid

ROS:

Reactive oxygen species

TPM:

Topiramate

TAS:

Total antioxidant status

VGCC:

Voltage-gated calcium channels

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Acknowledgments

The study was performed Neuroscience Research Center of Suleyman Demirel University, Isparta, Turkey. There is no financial support and conflict of interest in the current study.

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Authors and Affiliations

  1. Department of Neurology, Medical Faculty, Suleyman Demirel University, Isparta, Turkey

    Vedat Ali Yürekli

  2. Neurocience Research Center, Suleyman Demirel University, Tıp Fakültesi Binasi, TR-32260, Isparta, Turkey

    Mustafa Nazıroğlu

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  1. Vedat Ali Yürekli
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  2. Mustafa Nazıroğlu
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Correspondence to Mustafa Nazıroğlu.

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Yürekli, V.A., Nazıroğlu, M. Selenium and Topiramate Attenuates Blood Oxidative Toxicity in Patients with Epilepsy: A Clinical Pilot Study. Biol Trace Elem Res 152, 180–186 (2013). https://doi.org/10.1007/s12011-013-9616-9

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  • DOI: https://doi.org/10.1007/s12011-013-9616-9

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