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Selenium and antioxidant levels in children with intractable epilepsy receiving ketogenic diet

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Abstract

Ketogenic diet is a high-fat, low-carbohydrate, and adequate-protein diet. It is well-established as a treatment option for drug-resistant childhood epilepsies. Our study aimed to evaluate Selenium levels and oxidative stress in children receiving ketogenic diet for intractable seizures for 6 months. This is a comparative case–control study included 90 children under 6 years age. They were subdivided into three groups. Group I: Thirty patients with drug-resistant epilepsy under antiepileptic drugs only. Group II: Thirty patients with drug-resistant epilepsy under treatment with ketogenic diet for 6 months and antiepileptic drugs. Group III: Thirty age and sex-matched healthy children as controls. Full history taking with special emphasis on severity and frequency of seizures, neurological examination, anthropometric measurements and laboratory analysis for serum Malonaldehyde, and total antioxidant capacity and Selenium were done for all participants. The frequency and severity of seizures were significantly lower in group II receiving ketogenic diet than group I on antiepileptic drugs only. Selenium levels were significantly lower in epileptic patients in comparison to controls. However, it was markedly lower in the ketogenic diet group. Malonaldehyde levels were significantly higher in epileptic children in comparison to controls, with lower values among ketogenic diet group when compared to patients on antiepileptic drugs only. Total antioxidant capacity levels were significantly lower in epileptic patients in comparison to controls, with higher values among ketogenic diet group as compared to epileptic patients on pharmacological treatment. Ketogenic diet is an effective treatment for refractory epilepsy for its anti-epileptic mechanism. It also may exert antioxidant effects. The nutrient content of the ketogenic diet may not meet the recommended daily allowance for selenium. So, this should be taken into consideration for supplementation of minerals in adequate amounts for patients receiving this diet.

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Abbreviations

AED:

Antiepileptic drugs

ILAE:

International League Against Epilepsy

KD:

Ketogenic diet

MDA:

Malonaldehyde

TAC:

Total antioxidant capacity

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Authors and Affiliations

  1. Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt

    Omnia F. El-Rashidy & Yasmin G. Elgendy

  2. Child Health Department, National Research Centre, Doki, Giza, Egypt

    Mai M. Youssef, Manal A. Mohsen & Sarah A. Dawh

  3. Medical Biochemistry Department, National Research Centre, Doki, Giza, Egypt

    Safaa M. Morsy

  4. Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt

    Khaled Saad

Authors
  1. Omnia F. El-Rashidy
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  2. Mai M. Youssef
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  3. Yasmin G. Elgendy
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  4. Manal A. Mohsen
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  5. Safaa M. Morsy
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  6. Sarah A. Dawh
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  7. Khaled Saad
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Correspondence to Khaled Saad.

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El-Rashidy, O.F., Youssef, M.M., Elgendy, Y.G. et al. Selenium and antioxidant levels in children with intractable epilepsy receiving ketogenic diet. Acta Neurol Belg 120, 375–380 (2020). https://doi.org/10.1007/s13760-020-01310-9

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  • DOI: https://doi.org/10.1007/s13760-020-01310-9

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