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Mitochondrial dysfunction and oxidative stress: a contributing link to acquired epilepsy?

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Abstract

Mitochondrial dysfunction and oxidative stress contribute to several neurologic disorders and have recently been implicated in acquired epilepsies such as temporal lobe epilepsy (TLE). Acquired epilepsy is typically initiated by a brain injury followed by a “latent period” whereby molecular, biochemical and other cellular alterations occur in the brain leading to chronic epilepsy. Mitochondrial dysfunction and oxidative stress are emerging as factors that not only occur acutely as a result of precipitating injuries such as status epilepticus (SE), but may also contribute to epileptogenesis and chronic epilepsy. Mitochondria are the primary site of reactive oxygen species (ROS) making them uniquely vulnerable to oxidative damage that may affect neuronal excitability and seizure susceptibility. This mini-review provides an overview of evidence suggesting the role of mitochondrial dysfunction and oxidative stress as acute consequences of injuries that are known to incite chronic epilepsy and their involvement in the chronic stages of acquired epilepsy.

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  1. Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver Anschutz Medical Campus, 12700 East 19th Avenue, Aurora, CO, 80045, USA

    Simon Waldbaum & Manisha Patel

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  1. Simon Waldbaum
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  2. Manisha Patel
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Correspondence to Manisha Patel.

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Waldbaum, S., Patel, M. Mitochondrial dysfunction and oxidative stress: a contributing link to acquired epilepsy?. J Bioenerg Biomembr 42, 449–455 (2010). https://doi.org/10.1007/s10863-010-9320-9

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