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Spectroscopic Behavior and Biological Activity of K2[VO(O2)NTA]·2H2O

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Abstract

The dihydrated potassium salt of the complex anion [VO(O2)NTA]2− (NTA = nitrilotriacetate anion, [N(CH2-COO)3]3−) was thoroughly characterized by electronic and vibrational (infrared and Raman) spectroscopies. The bioactivity of the complex on the cell proliferation was tested on three cell lines in culture (UMR106 rat osteosarcoma-derived cells, Caco-2 derived from a human colon adenocarcinoma, and RAW 264.7, a macrophage murine cell line).

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Acknowledgments

This work has been supported by the Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina, CONICET (PIP 5078 and 6366), and the National University of La Plata. It is also a part of the PROSUL Project Nr. 490.600/2007-08 supported by CNPq (Brazil) and of the CYTED network RIIDFCM (Red Temática 209 RT0380). D.A.B., S.B.E., and E.J.B. are members of the Research Career from CONICET.

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Authors and Affiliations

  1. Cátedra de Química Inorgánica, Departamento Estrella Campos, Facultad de Química, Universidad de la República, 11800, Montevideo, Uruguay

    Gabriel Arrambide & Dinorah Gambino

  2. Cátedra de Bioquímica Patológica, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900, La Plata, Argentina

    Daniel A. Barrio & Susana B. Etcheverry

  3. Centro de Química Inorgánica (CEQUINOR/CONICET,UNLP), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, C. Correo 962, 1900, La Plata, Argentina

    Susana B. Etcheverry & Enrique J. Baran

Authors
  1. Gabriel Arrambide
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  2. Daniel A. Barrio
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  3. Susana B. Etcheverry
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  4. Dinorah Gambino
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  5. Enrique J. Baran
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Corresponding authors

Correspondence to Susana B. Etcheverry or Enrique J. Baran.

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Arrambide, G., Barrio, D.A., Etcheverry, S.B. et al. Spectroscopic Behavior and Biological Activity of K2[VO(O2)NTA]·2H2O. Biol Trace Elem Res 136, 241–248 (2010). https://doi.org/10.1007/s12011-009-8538-z

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  • DOI: https://doi.org/10.1007/s12011-009-8538-z

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