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Synthesis, structural characterization, and cytotoxicity of nickel(II) complexes with 1H-tetrazole-5-acetic acid and oligopyridines

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Abstract

Nickel(II) complexes of 1H-tetrazol-5-acetic acid (H2L) and oligopyridines (1,10-phenanthroline /2,2’-bipyridine derivatives) have been synthesized and characterized by physicochemical methods (elemental and thermogravimetric analysis, powder X-ray diffraction, and IR spectroscopy). The behavior of the complexes in solution was studied by UV–Vis spectroscopy, conductometry, and mass spectrometry. The stability of the complexes over 48 h in aqueous solution and in phosphate-buffered saline was demonstrated using UV–Vis spectroscopy. These compounds were investigated for their cytotoxic and cytostatic activity against HepG2 (hepatocellular carcinoma), and Hep2 (larynx carcinoma) human cancer cell lines. Cytotoxicity was also studied on human non-cancerous cell line MRC-5 (lung fibroblast). All the compounds did not show cytotoxic activity against the tested cell lines in 1–50-µM concentration range. However, compounds showed a cytostatic effect against HepG2 and Hep2 cell lines. The most pronounced cytostatic properties were found for the complex [Ni(dmphen)2L]·2C2H5OH·2H2O (1). In addition, we report three new crystal structures: [Ni(phen)2L]·H2O, [Ni(dmbipy)2L]·2C2H5OH, and [Ni(dmphen)2L]·2C2H5OH·2H2O, where L2– behaves as a bidentate ligand which is coordinated to the Ni(II) ion via N,O atoms.

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Acknowledgements

The authors thank Anna P. Zubareva and Natalia N. Komardina for the elemental analysis, Aleksandra A. Shapovalova for IR spectroscopy, Anastasia O. Matveeva and Ilya V. Korolkov for the powder X-ray analysis data, and Vasiliy N. Yudin for providing the data collected in the XRD Facility of NIIC SB RAS. The research (Nikolaev Institute of Inorganic Chemistry SB RAS) was supported by the Ministry of Science and Higher Education of the Russian Federation, No. 121031700321-3. The work was performed using the equipment of the Center for Collective Use "Proteomic Analysis," supported by funding from the Ministry of Science and Higher Education of the Russian Federation (agreement No. 075-15-2021-691).

Funding

This work was supported by the Russian Science Foundation (Project no. 20–73-10207).

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Authors and Affiliations

  1. Nikolaev Institute of Inorganic Chemistry SB RAS, 3, Acad. Lavrentiev Ave., Novosibirsk, Russia, 630090

    Ekaterina A. Ermakova, Yuliya A. Golubeva, Ksenia S. Smirnova, Dmitriy G. Sheven’ & Elizaveta V. Lider

  2. Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine (IMBB FRC FTM), 2/12, Timakova Str, Novosibirsk, Russia, 630060

    Lyubov S. Klyushova

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  1. Ekaterina A. Ermakova
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Contributions

E.A.E. wrote the main manuscript text, investigation, visualization Yu.A.G.: investigation, review and editing of the manuscript K.S.S.: investigation, visualization, wrote description of crystal structures L.S.K.: investigation in vitro cytotoxicity study, visualization D.G.Sh.: investigation by mass spectrometry E.V.L.: review and editing of the manuscript, conceptualization, supervision

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Correspondence to Elizaveta V. Lider.

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Ermakova, E.A., Golubeva, Y.A., Smirnova, K.S. et al. Synthesis, structural characterization, and cytotoxicity of nickel(II) complexes with 1H-tetrazole-5-acetic acid and oligopyridines. Transit Met Chem (2024). https://doi.org/10.1007/s11243-024-00573-y

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