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Change in Adipokines and Gastrointestinal Hormones After Bariatric Surgery: a Meta-analysis

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Abstract

Purpose

The study aimed to perform a meta-analysis about the change in adipokines and gastrointestinal hormones after bariatric surgery in patients with obesity.

Materials and Methods

We searched the Cochrane Central Register of Controlled Trials, EMBASE, and PubMed for related articles and used Review Manager 5.4 for data aggregation. Sensitivity and subgroup analysis were also conducted when feasible.

Results

As a result, 95 articles involving 6232 patients were included in the meta-analysis. After bariatric surgery, the levels of leptin, ghrelin, C-reactive protein (CRP), interleukin-6 (IL-6), high-sensitivity C-reactive protein (Hs-CRP), tumor necrosis, factor-α (TNF-α), and interleukin-1β (IL-1β) reduced, while adiponectin, glucagon-like peptide-1 (GLP-1), and peptide YY (PYY) levels increased significantly. Subgroup analysis indicated that there was a more significant reduction in leptin level with a longer follow-up time. OAGB had a greater effect on increasing adiponectin level compared with other procedures. SG procedure would bring about reduced ghrelin, while BPD resulted in increased ghrelin. Meta-regression analysis found that publication year, study design, number of patients, preoperative age, preoperative BMI, and quality assessment score were not significantly related to change in leptin, adiponectin, and ghrelin levels.

Conclusion

Bariatric surgery was associated with a significant decrease in leptin, ghrelin, CRP, IL-6, Hs-CRP, TNF-α, and IL-1β, as well as increase in adiponectin, GLP-1, and PYY levels.

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Data Availability

The analyzed datasets generated during the study are available from the corresponding author on reasonable request.

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Funding

The work was supported by the Fundamental Research Funds for the Central Universities (21622304) and the Basic and Applied Basic Research Project of Guangzhou Basic Research Program (SL2023A04J01245).

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Author notes

  1. Jiayun Huang, Yanya Chen, and Bingsheng Guan contributed equally to this work.

Authors and Affiliations

  1. School of Nursing, Jinan University, Guangzhou, 510632, China

    Jiayun Huang, Yanya Chen & Xuan Wang

  2. Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong, 999077, China

    Yanya Chen

  3. Department of Gastrointestinal Surgery, First Affiliated Hospital of Jinan University, Guangzhou, 510632, China

    Cunchuan Wang, Jingge Yang & Bingsheng Guan

Authors
  1. Jiayun Huang
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  2. Yanya Chen
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  3. Xuan Wang
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  4. Cunchuan Wang
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  5. Jingge Yang
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  6. Bingsheng Guan
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Corresponding authors

Correspondence to Jingge Yang or Bingsheng Guan.

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Key Points

1. Bariatric surgery was associated with a significant decrease in leptin, ghrelin, CRP, IL-6, Hs-CRP, TNF-α, and IL-1β levels.

2. The levels of adiponectin, GLP-1, and PYY increased after bariatric surgery.

3. Publication year, study design, number of patients, preoperative age, preoperative BMI, and quality assessment score were not significantly related to change in leptin, adiponectin, and ghrelin levels.

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Huang, J., Chen, Y., Wang, X. et al. Change in Adipokines and Gastrointestinal Hormones After Bariatric Surgery: a Meta-analysis. OBES SURG 33, 789–806 (2023). https://doi.org/10.1007/s11695-022-06444-8

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  • DOI: https://doi.org/10.1007/s11695-022-06444-8

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