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Short-Term Impact of Laparoscopic Sleeve Gastrectomy on Serum Cartonectin and Vaspin Levels in Obese Subjects

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Abstract

Background

Cartonectin is a potent anti-inflammatory adipokine that might be implicated in metabolism and energy storage. Our objective was to evaluate the influence of weight reduction following laparoscopic sleeve gastrectomy (LSG) on serum cartonectin and vaspin levels.

Subjects and Methods

Thirty-two individuals (29 female and 3 male) with morbid obesity underwent LSG. Anthropometric indices, lipid profile, fasting serum concentrations of glucose, insulin, vaspin, and cartonectin were measured prior and 3 months after LSG. Insulin sensitivity was determined using the homeostasis model assessment of insulin resistance (HOMA-IR).

Results

Following LSG, circulating cartonectin level increased significantly while serum vaspin was significantly decreased. The percentage change of serum cartonectin level correlated negatively with the percentage changes in body mass index, waist circumference, and waist-hip ratio and positively with percentage changes in LDL-C, triglycerides, and HOMA-IR after adjustment for age and sex. Moreover, the changes in vaspin concentration positively correlated with the changes in insulin level and HOMA-IR after adjustment for age and sex. In a multiple stepwise linear regression model, the changes in waist circumference explained 13% variability of changes in cartonectin level while the changes in HOMA-IR and LDL-C were responsible for 31% of the variability in changes of vaspin level.

Conclusion

LSG-induced weight loss rapidly increases serum cartonectin level and decreases the serum vaspin level in morbidly obese subjects. The changes in cartonictin level seem to be influenced by the changes of waist circumference while the changes of HOMA-IR and LDL-C might be determinant factors of the changes in vaspin level.

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Acknowledgments

We would like to thank a lot Fady Makram at Surgery Department, Faculty of Medicine, Ain Shams University for his effort and cooperation in sample collection to elaborate this work.

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Authors and Affiliations

  1. Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt

    Doaa M. Ibrahim & Ahmed F. Soliman

  2. Internal Medicine and Endocrinology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

    Nagwa R. Mohamed

  3. Internal Medicine Department, El-Mataria Teaching Hospital, The General Organization for Teaching Hospitals and Institutes, Cairo, Egypt

    Tarek A. Fouad

Authors
  1. Doaa M. Ibrahim
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  2. Nagwa R. Mohamed
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  3. Tarek A. Fouad
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  4. Ahmed F. Soliman
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Correspondence to Doaa M. Ibrahim.

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The authors declare that they have no conflict of interest.

Ethical Approval

All study protocols were conducted in accordance with the principles of the Declaration of Helsinki 1972 and were approved by the ethics committee of Ain Shams University Hospitals.

Informed Consent

Written informed consent was obtained from all participants in the study.

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Ibrahim, D.M., Mohamed, N.R., Fouad, T.A. et al. Short-Term Impact of Laparoscopic Sleeve Gastrectomy on Serum Cartonectin and Vaspin Levels in Obese Subjects. OBES SURG 28, 3237–3245 (2018). https://doi.org/10.1007/s11695-018-3306-9

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  • DOI: https://doi.org/10.1007/s11695-018-3306-9

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