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Ovarian Toxicity and Epigenetic Mechanisms of Phthalates and Their Metabolites

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Summary

Ovary plays an important role in the female reproductive system. The maintenance and regulation of ovarian function are affected by various physical and chemical factors. With the development of industrialization, environmental pollutants have caused great harm to public health. Phthalates, as a class of endocrine-disrupting chemicals (EDCs), are synthesized and used in large quantities as plasticizers due to their chemical properties. They are easily released into environment because of their noncovalent interactions with substances, causing human exposure and possibly impairing ovary. In recent years, more and more attention has been paid to the role of epigenetics in the occurrence and development of diseases. And it is urgent to study the role of methylation, gene imprinting, miRNA, and other epigenetic mechanisms in reproductive toxicology.

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Authors and Affiliations

  1. Reproductive Medical Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Hua-hua Jiang, Yao-yao Du & Yu-feng Li

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  1. Hua-hua Jiang
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  2. Yao-yao Du
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  3. Yu-feng Li
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Correspondence to Yu-feng Li.

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The authors declare that there is no conflict of interest with any financial organization or corporation or individual that can inappropriately influence this work.

The study was supported by the National Natural Science Foundation of China (No. 81571508 and No. 81771654), the National Natural Science Youth Foundation of China (No. 81701520) and the Self-dependent Innovation Research Funding of Huazhong University of Science and Technology (No. 2017KFYXJJ121).

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Jiang, Hh., Du, Yy. & Li, Yf. Ovarian Toxicity and Epigenetic Mechanisms of Phthalates and Their Metabolites. CURR MED SCI 41, 236–249 (2021). https://doi.org/10.1007/s11596-021-2342-1

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  • DOI: https://doi.org/10.1007/s11596-021-2342-1

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