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Salt taste threshold and contributory factors of chronic kidney disease patients: a cross-sectional study

  • Nephrology - Original Paper
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Abstract

Propose

High salt intake, correlated with high salt taste threshold, may accelerate renal injury in chronic kidney disease (CKD) patients. However, few studies have focused on factors that influence salt taste threshold. Therefore, we aimed to identify factors that influence the salt taste threshold of CKD patients, to provide more precise salt restriction recommendations in dietary therapy.

Methods

Between April 2016 and March 2019, we measured the salt taste threshold of 1019 CKD patients, aged 22–78 years, from 52 hospitals across southwestern China, and then we performed a cross-sectional study.

Results

The mean salt taste threshold was 0.37 ± 0.16% NaCl. There were 115 (11.3%), 670 (65.7%), and 234 (23.0%), respectively, patients who had low (≤ 0.1% NaCl), medium (0.1–0.4% NaCl), and high (> 0.4% NaCl) salt taste thresholds. One-way ANOVA and regression results revealed that sex (male), age, decreased estimated glomerular filtration rate, and absence of salt restriction were factors that influenced CKD groups with high salt taste threshold.

Conclusion

We found an independent correlation between contributory factors including sex, age, eGFR, and salt restriction behavior of subjects with the salt taste threshold of CKD patients. Our findings also offer insights on salt taste thresholds that could be useful for clinicians advising salt restriction to impair the salt taste sensitivity of the corresponding populations.

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Acknowledgements

The authors thank Dr. J.X. Guo from Chengdu University for his support to discuss the data statistics. The authors thank AiMi Academic Services (www.aimieditor.com) for English language editing and review services. This work was financially supported by the Sichuan Provincial People's Hospital (no specific grant number).

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Authors and Affiliations

  1. Surgical Department, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, 610072, Chengdu, China

    Ya Wu, Fengqin Liao, Lidan Liao, Yulian Yang, Min Fan & Rong Tang

  2. Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, 610072, China

    Ya Wu, Fengqin Liao, Lidan Liao, Yulian Yang, Min Fan & Rong Tang

  3. Respiratory and Critical Care Medicine Department, Chongqing Nanchuan District People’s Hospital, Chongqing, 408499, China

    Fanglu Li

Authors
  1. Ya Wu
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  2. Fengqin Liao
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  3. Lidan Liao
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  4. Fanglu Li
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  5. Yulian Yang
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  6. Min Fan
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  7. Rong Tang
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Contributions

YW, MF and RT designed the experiments and wrote the manuscript. LL, FL and YY collected the data of salt restriction behaviors and spot tests for urine sodium. MF and FL collected the data from electronic medical records. YW, MF and RT performed and analyzed the AVONA results and regression relations. YW wrote and revised the manuscript. WY and MF supervised the cross-sectional study. All authors contributed to the scientific discussion and edited the manuscript.

Corresponding authors

Correspondence to Ya Wu or Min Fan.

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Wu, Y., Liao, F., Liao, L. et al. Salt taste threshold and contributory factors of chronic kidney disease patients: a cross-sectional study. Int Urol Nephrol 55, 1211–1218 (2023). https://doi.org/10.1007/s11255-022-03403-1

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  • DOI: https://doi.org/10.1007/s11255-022-03403-1

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