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Effect of Chronic Kidney Disease on Taste Function: A Case Control Study among Nigerian

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Taste dysfunction has been associated with chronic kidney disease (CKD) especially end stage kidney disease (ESKD) and also implicated as one of the predisposing factors for the prevalent malnutrition, muscle wasting and impaired quality of life among patients with CKD. To assess the taste function and determine the pattern of taste dysfunction in patients with CKD attending the University College Hospital, Ibadan. This was a cross sectional, hospital-based case–control study of adult patients with CKD. The control group were age and sex matched without CKD. Interviewer-assisted questionnaires were administered on all participants to obtain clinical information concerning demographics, clinical data on kidney disease and taste dysfunction. The four basic taste modalities namely; sweet, sour, bitter and salt taste senses of the participants were tested with validated “taste strips”. There were 100 patients with CKD and 100 healthy controls, age ranges between 19 and 86 years (mean ± SD = 46.3 ± 13.9 years) and 20 and 85 years (mean ± SD = 43.4 ± 14.9 years), respectively. There was no statistically significant difference between cases and control gender distribution (p = 0.57). Hypogeusia was found in 27.0% of CKD patients with specific taste modalities dysfunction for salt, sour, sweet and bitter taste of 13.0, 24.0, 13.0 and 17.0%, respectively. The controls only had specific taste modalities dysfunction for salt, sour and bitter taste of 1.0% for each of the taste modalities. The mean total taste scores in the cases and controls were − 9.8 ± 3.2 and 13.4 ± 1.5 (p = 0.001), respectively. The mean taste scores were significantly lower among the cases than controls, salt taste-2.82 ± 1.1 and 3.7 ± 0.7 (p = 0.001), sour taste − 2.2 ± 1.0 and 3.2 ± 0.7 (p = 0.001), sweet taste-, 2.9 ± 1.8 and 3.8 ± 0.5 (p = 0.001), bitter taste − 1.9 ± 1.2 and 2.8 ± 0.9 (p = 0.001). Taste dysfunction is prevalent among patients with CKD and the affectation involves all taste modalities.

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References

  1. Raff AC, Lieu S, Melamed ML, Ponda Z, Meyer M, Timothy W et al (2008) Relationship of impaired olfactory function in ESRD to malnutrition and retained uremic molecules. Am J Kidney Dis 52(1):102–110

    Article  CAS  Google Scholar 

  2. National Kidney Foundation (2002) K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, clasification and stratification. Am J Kidney Dis 39:1–266

    Google Scholar 

  3. Mcmahon EJ, Campbell KL, Bauer JD (2014) Taste perception in kidney disease and relationship to dietary sodium intake. Appetite 83:236–241

    Article  Google Scholar 

  4. Manley KJ, Haryono RY, Keast RSJ (2012) Taste changes and saliva composition in chronic kidney disease. Renal Soc Aust J 8(2):56–60

    Google Scholar 

  5. Middleton RA, Allman-farinelli MA (1999) Taste sensitivity is altered in patients with chronic renal failure receiving continuous ambulatory peritoneal dialysis. J Nutr 129:122–125

    Article  CAS  Google Scholar 

  6. Oyetola EO, Owotade FJ, Agbelusi GA, Fatusi OA, Sanusi AA (2015) Oral findings in chronic kidney disease: implications for management in developing countries. BMC Oral Health 24:1–8

    Google Scholar 

  7. Bromley SM, Doty RL (2015) Clinical disorders affecting taste: an update. In: Handbook of olfaction and gustation, 3rd edn. Wiley, pp 887–910

  8. Kusaba T, Mori Y, Masami O, Neriya H, Takaomi A, Chikako S et al (2009) Sodium restriction improves the gustatory threshold for salty taste in patients with chronic kidney disease. Kidney Int 76:638–643

    Article  CAS  Google Scholar 

  9. Fasunla AJ, Daniel A, Nwankwo U, Kuti KM, Nwaorgu OG, Akinyinka OO (2016) Evaluation of olfactory and gustatory function of HIV infected women. AIDS Res Treat 2016:1–8

    Article  Google Scholar 

  10. Mueller C, Kallert S, Renner B, Stiassny K, Temmel AFP, Hummel T et al (2003) Quantitative assessment of gustatory funtion in a clinical context using impregnated “taste strips.” Rhinology 41:2–6

    CAS  Google Scholar 

  11. Landis BN, Welge-luessen A, Mueller CA, Bramerson A, Bende M, Hummel T et al (2009) “Taste strips”—a rapid, lateralized, gustatory bedside identification test based on impregnated filter papers. J Neurol 256:242–248

    Article  Google Scholar 

  12. Kolimechkov S (2014) Body mass index. STK Sport UK, pp 1–7

  13. Pingel J, Ostwald J, Pau HW, Hummel T, Just T (2010) Normative data for a solution-based taste test. Eur Arch Otorhinolaryngol 267:1911–1917

    Article  Google Scholar 

  14. Breslin PAS, Spector AC (2008) Mammalian taste perception. Curr Biol 18(4):148–155

    Article  Google Scholar 

  15. Chandrashekar J, Hoon MA, Ryba NJP, Zuker CS (2006) The receptors and cells for mammalian taste. Nature 444(7117):288–294

    Article  CAS  Google Scholar 

  16. Pribitkin E, Cowart BJ, Rosenthal MD (2003) Prevalence and causes of severe taste loss in a chemosensory clinic population. Ann Otol Rhinol Laryngol 112:971–978

    Article  Google Scholar 

  17. Hummel T, Krone F, Wolfensberger M, Dorig P, Welge-lussen A (2011) A study about the frequency of taste disorders. J Neurol 258(3):386–392

    Article  Google Scholar 

  18. Hoffman HJ, Cruickshanks KJ, Davis B (2009) Perspectives on population-based epidemiological studies of olfactory and taste impairment. Ann NY Acad Sci 1170:514–530

    Article  Google Scholar 

  19. Morais AAC, Silva MAT, Faintuch J, Vidigal EJ, Costa RA, Lyrio DC et al (2005) Correlation of nutritional status and food intake in hemodialysis patients. Clin (Sao Paulo) 60(3):185–192

    Article  Google Scholar 

  20. Griep M, Niepen P, Sennesael J, Mets T, Massart D, Verbeelen D (1997) nephrology dialysis transplantation odour perception in chronic renal disease. Nephrol Dial Transplant 12:2093–2098

    Article  CAS  Google Scholar 

  21. Armstrong JE, Laing DG, Wilkes FJ, Kainer G (2010) Smell and taste function in children with chronic kidney disease. Paediatr Nephrol 25:1497–1504

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Otorhinolaryngology, University College Hospital, Ibadan, Oyo, Nigeria

    T. Yusuf

  2. Nephrology Unit, Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria

    Y. R. Raji

  3. Department of Physiology/Oral Pathology, College of Medicine, University of Ibadan Ibadan, Ibadan, Oyo, Nigeria

    T. J. Lasisi

  4. Department of Otorhinolaryngology, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria

    A. Daniel, A. J. Fasunla & O. A. Lasisi

  5. Department of Chemical Pathology, University College Hospital, Ibadan, Oyo, Nigeria

    O. T. Bamidele

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  1. T. Yusuf
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  7. O. A. Lasisi
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Correspondence to O. A. Lasisi.

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Yusuf, T., Raji, Y.R., Lasisi, T.J. et al. Effect of Chronic Kidney Disease on Taste Function: A Case Control Study among Nigerian. Indian J Otolaryngol Head Neck Surg 74 (Suppl 3), 5416–5423 (2022). https://doi.org/10.1007/s12070-021-02688-5

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  • DOI: https://doi.org/10.1007/s12070-021-02688-5

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