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Hypertriglyceridemia is a risk factor for treatment failure in patients with peritoneal dialysis-related peritonitis

  • Nephrology - Original Paper
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Abstract

Objective

Disorders of triglycerides (TG) are common in patients with peritoneal dialysis (PD). Hypertriglyceridemia has been demonstrated in various infections. The association between triglycerides and the outcomes of peritoneal dialysis-related peritonitis (PDRP) was investigated in this study.

Methods

We retrospectively investigated patients with PDRP from January 1, 2013 to October 31, 2020. Hypertriglyceridemia was defined as triglycerides ≥ 1.7 mmol/L. PDRP episodes were divided into two groups: hypertriglyceridemia and normal levels of triglycerides. The clinical and laboratory baseline data of the two groups were collected and compared. The association between triglycerides and treatment failure was analyzed by logistic regression analysis.

Results

Ninety episodes in 66 patients were recorded in our center. Hypertriglyceridemia occurred in 38% (34/90) of episodes. Twenty-five episodes were not cured in 90 episodes (27.8%, 25/90). The levels of thrombocytes, high-sensitivity C-reactive protein (hs-CRP), low-density lipoprotein cholesterol (LDL-C) and glycated hemoglobin, were higher in hypertriglyceridemia episodes of PDRP at baseline. The bacterial classification was different between elevated triglyceride group and normal triglyceride group. Adjusted for age, duration of dialysis, residual renal function, diabetes, thrombocytes, hs-CRP, serum albumin, cholesterol, HDL-C, LDL-C, intact parathyroid hormone (iPTH), glycated hemoglobin and spectrum of bacteria, hypertriglyceridemia were associated significantly with treatment failure of PDRP in our study (OR 3.416, 95% CI 1.223–9.540 p < 0.05).

Conclusion

Hypertriglyceridemia at baseline was an independent risk factor for treatment failure of PDRP.

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Acknowledgements

We thank all the doctors and nurses at the peritoneal dialysis center in the Sixth Affiliated Hospital of Sun Yat-Sen University. Thank all patients with PD who participate and provide data for the study.

Funding

This study was supported by the National Natural Science Foundation of China (no. 81500552).

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Author notes

  1. Ya-Juan Huang and Zong-Pei Jiang contributed equally to this work.

Authors and Affiliations

  1. Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China

    Ya-Juan Huang, Zong-Pei Jiang, Ja-Fan Zhou, Xing Zhang, Li-Ping Xiong, Meng-Jun Liang, Hong-Rui Shi, Ning Su & Rui Zhang

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  1. Ya-Juan Huang
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  2. Zong-Pei Jiang
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Correspondence to Ning Su or Rui Zhang.

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Huang, YJ., Jiang, ZP., Zhou, JF. et al. Hypertriglyceridemia is a risk factor for treatment failure in patients with peritoneal dialysis-related peritonitis. Int Urol Nephrol 54, 1583–1589 (2022). https://doi.org/10.1007/s11255-021-03027-x

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  • DOI: https://doi.org/10.1007/s11255-021-03027-x

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