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Synthesis and DNA-binding properties of binuclear platinum complexes with two trans-[Pt(NH3)2Cl]+ units bridged by 4,4′-dipyridyl sulfide or selenide

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Abstract

Two novel dinuclear platinum complexes, {trans-[Pt(NH3)2Cl]2(dpsu)}(NO3)2 (1) and {trans-[Pt(NH3)2Cl]2 (dpse)}(NO3)2 (2) (dpsu = 4,4′-dipyridyl sulfide and dpsu = 4,4′-dipyridyl selenide) have been prepared for use as potential antitumor drugs. Compared to the known monofunctional complex, [cis-Pt(NH3)2Cl(4-methylpyridine)]NO3, (1) exhibits an almost two-fold stronger DNA-binding ability, a result suggesting that (1) may bind bifunctionally to DNA. Kinetic studies show that (1) significantly impedes intercalation of ethidium bromide (EtdBr) into DNA in 0.3 mol dm−3 KNO3 but not in 0.3 mol dm−3 KCl, indicating that the hydrolysis is the first step upon addition of the complex to DNA. Also, the complex may interact with DNA by non-intercalation. Unlike its dinuclear analogs linked by aliphatic diamines, complex (1) does not induce a transition of poly(dG–dC) · poly(dG–dC) from the B form to the Z form. Moreover, complex (1) significantly inhibits the cleavage activity of BamHI endonuclease, but has no effect on that of EcoRI endonuclease. In contrast, its cis analog containing two [cis-Pt(NH3)2Cl]+ units greatly inhibits those of both BamHI and EcoRI, a result suggesting that the two isomers with the same aromatic ligand probably have different properties of DNA binding, and that (1) possibly shows higher DNA-binding selectivity than its cisanalog.

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Authors and Affiliations

  1. College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, PR China

    Guanghua Zhao & Xiaosong Hu

  2. Academy of Military Medical Sciences, Institute of Microbiology and Epidemiology, Beijing, 100071, PR China

    Ping Yu

  3. Department of Chemistry, Nankai University, Tianjin, 300071, PR China

    Huakuan Lin

Authors
  1. Guanghua Zhao
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  2. Xiaosong Hu
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  3. Ping Yu
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  4. Huakuan Lin
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Zhao, G., Hu, X., Yu, P. et al. Synthesis and DNA-binding properties of binuclear platinum complexes with two trans-[Pt(NH3)2Cl]+ units bridged by 4,4′-dipyridyl sulfide or selenide. Transition Metal Chemistry 29, 607–612 (2004). https://doi.org/10.1007/s11243-004-1278-1

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  • DOI: https://doi.org/10.1007/s11243-004-1278-1

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