Skip to main content

Advertisement

SpringerLink
Log in

Platinum Polyoxoniobates Form Adducts with DNA

  • Published:
Russian Journal of Bioorganic Chemistry Aims and scope Submit manuscript

Abstract—

Platinum complexes are among the most commonly prescribed drugs in cancer therapy but show significant toxicity to healthy tissues as a side effect. Platinum polyoxometalates are platinum complexes liganded with cluster anions consisting of oxygen atoms and transition metals. Their properties related to a potential use as anticancer drugs have never been studied. In this paper, we have investigated the effect of platinum (IV) polyoxoniobate of the [Nb6O19{Pt(OH)2}]2 structure containing two platinum centers and two polynuclear Lindqvist type anions on the activity of a number of DNA polymerases belonging to different families (Klenow fragment of Escherichia coli DNA polymerase I, bacteriophage RB69 DNA polymerase, human DNA polymerases β and κ, DNA polymerase IV from Sulfolobus solfataricus). On its own, platinum polyoxoniobate did not act as an inhibitor of DNA polymerases, but was capable of forming adducts with DNA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.

Similar content being viewed by others

REFERENCES

  1. Kelland, L., Nat. Rev. Cancer, 2007, vol. 7, pp. 573–584.

    Article  CAS  Google Scholar 

  2. Florea, A.-M. and Büsselberg, D., Cancers, 2011, vol. 3, pp. 1351–1371.

    Article  CAS  Google Scholar 

  3. Lawley, P.D. and Phillips, D.H., Mutat. Res., 1996, vol. 355, pp. 13–40.

    Article  Google Scholar 

  4. Jamieson, E.R. and Lippard, S.J., Chem. Rev., 1999, vol. 99, pp. 2467–2498.

    Article  CAS  Google Scholar 

  5. Wang, D. and Lippard, S.J., Nat. Rev. Drug Discov., 2005, vol. 4, pp. 307–320.

    Article  CAS  Google Scholar 

  6. Dasari, S. and Tchounwou, P.B., Eur. J. Pharmacol., 2014, vol. 740, pp. 364–378.

    Article  CAS  Google Scholar 

  7. Wheate, N.J., Walker, S., Craig, G.E., and Oun, R., Dalton Trans., 2010, vol. 39, pp. 8113–8127.

    Article  CAS  Google Scholar 

  8. Apps, M.G., Choi, E.H.Y., and Wheate, N.J., Endocr. Relat. Cancer, 2015, vol. 22, pp. R219–R233.

    Article  CAS  Google Scholar 

  9. Hu, X., Li, F., Noor, N., and Ling, D., Sci. Bull., 2017, vol. 62, pp. 589–596.

    Article  CAS  Google Scholar 

  10. Li, X., Liu, Y., and Tian, H., Bioinorg. Chem. Appl., 2018, vol. 2018, p. 8 276 139.

    Article  Google Scholar 

  11. Shigeta, S., Mori, S., Yamase, T., Yamamoto, N., and Yamamoto, N., Biomed. Pharmacother., 2006, vol. 60, pp. 211–219.

    Article  CAS  Google Scholar 

  12. Yanagie, H., Ogata, A., Mitsui, S., Hisa, T., Yamase, T., and Eriguchi, M., Biomed. Pharmacother., 2006, vol. 60, pp. 349–352.

    Article  CAS  Google Scholar 

  13. Stephan, H., Kubeil, M., Emmerling, F., and Müller, C.E., Eur. J. Inorg. Chem., 2013, vol. 2013, pp. 1585–1594.

    Article  CAS  Google Scholar 

  14. Wang, S., Sun, W., Hu, Q., Yan, H., and Zeng, Y., Bioorg. Med. Chem. Lett., 2017, vol. 27, pp. 2357–2359.

    Article  CAS  Google Scholar 

  15. Bijelic, A., Aureliano, M., and Rompel, A., Chem. Commun., 2018, vol. 54, pp. 1153–1169.

    Article  CAS  Google Scholar 

  16. Bijelic, A., Aureliano, M., and Rompel, A., Angew. Chem., Int. Ed. Engl., 2019, vol. 58, pp. 2980–2999.

    Article  CAS  Google Scholar 

  17. Sun, T., Cui, W., Yan, M., Qin, G., Guo, W., Gu, H., Liu, S., and Wu, Q., Adv. Mater., 2016, vol. 28, pp. 7397–7404.

    Article  CAS  Google Scholar 

  18. Abramov, P.A., Vicent, C., Kompankov, N.B., Gushchin, A.L., and Sokolov, M.N., Chem. Commun., 2015, vol. 51, pp. 4021–4023.

    Article  CAS  Google Scholar 

  19. Inouye, Y., Tokutake, Y., Kunihara, J., Yoshida, T., Yamase, T., Nakata, A., and Nakamura, S., Chem. Pharm. Bull., 1992, vol. 40, pp. 805–807.

    Article  CAS  Google Scholar 

  20. Sarafianos, S.G., Kortz, U., Pope, M.T., and Modak, M.J., Biochem. J., 1996, vol. 319, pp. 619–626.

    Article  CAS  Google Scholar 

  21. Schoeberl, C., Boehner, R., Krebs, B., Mueller, C., and Barnekow, A., Int. J. Oncol., 1998, vol. 12, pp. 153–159.

    CAS  PubMed  Google Scholar 

  22. Steitz, T.A., J. Biol. Chem., 1999, vol. 274, pp. 17 395–17 398.

    Article  Google Scholar 

  23. Torres, M.C., Varaprasad, C.V., Johnson, F., and Iden, C.R., Carcinogenesis, 1999, vol. 20, pp. 167–172.

    Article  CAS  Google Scholar 

  24. Wang, X., Liu, J., Li, J., Yang, Y., Liu, J., Li, B., and Pope, M.T., J. Inorg. Biochem., 2003, vol. 94, pp. 279–284.

    Article  CAS  Google Scholar 

  25. Dianat, S., Bordbar, A.K., Tangestaninejad, S., Yadollahi, B., Zarkesh-Esfahani, S.H., and Habibi, P., J. Photochem. Photobiol., vol. 124, pp. 27–33.

  26. Ohashi, E., Ogi, T., Kusumoto, R., Iwai, S., Masutani, C., Hanaoka, F., and Ohmori, H., Genes Dev., 2000, vol. 14, pp. 1589–1594.

    CAS  PubMed  PubMed Central  Google Scholar 

  27. Freisinger, E., Grollman, A.P., Miller, H., and Kisker, C., EMBO J., 2004, vol. 23, pp. 1494–1505.

    Article  CAS  Google Scholar 

  28. Sambrook, J. and Russell, D.W., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press, 2001.

    Google Scholar 

Download references

Funding

This study was supported by the Russian Foundation for Basic Research (project no. 19-44-543011-r_mol_a), Novosibirsk region, and partially by a project of Basic Funding from the Program for Fundamental Scientific Research of State Science Academies for 2013–2020 No. АААА-А17-117020210023-1 (synthesis of oligonucleotides, extraction of a part of proteins) and the Ministry of Higher Education and Science of the Russian Federation (project 6.5773.2017/VU, data analysis).

Author information

Authors and Affiliations

  1. Institute of Chemical Biology and Fundamental Medicine, 630090, Novosibirsk, Russia

    A. V. Yudkina, I. R. Grin & D. O. Zharkov

  2. Novosibirsk State University, 630090, Novosibirsk, Russia

    A. V. Yudkina, I. R. Grin & D. O. Zharkov

  3. Nikolaev Institute of Inorganic Chemistry, 630090, Novosibirsk, Russia

    M. N. Sokolov & P. A. Abramov

Authors
  1. A. V. Yudkina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. N. Sokolov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. A. Abramov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. I. R. Grin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. D. O. Zharkov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to D. O. Zharkov.

Ethics declarations

This article does not contain any studies involving animals or human participants performed by any of the authors.

Conflict of Interests

Authors declare that they have no conflicts of interests.

Additional information

Translated by M. Novikova

Abbreviations: DTT, dithiothreitol; EDTA, ethylenediaminetetraacetic acid; KF, Klenow fragment of Escherichia coli DNA polymerase I; ODN, oligodeoxyribonucleotide; Pt-PON, platinum polyoxoniobate.

Corresponding author: phone: +7 (383) 363-51-87; fax: +7 (383) 363-51-53; e-mail: dzharkov@niboch.nsc.ru.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yudkina, A., Sokolov, M., Abramov, P. et al. Platinum Polyoxoniobates Form Adducts with DNA. Russ J Bioorg Chem 45, 641–646 (2019). https://doi.org/10.1134/S1068162019060414

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1068162019060414

Keywords:

Search

Navigation