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Synthesis of 5-oxo-1-(5-R-1,3,4-thiadiazol-2-yl)pyrrolidine-3-carboxylic acids

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Abstract

A series of new heterocyclic ensembles, derivatives of 5-oxo-1-(1,3,4-thiadiazol-2-yl)-pyrrolidine-3-carboxylic acid, was synthesized by heating 5-substituted 1,3,4-thiadiazol-2-amines and itaconic acid under solvent-free conditions or with the addition of acetic acid at 140–150 °C. The resulting acids can be used as building blocks in the synthesis of new potentially biologically active heterocyclic compounds.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    S. A. Serkov, N. V. Sigay, N. N. Kostikova, N. G. Kolotyrkina & G. A. Gazieva

  2. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 ul. Miklukho-Maklaya, 117997, Moscow, Russian Federation

    A. P. Tyurin

Authors
  1. S. A. Serkov
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  2. N. V. Sigay
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  3. N. N. Kostikova
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  4. A. P. Tyurin
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  5. N. G. Kolotyrkina
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  6. G. A. Gazieva
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Corresponding author

Correspondence to G. A. Gazieva.

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No human or animal subjects were used in this research.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 72, No. 8, pp. 1837–1843, August, 2023.

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Serkov, S.A., Sigay, N.V., Kostikova, N.N. et al. Synthesis of 5-oxo-1-(5-R-1,3,4-thiadiazol-2-yl)pyrrolidine-3-carboxylic acids. Russ Chem Bull 72, 1837–1843 (2023). https://doi.org/10.1007/s11172-023-3966-z

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  • DOI: https://doi.org/10.1007/s11172-023-3966-z

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