Abstract
A one-pot condensation of 5-oxopyrrolidine-3-carboxylic acids, carbonyldiimidazole, and benzamidoximes leads to the formation of the novel 4-(1,2,4-oxadiazol-5-yl)pyrrolidin-2-one bicyclic systems, the structures of which have been confirmed by IR and 1H NMR methods and by liquid chromato-mass spectrometry. The results of a PASS prediction of the biological activity of the synthesized compounds are presented.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 758–764, May, 2008.
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Kharchenko, Y.V., Detistov, O.S. & Orlov, V.D. Polycyclic systems containing 1,2,4-oxadiazole ring 2. 4-(1,2,4-Oxadiazol-5-yl)pyrrolidin-2-ones: Synthesis and prediction of biological activity. Chem Heterocycl Comp 44, 600–605 (2008). https://doi.org/10.1007/s10593-008-0080-y
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DOI: https://doi.org/10.1007/s10593-008-0080-y