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Synthesis of S-substituted 5-sulfonylmethyl(ethyl)-1,3,4-thiadiazol-2-amines

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Chemistry of Heterocyclic Compounds Aims and scope

A series of 1,3,4-thiadiazol-2-amines with substituents containing SO2 group located at position 5 were obtained in good yields (63–81%) by cyclization of aryl(benzyl)sulfonylacetic or aryl(benzyl)sulfonylpropionic acids with thiosemicarbazide in refluxing POCl3.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave, Moscow, 119991, Russia

    Sergei A. Serkov, Natalya V. Sigay, Natalya N. Kostikova, Aleksander E. Fedorov & Galina A. Gazieva

  2. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St, Moscow, 117997, Russia

    Anton P. Tyurin

Authors
  1. Sergei A. Serkov
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  2. Natalya V. Sigay
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  3. Natalya N. Kostikova
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  4. Aleksander E. Fedorov
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  5. Anton P. Tyurin
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  6. Galina A. Gazieva
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Correspondence to Galina A. Gazieva.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2022, 58(10), 514–517

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Serkov, S.A., Sigay, N.V., Kostikova, N.N. et al. Synthesis of S-substituted 5-sulfonylmethyl(ethyl)-1,3,4-thiadiazol-2-amines. Chem Heterocycl Comp 58, 514–517 (2022). https://doi.org/10.1007/s10593-022-03121-7

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  • DOI: https://doi.org/10.1007/s10593-022-03121-7

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