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Synthesis and physiological activity of new imidazolidin-2-one bis-heterocyclic derivatives

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Russian Chemical Bulletin Aims and scope

Abstract

Amidoalkylation of indole, oxindole, pyrazolone, and pyrazole derivatives using 5-hydroxy-1-phenylimidazolidin-2-one afforded a number of new unsymmetric bis-heterocyclic compounds with a direct C-C bond. The 3-(2-oxoimidazolidin-5-yl)indole derivatives were found to possess anti-inflammatory activity and relatively low cytotoxicity.

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Authors and Affiliations

  1. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 119991, Moscow, Russian Federation

    K. A. Kochetkov, O. N. Gorunova & N. A. Bystrova

  2. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 ul. Miklukho-Maklaya, 117997, Moscow, Russian Federation

    P. V. Dudina & M. G. Akimov

Authors
  1. K. A. Kochetkov
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  2. O. N. Gorunova
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  3. N. A. Bystrova
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  4. P. V. Dudina
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  5. M. G. Akimov
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Corresponding author

Correspondence to K. A. Kochetkov.

Additional information

The work was carried out in the framework of the Russian state assignment of the Ministry of Science and Higher Education of the Russian Federation using the equipment of the Center for Molecular Structure Studies at the A. N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences (Project No. 075-00697-22-00).

No human or animal subjects were used in this research.

The authors declare no competing interests.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2395–2403, November, 2022.

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Kochetkov, K.A., Gorunova, O.N., Bystrova, N.A. et al. Synthesis and physiological activity of new imidazolidin-2-one bis-heterocyclic derivatives. Russ Chem Bull 71, 2395–2403 (2022). https://doi.org/10.1007/s11172-022-3667-z

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  • DOI: https://doi.org/10.1007/s11172-022-3667-z

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