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Regulation of DAPK1 by Natural Products: An Important Target in Treatment of Stroke

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Abstract

Stroke is a sudden neurological disorder that occurs due to impaired blood flow to an area of the brain. Stroke can be caused by the blockage or rupture of a blood vessel in the brain, called ischemic stroke and hemorrhagic stroke, respectively. Stroke is more common in men than women. Atrial fibrillation, hypertension, kidney disease, high cholesterol and lipids, genetic predisposition, inactivity, poor nutrition, diabetes mellitus, family history and smoking are factors that increase the risk of stroke. Restoring blood flow by repositioning blocked arteries using thrombolytic agents or endovascular therapy are the most effective treatments for stroke. However, restoring circulation after thrombolysis can cause fatal edema or intracranial hemorrhage, and worsen brain damage in a process known as ischemia–reperfusion injury. Therefore, there is a pressing need to find and develop more effective treatments for stroke. In the past, the first choice of treatment was based on natural compounds. Natural compounds are able to reduce the symptoms and reduce various diseases including stroke that attract the attention of the pharmaceutical industry. Nowadays, as a result of the numerous studies carried out in the field of herbal medicine, many useful and valuable effects of plants have been identified. The death-associated protein kinase (DAPK) family is one of the vital families of serine/threonine kinases involved in the regulation of some biological functions in human cells. DAPK1 is the most studied kinase within the DAPKs family as it is involved in neuronal and recovery processes. Dysregulation of DAPK1 in the brain is involved in the developing neurological diseases such as stroke. Natural products can function in a variety of ways, including reducing cerebral edema, reducing brain endothelial cell death, and inhibiting TNFα and interleukin-1β (IL-1β) through regulating the DAPK1 signal against stroke. Due to the role of DAPK1 in neurological disorders, the aim of this article was to investigate the role of DAPK1 in stroke and its modulation by natural compounds.

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Authors and Affiliations

  1. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Tayebeh Noori & Samira Shirooie

  2. Research Group on Community Nutrition and Oxidative Stress (NUCOX) and Health Research Institute of Balearic Islands (IdISBa), University of Balearic Islands, 07122, Palma de Mallorca, Balearic Islands, Spain

    Antoni Sureda

  3. CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain

    Antoni Sureda

  4. Instituto de Investigación y Postgrado, Facultad de Ciencias de la Salud, Universidad Central de Chile, Santiago, Chile

    Eduardo Sobarzo-Sanchez & Marianela Saldías

  5. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Ahmad Reza Dehpour

  6. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Ahmad Reza Dehpour

  7. Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330, Ankara, Turkey

    Esra Küpeli Akkol

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SS and TN contributed to the conception of the manuscript. SS, TN, AS and AD drafted the manuscript. All of the authors revised the manuscript and gave the final approval.

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Noori, T., Shirooie, S., Sureda, A. et al. Regulation of DAPK1 by Natural Products: An Important Target in Treatment of Stroke. Neurochem Res 47, 2142–2157 (2022). https://doi.org/10.1007/s11064-022-03628-7

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