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The study of the mechanism of non-coding RNA regulation of programmed cell death in diabetic cardiomyopathy

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Abstract

Diabetic cardiomyopathy (DCM) represents a distinct myocardial disorder elicited by diabetes mellitus, characterized by aberrations in myocardial function and structural integrity. This pathological condition predominantly manifests in individuals with diabetes who do not have concurrent coronary artery disease or hypertension. An escalating body of scientific evidence substantiates the pivotal role of programmed cell death (PCD)—encompassing apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis—in the pathogenic progression of DCM, thereby emerging as a prospective therapeutic target. Additionally, numerous non-coding RNAs (ncRNAs) have been empirically verified to modulate the biological processes underlying programmed cell death, consequently influencing the evolution of DCM. This review systematically encapsulates prevalent types of PCD manifest in DCM as well as nascent discoveries regarding the regulatory influence of ncRNAs on programmed cell death in the pathogenesis of DCM, with the aim of furnishing novel insights for the furtherance of research in PCD-associated disorders relevant to DCM.

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Authors and Affiliations

  1. Affiliated Hospital of Shandong University of Traditional Chinese Medicine Cardiovascular Department Cardiovascular Disease Research, Jinan, 250014, Shandong, China

    Bingrui Zhang, Jingwen Zhang & Cong Cong

  2. Tai’an Special Care Hospital Clinical Laboratory Medical Laboratory Direction, Tai’an, 271000, Shandong, China

    Hua Wu

  3. Tai’an Hospital of Chinese Medicine Cardiovascular Department Cardiovascular Disease Research, No.216, Yingxuan Street, Tai’an, 271000, Shandong, China

    Lin Zhang

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  1. Bingrui Zhang
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  3. Jingwen Zhang
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  4. Cong Cong
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ZBR contributed to the conception and design of this manuscript. ZL has critically revised the entire manuscript. WH, ZJW, and CC are responsible for manuscript structure and English grammar. All authors participated in manuscript revision, read and approved the submitted version. All authors revised and approved the final manuscript. “The author(s) read and approved the final manuscript.”

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Zhang, B., Wu, H., Zhang, J. et al. The study of the mechanism of non-coding RNA regulation of programmed cell death in diabetic cardiomyopathy. Mol Cell Biochem (2024). https://doi.org/10.1007/s11010-023-04909-7

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