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Investigation of the interaction between acidic, basic, neutral, and zwitterionic drugs with poly-L-lactic acid by thermal and analytical methods

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Abstract

This project investigated the interaction between poly-L-lactic acid (PLLA) and several therapeutic agents. Low percentage crystallinity PLLA (melt-pressed, molded and drawn) was studied. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) were used to characterize the crystallinity and thermal properties in a thermal cycling process. Repeatable melting and crystallization events were observed. The thermal properties of a drug-polymer combination using PLLA and an acidic, basic, neutral and zwitterionic material were investigated. A sufficient quantity of the drug must be present in the polymer to be observed thermally. Release of atropine sulfate from a PLLA tablet showed a two-phase process.

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Authors and Affiliations

  1. College of Pharmacy, Pharmacy Practice Department, The University of Toledo, Toledo, OH, 43606, USA

    R. G. Milallos, K. Alexander & A. Riga

Authors
  1. R. G. Milallos
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  2. K. Alexander
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  3. A. Riga
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Correspondence to A. Riga.

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Milallos, R.G., Alexander, K. & Riga, A. Investigation of the interaction between acidic, basic, neutral, and zwitterionic drugs with poly-L-lactic acid by thermal and analytical methods. J Therm Anal Calorim 93, 289–294 (2008). https://doi.org/10.1007/s10973-007-8836-7

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  • DOI: https://doi.org/10.1007/s10973-007-8836-7

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