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Interpolyelectrolyte Complexes of Eudragit® EPO with Hypromellose Acetate Succinate and Eudragit® EPO with Hypromellose Phthalate as Potential Carriers for Oral Controlled Drug Delivery

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Abstract

The objective of this study was to compare a novel controlled release tablet formulation based on interpolyelectrolyte complex (PEC). Interpolymer interactions between the countercharged polymers like Eudragit® EPO (polycation) and hypromellose acetate succinate (polyanion) and Eudragit® EPO and hypromellose phthalate (polyanion) were investigated with a view to their use in per oral controlled release drug delivery systems. The formation of inter-macromolecular ionic bonds between cationic polymer and anionic polymer was investigated using Fourier transform infrared (FT-IR) spectroscopy and differential scanning calorimetry. The FT-IR spectra of the tested polymeric matrices are characterized by visible changes in the observed IR region indicating the interaction between chains of two oppositely charged copolymers. The performance of the in situ formed PEC as a matrix for controlled release of drugs was evaluated, using acetaminophen as a model drug. The dissolution data of these matrices were fitted to different dissolution models. It was found that drug release followed zero-order kinetics and was controlled by the superposition of the diffusion and erosion. These profiles could be controlled by conveniently modifying the proportion of the polymer ratio, polymer type, and polymer concentration the in the tablets.

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Acknowledgments

The authors are grateful to Mylan laboratories Limited, Hyderabad, India, for the generous gift samples of acetaminophen and excipients. The authors wish to thank Dr. Abhijit Deshmukh for supporting the project.

Conflict of Interest

The authors report no conflict of interest.

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Authors and Affiliations

  1. Department of Pharmacy, Jawaharlal Nehru Technological University Hyderabad, Hyderabad, Andhra Pradesh, India

    Balamurugan Jeganathan

  2. Department of Pharmaceutics, Vijaya College of Pharmacy, Munganoor (v), Hayathnagar (M), Hyderabad, Andhra Pradesh, 501511, India

    Vijayalakshmi Prakya

  3. Plot No.34A, ANRICH Industrial Estate, Bollaram, Jinnaram (Mandal), Medak Dist, 502325, India

    Balamurugan Jeganathan

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  1. Balamurugan Jeganathan
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  2. Vijayalakshmi Prakya
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Correspondence to Balamurugan Jeganathan.

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Jeganathan, B., Prakya, V. Interpolyelectrolyte Complexes of Eudragit® EPO with Hypromellose Acetate Succinate and Eudragit® EPO with Hypromellose Phthalate as Potential Carriers for Oral Controlled Drug Delivery. AAPS PharmSciTech 16, 878–888 (2015). https://doi.org/10.1208/s12249-014-0252-2

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  • DOI: https://doi.org/10.1208/s12249-014-0252-2

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