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Additive manufacturing of bio-based hydrogel composites: recent advances

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Abstract

Additive manufacturing (aka 3D printing) has excellent potential for developing advanced materials and technologies, and it’s extensively been explored in several areas such as tissue engineering, cancer research, multifunctional devices, surgical preparation, and printable electronics than a decade. This review highlights the emerging advances in additive manufacturing-enabled hydrogels and their composites. The mechanical features of 3D printed hydrogels that show strong tissue adaptability, and the hydrogels that incorporate water within moist states, demonstrate their potential for a multitude of applications, for example, wound dressings. Recently, the 3D printing of bio-based hydrogels and other polymers has been considered a viable path toward ultimate regenerative treatment. Here, we provide an overview of (i) polymer additive manufacturing processes, (ii) different polysaccharides-based hydrogels, and (iii) the different applications of bio-based hydrogels in 3D printing. Lastly, we conclude our discussion by highlighting the future research directions.

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Fig. 1

Reprinted with permission from Ref. [33]

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Reprinted with permission from Ref. [85]

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Reprinted with permission from Ref. [87]

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Reprinted with permission from Ref. [91]

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Reprinted with permission from Ref. [94]

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Reprinted with permission from Ref. [110]

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Acknowledgements

The authors acknowledge the support from the Department of Chemistry and Research & Development Cell of Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India. Walaa Fahad Alsanie would also like to acknowledge the Taif University TURSP program (TURSP-HC2022/5) for funding. Adriana Kovalcik acknowledges funding from the Brno University of Technology through grant FCH-S-22-7909. Vijay Kumar Thakur would also like to thank the research support provided by the UKRI via Grant No. EP/T024607/1, Royal Academy of Engineering (IAPP18-19\295), and SFC (UIF funding).

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Authors and Affiliations

  1. Department of Chemistry, M.M. Engineering College, Maharishi Markandeshwar (Deemed to be University), 133207, Mullana-Ambala, Haryana, India

    Samarjeet Singh Siwal & Kirti Mishra

  2. Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), 133207, Mullana- Ambala, Haryana, India

    Adesh Kumar Saini

  3. Department of Clinical Laboratories Sciences, The Faculty of Applied Medical Sciences, Taif University, P.O. Box 11099, 21944, Taif, Saudi Arabia

    Walaa Fahad Alsanie

  4. Institute of Food Science and Biotechnology, Faculty of Chemistry, Brno University of Technology, Purkynova 118, 612 00, Brno, Czech Republic

    Adriana Kovalcik

  5. Biorefining and Advanced Materials Research Center, Scotland’s Rural College (SRUC), Kings Buildings, West Mains Road, EH9 3JG, Edinburgh, UK

    Vijay Kumar Thakur

  6. School of Engineering, University of Petroleum & Energy Studies (UPES), 248007, Dehradun, Uttarakhand, India

    Vijay Kumar Thakur

  7. Centre for Research & Development, Chandigarh University, 140413, Mohali, Punjab, India

    Vijay Kumar Thakur

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  1. Samarjeet Singh Siwal
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Siwal, S.S., Mishra, K., Saini, A.K. et al. Additive manufacturing of bio-based hydrogel composites: recent advances. J Polym Environ 30, 4501–4516 (2022). https://doi.org/10.1007/s10924-022-02516-z

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