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Response Surface Methodology Optimization of Mono-dispersed MgO Nanoparticles Fabricated by Ultrasonic-Assisted Sol–Gel Method for Outstanding Antimicrobial and Antibiofilm Activities

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Abstract

Magnesium oxide (MgO) nanoparticles are one of the highly significant compounds in construction. The novelty concentrated on using sol–gel technique coupled with ultrasonication for synthesis of MgO nanoparticles to prevent the agglomeration and its effect on the size was investigated. The synthesized samples were characterized by TGA, DSC, XRD, FTIR, SEM, EDX mapping, DLS, and HRTEM. Antimicrobial and antibiofilm activities of MgO nanoparticles were investigated against multidrug-resistant microbes causing-urinary tract infection (UTI). TGA, XRD, and FTIR characterization were used to identify the calcination temperature, characterization peaks, and functional groups of MgO nanoparticles, respectively. DLS technique confirmed the particle size distribution which found to be 21.04 nm. HRTEM and SEM/EDX mapping showed that MgO nanoparticles are pure, spherical and the average particle size is 19.2 nm. MgO nanoparticles showed a promising antimicrobial effect against all UTI-causing pathogens. It showed a prominent antimicrobial capability against Staphylococcus aureus, Escherichia coli and Candida albicans by 19.3 mm, 16.1 mm and 15.2 mm ZOI, respectively. Additionally, they showed improved biofilm inhibition as 95.65%, 84.23%, and 76.85% against C. albicans, E. coli and S. aureus, respectively. Therefore, due to these outstanding properties, this study could give insights for solving serious industrial, pharmaceutical and medical challenges throughout the utilization of new nanoparticle-based approach.

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Acknowledgements

All the authors want to acknowledge the support of Department of Chemical Engineering, Faculty of Engineering and Sciences in the experiments and completion of this manuscript. The authors would like to thank the PI of Nanotechnology Research Unit (Prof. Dr. Ahmed I. El-Batal), Drug Microbiology Lab., Drug Radiation Research Department, NCRRT, Egypt, for financing and supporting this study under the project “Nutraceuticals and Functional Foods Production by using Nano/Biotechnological and Irradiation Processes”. Also, the authors would like to thank Director of Research, Nile University, Egypt and Prof. Mohamed Gobara (Military Technical College, Egyptian Armed Forces), and Zeiss microscope team in Cairo, Egypt for their invaluable advice during this study.

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Authors and Affiliations

  1. Department of Chemical Engineering, Faculty of Engineering and Science, Curtin University, CDT 250, 98009, Miri, Sarawak, Malaysia

    Chiew Wee Wong, Yen San Chan & Jaison Jeevanandam

  2. Department of Nanotechnology, Bharath Institute of Higher Education and Research, Bharath University, BIHER Research Park, 173 Agharam Road, Selaiyur, Chennai, Tamil Nadu, 600073, India

    Kaushik Pal

  3. CNRS, Institut Européen des Membranes (IEMM, ENSCM UM CNRS UMR5635) Place Eugèn eBataillon, 34095, Montpellier Cedex 5, France

    Mikhael Bechelany

  4. Center for Nanotechnology (CNT), School of Engineering and Applied Sciences, Nile University, Sheikh Zayed, Giza, 16453, Egypt

    M. Abd Elkodous

  5. Drug Microbiology Lab, Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt

    Gharieb S. El-Sayyad

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  1. Chiew Wee Wong
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  2. Yen San Chan
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  3. Jaison Jeevanandam
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  4. Kaushik Pal
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  6. M. Abd Elkodous
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  7. Gharieb S. El-Sayyad
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Correspondence to Kaushik Pal or Gharieb S. El-Sayyad.

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Wong, C.W., Chan, Y.S., Jeevanandam, J. et al. Response Surface Methodology Optimization of Mono-dispersed MgO Nanoparticles Fabricated by Ultrasonic-Assisted Sol–Gel Method for Outstanding Antimicrobial and Antibiofilm Activities. J Clust Sci 31, 367–389 (2020). https://doi.org/10.1007/s10876-019-01651-3

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