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One-Pot Green Synthesis of Hematite (α-Fe2O3) Nanoparticles by Ultrasonic Irradiation and Their In Vitro Cytotoxicity on Human Keratinocytes CRL-2310

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Abstract

Greener and ecofriendly approaches to the synthesis of hematite (α-Fe2O3) nanoparticles are important for various biomedical applications. The authors describe on a facile, one-pot method for synthesizing hematite nanoparticles (HNPs) using ultrasonic irradiation of iron(III) oxide solution containing the aqueous root extract of Arisaema amurense, which was used as both reducing and stabilizing agents. The synthesized HNPs were characterized by X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, thermogravimetric analysis (TGA), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), transmission electron microscopy (TEM), and vibrating sample magnetometry (VSM). FT-IR analysis indicated the presence of stabilizing groups such as hydroxyl (–OH), C–O, and amide (–NH–) on the surfaces of HNPs. TEM analysis revealed the formation of near spherical HNPs of average size 24.55 ± 6.9 nm. VSM confirmed the ferromagnetic nature of the HNPs with a saturation magnetization (Ms) at 1.25 emu/g and remanent magnetization (Mr) at 0.50 emu/g at 301 K. The electrochemical behavior of glassy carbon (GC)/HNPs electrode was studied using cyclic voltammetry (CV). MTT assays of the HNPs exhibited in vitro concentration-dependent cytotoxicity to human keratinocytes CRL-2310, which indicated the synthesized HNPs are compatible with requirements for in vivo biomedical applications at lower concentrations.

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Acknowledgment

This study was supported by the 2016 Yeungnam University Research Grant.

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Authors and Affiliations

  1. School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongbuk, 38541, Republic of Korea

    Kannan Badri Narayanan & Sung Soo Han

  2. Department of Nano, Medical & Polymer Materials, College of Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongbuk, 38541, Republic of Korea

    Kannan Badri Narayanan & Sung Soo Han

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  1. Kannan Badri Narayanan
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  2. Sung Soo Han
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Correspondence to Sung Soo Han.

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Narayanan, K.B., Han, S.S. One-Pot Green Synthesis of Hematite (α-Fe2O3) Nanoparticles by Ultrasonic Irradiation and Their In Vitro Cytotoxicity on Human Keratinocytes CRL-2310. J Clust Sci 27, 1763–1775 (2016). https://doi.org/10.1007/s10876-016-1040-9

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