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Sensitive determination of ascorbic acid, dopamine and uric acid by glassy carbon electrodes modified with β-cyclodextrin and graphene oxide

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Abstract

In this paper, an ultra-sensitive glassy carbon electrode modified with β-cyclodextrin and graphene oxide (β-CD-GO/GCE) has been prepared for the detection of biomolecules [ascorbic acid (AA), dopamine (DA) and uric acid (UA)] in aqueous solution at μM level. The three biomolecules (AA, DA and UA) can be simultaneously detected by the modified electrodes, and the electrical signals corresponding to various biomolecules can be identified clearly in cyclic voltammetry and differential pulse voltammetry curves. The simultaneous detection limits of AA, DA, UA were 4.58, 1.56, 1.27 μM, respectively. This ultra-sensitivity should be attributed to the formation of host–guest complexes between β-CD and the biomolecules. Furthermore, the anti-interference experiments indicated the β-CD-GO/GCE exhibited satisfactory selective recognition performance.

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The authors declare that all data supporting the findings of this study are available within the article.

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Authors and Affiliations

  1. Hubei Key Laboratory of Plasma Chemical and Advanced Materials, Key Laboratory for Green Chemical Process of Ministry of Education, School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan, 430205, China

    Qiwen Guo, Xinpeng Men, Zhe Chen, Geming Wang, Hongyang Zhao & Zhidong Lin

  2. School of Medicine, Wuhan University of Science and Technology, Wuhan, 430081, China

    Siyuan Liu

  3. School of Electrical and Inforfmation Engineering, Wuhan Institute of Technology, Wuhan, 430205, China

    Lei Yao

  4. Department of Obstetrics and Gynecology, Wuhan General Hospital of the People’s Liberation Army, Wuhan, 430070, China

    Qian Wu

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  1. Qiwen Guo
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Contributions

All authors contributed to the study conception and design. QG: Material preparation was performed. QG, SL and XM: Data collection and analysis were performed. QG: The first draft of the manuscript was written and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Zhe Chen or Qian Wu.

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Guo, Q., Liu, S., Men, X. et al. Sensitive determination of ascorbic acid, dopamine and uric acid by glassy carbon electrodes modified with β-cyclodextrin and graphene oxide. J Mater Sci: Mater Electron 33, 23566–23579 (2022). https://doi.org/10.1007/s10854-022-09116-6

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