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A covalent organic polymer–TiO2/Ti3C2 heterostructure as nonenzymatic biosensor for voltammetric detection of dopamine and uric acid

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Abstract

Heterostructures have potential to blend the advantages of each material, even exhibiting the evolutionary performance due to synergistic effects. Herein, covalent organic polymers (NUF) are integrated with a TiO2/Ti3C2Tx nanocomposite (TiO2/TiCT) to form TiO2/TiCT-NUF heterojunctions as an enlarged nonenzymatic biosensor for dopamine (DA) and uric acid (UA). Detection is performed by differential pulse voltammetry (DPV). The TiO2/TiCT/NUF exhibits high sensing activity with low detection limits of 0.2 and 0.18 nM (S/N = 3) in the concentration ranges from 0.002 to 100 μM and 0.001 to 60 μM for simultaneous determination of DA and UA, respectively. In addition, the TiO2/TiCT/NUF provides good selectivity and reproducibility for DA and UA detection in urine and serum samples with recoveries of 98.4 to 100.9%. The proposed heterojunctions manifest an intriguing potential as a candidate of an electrochemical sensor for sole and simultaneous detection of DA and UA.

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Funding

This study received financial support from the National Natural Science Foundation of China (Nos. 21771047, 21403048, 21401147 and 21571045), University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province (No. UNPYSCT-2017183), Harbin Science and Technology Bureau (2016RAQXJ161), and PhD Research Startup Program of Harbin Normal University, China (No. XKB201310).

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Authors and Affiliations

  1. Key Laboratory of Photochemical Biomaterials and Energy Storage Materials, Heilongjiang Province and College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, 150025, People’s Republic of China

    Xing Lu, Wei Guo, Feng Zhang & Fengyu Qu

  2. Modern Experiment Center, Harbin Normal University, Harbin, 150025, People’s Republic of China

    Songnan Li

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  1. Xing Lu
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  2. Songnan Li
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  3. Wei Guo
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  4. Feng Zhang
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Correspondence to Feng Zhang or Fengyu Qu.

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Lu, X., Li, S., Guo, W. et al. A covalent organic polymer–TiO2/Ti3C2 heterostructure as nonenzymatic biosensor for voltammetric detection of dopamine and uric acid. Microchim Acta 188, 95 (2021). https://doi.org/10.1007/s00604-021-04755-8

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