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Advancing strategies towards the development of tissue engineering scaffolds: a review

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Abstract

The field of tissue engineering involves various methodologies employed to improve or replace biological tissues with extracellular matrices (ECMs). Significant progress has been made, particularly in the fabrication of three-dimensional (3D) scaffolds for replacing damaged tissues or organs. The current review broadly focuses on the various research works carried out involving the use of biomaterials (biopolymers, bio-ceramics and dopants) in this area. A detailed discussion on several scaffold-making modern technologies has also been provided, along with a demonstration of different characterization techniques. Though a number of review papers have been published on biomaterials and fabrication techniques, a very small number focuses on the clinical trials carried out and the commercialization of scaffolds in the biomedical field. Thus, a critical analysis and detailed discussion of some of the clinical trials, market growth, and future demands have been presented in this paper.

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Acknowledgements

The authors gratefully acknowledge financial support from Department of Chemicals and Petrochemicals, Ministry of Chemicals and Fertilizers (DCPC), Government of India [F:No 25012/01/2020-PC-II (FTS: 16020)]. We would like to thank the Laboratory of Advanced Research in Polymeric Materials for the completion of manuscript.

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  1. Laboratory for Advanced Research in Polymeric Materials (LARPM), School for Advanced Research in Polymers (SARP), Central Institute of Petrochemicals Engineering & Technology (CIPET), Patia, Bhubaneswar, 751024, Odisha, India

    Ipsita Pattanayak, Y. Alex & Smita Mohanty

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All authors contributed to the study, concepts, and design. The first draft of the review article was written by IP. The part containing clinical trials was written by YA. The manuscript was reviewed and subsequently edited by Dr. SM.

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Correspondence to Smita Mohanty.

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Pattanayak, I., Alex, Y. & Mohanty, S. Advancing strategies towards the development of tissue engineering scaffolds: a review. J Mater Sci 58, 12847–12898 (2023). https://doi.org/10.1007/s10853-023-08798-5

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