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Fluoxetine, an Antidepressant Drug, Inhibited Cigarette Smoke-Induced Pulmonary Inflammation and Apoptosis in Rats

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Abstract

The present study was designed to evaluate the anti-inflammatory effect of fluoxetine (Flu) against cigarette smoke (CS)-induced chronic obstructive pulmonary disease (COPD) in rats. Forty male Sprague-Dawley (SD) rats were randomly assigned to five groups: control group, CS group, dexamethasone (2 mg/kg) group, and flu (2 mg/kg). H&E staining demonstrated that Flu inhibited CS-induced pathological injury. In addition, Flu could restore the levels of superoxide dismutase (SOD) and malondialdehyde (MDA) in serum. Flu also inhibited the levels of cytokines including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β). Furthermore, flu significantly inhibited the protein levels of TLR/NF-κB and apoptosis pathway in CS-induced rats. Our findings suggested that flu might effectively ameliorate the progression of COPD via inflammation and apoptosis pathway in rats.

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Author notes

  1. Zhiyong Cai and Jindi Liu are contributed equally to this work.

Authors and Affiliations

  1. Newborn department, Yancheng Maternity and Child Health Care Hospital, Yancheng, Jiangsu Province, 224000, China

    Zhiyong Cai, Hongliang Bian, Jinlan Cai, Qing Jin & Jijing Han

  2. Nursing department, Yancheng Maternity and Child Health Care Hospital, Yancheng, Jiangsu Province, 224000, China

    Jindi Liu

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  1. Zhiyong Cai
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  2. Jindi Liu
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  4. Jinlan Cai
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  5. Qing Jin
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Correspondence to Hongliang Bian.

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Cai, Z., Liu, J., Bian, H. et al. Fluoxetine, an Antidepressant Drug, Inhibited Cigarette Smoke-Induced Pulmonary Inflammation and Apoptosis in Rats. Inflammation 40, 1375–1381 (2017). https://doi.org/10.1007/s10753-017-0580-y

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  • DOI: https://doi.org/10.1007/s10753-017-0580-y

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