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Correlation of ventricle epicardial fat volume and triglyceride-glucose index in patients with chronic heart failure

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Abstract

To explore the association of ventricle epicardial fat volume (EFV) calculated by cardiac magnetic resonance (CMR) and the insulin resistance indicator of triglyceride–glucose (TyG) index in patients with chronic HF (CHF), this retrospective cohort study included adult CHF patients with confirmed diagnosis of heart failure from January 2018 to December 2020. All patients underwent 3.0T CMR, and EFV were measured under short-axis cine. Spearman correlation, multivariate linear regression, and restricted cubic spline (RCS) regression were used to analyze their association. There were 516 patients with CHF, of whom 69.8% were male. Median EFV was 57.14mL and mean TyG index was 8.48. Spearman correlation analysis showed that TyG index was significantly correlated with the EFV in CHF patients (r = 0.247, P < 0.001). Further analysis showed that TyG index levels were significantly associated with EFV as both continuous variables (Unstandardized β = 6.556, P < 0.001) and across the increasing quartiles (β = 7.50, 95% CI [1.41, 13.59], P < 0.05). RCS demonstrated there were a positive trend and linear association between EFV and TyG index in CHF patients (P for nonliearity = 0.941). In patients with CHF, the TyG index was positively and linearly associated with the EFV, which supports the metabolic roles of epicardial adipose tissue regarding insulin resistance.

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All data generated or analyzed during this study are included in this article. The data that support the findings of this study are available from the corresponding author, X.L., upon reasonable request.

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Funding

This work was supported by Key Program of National Natural Science Foundation of China (81730106 to XL Li), General Program of National Natural Science Foundation of China (82370389, 81970339 to XL Li, 82270394 to HF Zhang), The National High Technology Research and Development Program of China (2017YFC1700505 to XL Li), and project from Gusu School (GSRCKY20210204 to HF Zhang). Dr. XL Li and HF Zhang are Associate Fellows at the Collaborative Innovation Center for Cardiovascular Disease Translational Medicine.

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  1. Iokfai Cheang and Xu Zhu contributed equally to this work.

Authors and Affiliations

  1. National Key Laboratory for Innovation and Transformation of Luobing Theory, Department of Cardiology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China

    Iokfai Cheang, Xu Zhu, Xinyi Lu, Shi Shi, Xin Yue, Yuan Tang, Shengen Liao, Wenming Yao, Yanli Zhou, Haifeng Zhang & Xinli Li

  2. Department of Radiology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China

    Yujie Gao, Yinsu Zhu & Yi Xu

  3. Department of Cardiology, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, 215002, China

    Haifeng Zhang

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Contributions

Conceptualization, Iokfai Cheang and Xinli Li; Data curation, Xin Yue, Yuan Tang and Yujie Gao; Formal analysis, Iokfai Cheang; Funding acquisition, Xinli Li; Investigation, Iokfai Cheang, Xu Zhu, Xinyi Lu and Shi Shi; Methodology, Xu Zhu; Project administration, Yinsu Zhu, Yi Xu and Xinli Li; Resources, Yinsu Zhu and Yi Xu; Software, Xu Zhu and Xinyi Lu; Supervision, Shengen Liao and Wenming Yao; Validation, Shi Shi, Yanli Zhou and Haifeng Zhang; Visualization, Xin Yue, Yuan Tang and Yujie Gao; Writing – original draft, Iokfai Cheang; Writing – review & editing, Iokfai Cheang, Xu Zhu and Xinli Li. All authors have reviewed and agreed to the published version of the manuscript.

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Correspondence to Yi Xu or Xinli Li.

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This study protocol was reviewed and approved by the independent institutional ethical committee of the First Affiliated Hospital of Nanjing Medical University (Approval No. 2022-SR-052), and conducted in accordance with the Declaration of Helsinki. Written informed consent was obtained from patients to participate in the study.

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Cheang, I., Zhu, X., Lu, X. et al. Correlation of ventricle epicardial fat volume and triglyceride-glucose index in patients with chronic heart failure. Int J Cardiovasc Imaging 40, 789–799 (2024). https://doi.org/10.1007/s10554-024-03048-4

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